Amelioration of Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats by Acacia catechu Leaves Extract

Abstract

Objective The present study was performed to evaluate the ethanolic extract of leaves of Acacia catechu (A. catechu) for its effect on streptozotocin (STZ)-induced diabetes mellitus (DM) and its renal complications in male Wistar albino rats. Materials and Methods Male Wistar albino rats were grouped into control (A), STZ-induced DM (B), STZ-induced DM rats with A. catechu orally of 75 mg/kg body weight (kbw) for 35 days (C), with each group having six rats (n = 6) weighing between 200 to 250 g each. Group A receives only water, orally; group B receives a single dose of STZ at 45 mg/kbw intraperitoneal administration (IP); group C receives STZ IP and oral A. catechu for 35 days. On the 36th day, animals were euthanized, the kidney tissues were analyzed for biochemical parameters, such as GOT (glutamic oxaloacetic transaminase), GPT (glutamic pyruvic transaminase), oxidative stress assessment parameters, and histopathological studies. Results In group C rats, activities of the enzymes were nearer to group A when compared with group B. Histopathological findings were also suggesting that renal toxicity were observed at a lesser extent in group C. Conclusion The ethanolic extract of A. catechu signified as nephroprotective effect. The present data could provide adequate confirmation of the efficacy of ethanolic extract of leaves of A. catechu for further experimental studies on a standardized formulation.

Magnesium Enhances the Hepatorenal Protective Effects of <i>Lippia multiflora</i> Aqueous Leaves Extract in Streptozotocin-Diabetic Rats

“…The induction of diabetes caused an increase in serum levels of AST, ALT, urea and creatinine in animals as revealed by numerous works [3] [4] [11] [16]. In general, an increase in transaminases (AST and ALT) in the blood implies liver It therefore emerges from these observations that magnesium interacts positively with the secondary metabolites contained in Lippia multiflora aqueous leaves extract.…”

“…In general, an increase in transaminases (AST and ALT) in the blood implies liver It therefore emerges from these observations that magnesium interacts positively with the secondary metabolites contained in Lippia multiflora aqueous leaves extract. These could include flavoids, alkaloids, tannins highlighted by various studies [2] [38] and whose hepatoprotective and nephroprotective actions have been demonstrated [16] [33] [39].…”

Effects of Various Herbal leaves Extract and Their Phytoconstituents in the Cure of Diabetic Nephropathy by ‘Streptozotocin-induced in Rats’ Model - A Review

“…Acacia catechu leaves ameliorate Streptozotocininduced diabetic rats' nephropathy Moderate-tosevere degenerative characteristics, such as dilated tubules, degraded tubules, glomerular congestion, interstitial inflammatory infiltration, and atrophy of the glomerulus seen with dilated glomerular space, were visible in the extract and observation 82 .…”

Anti-diabetic Potential of Indigenous Medicinal Plants of Cholistan Desert, Pakistan: A Review

“…Abroma augusta (locally known as Ult kambal) leaf extract shows hypoglycemic effect on alloxan induced diabetic rats [ 29 ]. Acacia arabica (Fabeceae) bark exhibits antihyperglycemic effect in streptozotocin-induced diabetic rats [ 30 ].…”