2006
DOI: 10.1007/s00066-006-1587-8
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Amelioration of Early Radiation Effects in Oral Mucosa (Mouse) by Intravenous or Subcutaneous Administration of Amifostine

Abstract: Amifostine during daily fractionated irradiation is effective only if administered in the initial treatment phase, i.e., week 1 in the mouse. The differences in the effect in weeks 1 and 2 suggest mechanisms of action other than radical scavenging.

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Cited by 16 publications
(10 citation statements)
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“…Skin is the most commonly affected organ in radiation recall reactions [9,11,13]. Whereas radiation-induced lung reactions have been examined in detail [5,8], the pathophysiological mechanism of radiation recall itself is unknown. Prior tissue injury presumably plays a role, which can lead to changes in epithelial stem cells with altered expression and activity of various proteins [9,12].…”
Section: Discussionmentioning
confidence: 99%
“…Skin is the most commonly affected organ in radiation recall reactions [9,11,13]. Whereas radiation-induced lung reactions have been examined in detail [5,8], the pathophysiological mechanism of radiation recall itself is unknown. Prior tissue injury presumably plays a role, which can lead to changes in epithelial stem cells with altered expression and activity of various proteins [9,12].…”
Section: Discussionmentioning
confidence: 99%
“…increases in Gramnegative bacteria, particularly Enterobacteriaceae). 6 This mucositis, akin to that of the bowel, is difficult to manage specifically. Benzydamine hydrochloride mouth rinse or spray may provide symptomatic relief, but effective analgesia often requires opioids.…”
Section: Oral Ulcers Of Traumatic (Physical and Chemical) Etiologymentioning
confidence: 99%
“…No medication is approved for the prevention of oral mucositis associated with radiotherapy. Experimental therapies have been investigated, including epidermal growth factor (Sonis et al, 1992;Ryu et al, 2010), keratinocyte growth factor (KGF) (Dorr et al, 2005a,b;Kilic et al, 2007), amifostine (Cassatt et al, 2002;Cassatt et al, 2003;Fleischer and Dörr, 2006), and so on. Of these therapies, palifermin, a recombinant human KGF (rhKGF), demonstrates constant preventive effects in models of irradiation-induced oral mucositis.…”
Section: Introductionmentioning
confidence: 99%