Amelioration of diethylnitrosamine (DEN) induced renal oxidative stress and inflammation by Carissa carandas embedded silver nanoparticles in rodents

Singh, Deepika; Chaudhary, Deepak; Kumar, Vikas; Verma, Amita

doi:10.1016/j.toxrep.2021.03.014

Cited by 15 publications

(13 citation statements)

References 49 publications

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“…Moreover, DEN/AAF/CCl 4 administration also decreased other antioxidant enzyme activities such as GST and GR. These results were strongly supported by previous studies which reported that DEN induction increased the level of MDA and reduced the kidney GSH content and the antioxidant enzymes such as SOD, GPx, GR, and GST [ 77 , 78 ]. In contrast, STE, Sm, and Sb treatment significantly attenuated the elevated MDA level demonstrating that these treatments are effective in quenching free radicals.…”

Section: Discussionsupporting

confidence: 87%

Tackling of Renal Carcinogenesis in Wistar Rats by Silybum marianum Total Extract, Silymarin, and Silibinin via Modulation of Oxidative Stress, Apoptosis, Nrf2, PPARγ, NF-κB, and PI3K/Akt Signaling Pathways

Yassin

AbouZid

El-Kalaawy

et al. 2021

Oxidative Medicine and Cellular Longevity

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The present work was designed to assess the efficacy of Silybum marianum total extract (STE), silymarin (Sm), and silibinin (Sb) against experimentally induced renal carcinogenesis in male Wistar rats and their roles in regulating oxidative stress, inflammation, apoptosis, and carcinogenesis. The diethylnitrosamine (DEN)/2-acetylaminofluorene (AAF)/carbon tetrachloride (CCl4)-administered rats were orally treated with STE (200 mg/kg b.w.), Sm (150 mg/kg b.w.), and Sb (5 mg/kg b.w.) every other day either from the 1st week or from the 16th week of carcinogen administration to the end of 25th week. The treatments with STE, Sm, and Sb attenuated markers of toxicity in serum, decreased kidney lipid peroxidation (LPO), and significantly reinforced the renal antioxidant armory. The biochemical results were further confirmed by the histopathological alterations. The treatments also led to suppression of proinflammatory mediators such as NF-κβ, p65, Iκβα, and IL-6 in association with inhibition of the PI3K/Akt pathway. Furthermore, they activated the expressions of PPARs, Nrf2, and IL-4 in addition to downregulation of apoptotic proteins p53 and caspase-3 and upregulation of antiapoptotic mediator Bcl-2. The obtained data supply potent proof for the efficacy of STE, Sm, and Sb to counteract renal carcinogenesis via alteration of varied molecular pathways.

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Section: Discussionsupporting

confidence: 87%

Tackling of Renal Carcinogenesis in Wistar Rats by Silybum marianum Total Extract, Silymarin, and Silibinin via Modulation of Oxidative Stress, Apoptosis, Nrf2, PPARγ, NF-κB, and PI3K/Akt Signaling Pathways

Yassin

AbouZid

El-Kalaawy

et al. 2021

Oxidative Medicine and Cellular Longevity

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“… 8 The use of toxic chemicals in their chemical synthesis is a major concern as they show adverse effects on the environment as well as on living beings. 9 , 10 Recently, remarkable attention has been paid to the synthesis of AgNPs via a greener route. Keeping in mind the need for sustainable nanomaterial synthesis, a lot of novel routes have been optimized based on the bioinspired reduction 11 − 13 and, in general, termed biological methods.…”

Section: Introductionmentioning

confidence: 99%

Green Route Synthesis and Characterization Techniques of Silver Nanoparticles and Their Biological Adeptness

et al. 2022

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The development of the most reliable and green techniques for nanoparticle synthesis is an emerging step in the area of green nanotechnology. Many conventional approaches used for nanoparticle (NP) synthesis are expensive, deadly, and nonenvironmental. In this new era of nanotechnology, to overcome such concerns, natural sources which work as capping and reducing agents, including bacteria, fungi, biopolymers, and plants, are suitable candidates for synthesizing AgNPs. The surface morphology and applications of AgNPs are significantly pretentious to the experimental conditions by which they are synthesized. Available scattered information on the synthesis of AgNPs comprises the influence of altered constraints and characterization methods such as FTIR, UV–vis, DLS, SEM, TEM, XRD, EDX, etc. and their properties and applications. This review focuses on all the above-mentioned natural sources that have been used for AgNP synthesis recently. The green routes to synthesize AgNPs have established effective applications in various areas, including biosensors, magnetic resonance imaging (MRI), cancer treatment, surface-enhanced Raman spectroscopy (SERS), antimicrobial agents, drug delivery, gene therapy, DNA analysis, etc. The existing boundaries and prospects for metal nanoparticle synthesis by the green route are also discussed herein.

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“…DEN (200 mg/kg) was injected intraperitoneally to induce kidney cancer in this study 2,11) . DEN (200 mg/kg) was dissolved in phosphate buffer saline (PBS) at pH＝4.5 for a few minutes 1) .…”

Section: Preparation Of Toxicantmentioning

confidence: 99%

“…Renal tumor markers such as thymidine ［3H］ incorporation and ODC were determined using a modified version of a previously published method 11,23,24) .…”

Section: Renal Tumormentioning

confidence: 99%

“…DEN induces the cellular injury and oxidative stress due to involvement of free radicals and it induces the mutagenicity, carcinogenicity and cytotoxicity 4,5) . During the DEN induce organ toxicity, huge number of free radicals generated and start the induction of tissue toxicity via suppression the antioxidant defence system 3,11) . According to prior studies, free radicals and associated lipid peroxides have a role in the pathogenesis of age-related chronic degenerative disease and exogenous oxidative stress 8) .…”

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confidence: 99%

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<i>Pueraria montana</i> (Kudzu vine) Ameliorate the Inflammation and Oxidative Stress against Fe-NTA Induced Renal Cancer

et al. 2022

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IntroductionRenal cancer is having 3 rd rank among all types of cancer and approximately 1,30,000 men cases and 63,000 deaths found from this cancer every year 1) . The kidney is more susceptible to the toxicant due to 2 main reasons such as high volume of blood flowing via it and filter the huge volume of toxins which can deposit in the kidney tubules 2,3) . Due to this systemic toxicity occurred: suppressed the capability to evacuate body wastes, inability to balance the electrolyte and body fluid and reduced the synthesis of essential hormones 4) . Various medicine and toxic chemical can induce the renal injury, are recognized as the toxico-# Both equally contributed

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Amelioration of diethylnitrosamine (DEN) induced renal oxidative stress and inflammation by Carissa carandas embedded silver nanoparticles in rodents

Abstract: Graphical abstract

Cited by 15 publications

References 49 publications

Tackling of Renal Carcinogenesis in Wistar Rats by Silybum marianum Total Extract, Silymarin, and Silibinin via Modulation of Oxidative Stress, Apoptosis, Nrf2, PPARγ, NF-κB, and PI3K/Akt Signaling Pathways

Tackling of Renal Carcinogenesis in Wistar Rats by Silybum marianum Total Extract, Silymarin, and Silibinin via Modulation of Oxidative Stress, Apoptosis, Nrf2, PPARγ, NF-κB, and PI3K/Akt Signaling Pathways

Green Route Synthesis and Characterization Techniques of Silver Nanoparticles and Their Biological Adeptness

<i>Pueraria montana</i> (Kudzu vine) Ameliorate the Inflammation and Oxidative Stress against Fe-NTA Induced Renal Cancer

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