Amelioration of estrogen deficiency-induced obesity by collagen hydrolysate

Abstract

Objectives: Menopausal transition with declining estrogen levels significantly affects the physiological properties of women and consequently contributes to a series of medical conditions, including obesity. Obesity is a crucial risk factor associated with cardiovascular diseases, diabetes mellitus, and breast cancer. Increasing dietary protein content improves satiety and energy expenditure. Thus, we hypothesize that supplementing with collagen, a common dietary protein, may alleviate menopause-induced obesity.Methods: We used ovariectomized (OVX) rats to mimic a menopausal human. The body weight of OVX rats significantly increased compared with that of sham-operated rats (P<0.05), but uterus weight was decreased. Adipocyte size in perigonadal adipose tissue also increased (P<0.05).Results: By contrast, OVX rats supplemented with aqueous collagen hydrolysate (2.5 mg/mL) exhibited significant attenuation in body weight gain and adipocyte enlargement (P<0.05), but insignificant change in uterus weight. Further investigation indicated that collagen hydrolysate supplementation insignificantly affected the levels of dorsal fat, serum total cholesterol, and serum triacylglycerol. Levels of serum biochemical factors, calcium, phosphorus, and glucose were also insignificantly altered by collagen hydrolysate supplementation.Conclusion: Collagen hydrolysate supplementation reduced body weight gain and adipocyte enlargement in response to ovariectomy but slightly affected blood lipids, calcium, and glucose in both sham-operated and OVX rats. Collagen hydrolysate supplementation is beneficial in ameliorating estrogen deficiency-induced obesity and its associated risk factors.

Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial

“…Although there is currently limited knowledge on the effects of collagen peptides on FM, preclinical trials have confirmed that a supplementation with collagen peptides reduces adipocyte size [57].…”

The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review

“…Previous studies have also observed an increase in ECM synthesis in connective tissue with COL supplementation (Schunck and Oesser 2013). For changes in FM, COL has shown to reduce body weight gain and adipocyte enlargement (Chiang et al 2016). However, the BF losses reported in elderly sarcopenic men was likely to be higher, as participants had ~ 30% BF (Zdzieblik et al 2015), whereas participants in Kirmse et al (2019) had ~ 11% BF at baseline.…”

Animal, Plant, Collagen and Blended Dietary Proteins: Effects on Musculoskeletal Outcomes

“…Collagen proteins are the most abundant proteins in the human body [121], accounting for 25-30% of total protein body mass [26], and are the major constituents of many tissues, including connective tissue, tendons, ligaments and bones [122]. Thus, dietary collagen is likely a key mediator of musculoskeletal remodelling throughout the lifespan.…”

“…More recently, Jendricke et al [135] also reported greater increases in fat-free mass and a greater decrease in fat mass following dietary collagen supplementation, supporting positive body composition changes in response to this form of supplement. In the absence of known mechanisms, it has been suggested that a reduction in adipocyte size may contribute to changes in fat mass [121], in addition to the already mentioned hypothesis of ECM adaptations contributing to fat-free mass gains. That said, collagen peptide supplementation in older females did not increase rates of integrated collagen (or myofibrillar) MPS above baseline or in response to two bouts of RE [27], contradicting the suggestion of impacts on ECM remodelling (at least in older females).…”