Amelioration of Cisplatin-Induced Nephrotoxicity in Rats by Curcumin and α-Tocopherol

Palipoch, Sarawoot; Punsawad, Chuchard; Chinnapun, Dutsadee; Suwannalert, Prasit

doi:10.4314/tjpr.v12i6.16

Cited by 21 publications

(11 citation statements)

References 20 publications

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“…In this study, curcumin attenuated the etoposideinduced MDA formation and the decreased testicular GSH as well as SOD and CATA activities, possibly due to its intrinsic antioxidant properties (Palipoch et al, 2013). Similarly, curcumin protected against testicular oxidative damage induced by di-nbutylphthalate due to its intrinsic antioxidant properties (Farombi et al, 2007).…”

Section: Discussionsupporting

confidence: 50%

Pretreatment with montelukast and curcumin protect against etoposide-induced testicular toxicity in rats: role of oxidation, inflammation and apoptosis

Essawy

Abdelfatah²,

Abo-Elmatty

2018

Records of Pharmaceutical and Biomedical Sciences

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The success of etoposide for the treatment of testicular cancer is limited by its undesirable side effects on reproductive system, which is generally ascribed to inflammation and oxidative stress. In the current study, the protective effects of montelukast and curcumin on etoposide-induced reproductive toxicity were investigated. Rats were divided into six groups; group 1 was kept as control. In groups 2, 3; montelukast and curcumin were administered at doses of (10 mg/kg/day) and (200 mg/Kg/day) respectively for 10 days. In group 4, etoposide was intraperitoneally administered at a single dose of 10 mg/kg, while in groups 5 and 6; etoposide and montelukast or curcumin, respectively, were given together at the same doses. Etoposide induced oxidative stress via significant increase in MDA level and significant decrease in GSH level as well as SOD and CATA activities. Montelukast and curcumin prevented these effects through antioxidant properties. In addition, the deleterious effects of etoposide on spermatogenesis, serum testosterone level, oxidative stress, ATP, mtDNA and nDNA damage as well as histopathological changes are eliminated by montelukast or curcumin treatment, notably curcumin could normalized some of these parameters. The present study showed that montelukast and curcumin can reverse toxic effects of etoposide on the reproductive system that can be contributed due to anti-oxidant, antiinflammatory and antiapoptotic potential.

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Section: Discussionsupporting

confidence: 50%

Pretreatment with montelukast and curcumin protect against etoposide-induced testicular toxicity in rats: role of oxidation, inflammation and apoptosis

Essawy

Abdelfatah²,

Abo-Elmatty

2018

Records of Pharmaceutical and Biomedical Sciences

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“…route for 24 h prior a single dose injection of cisplatin (20 mg/kg b.w.) [ 16 ]. Following 72 h of first injection, rats were anesthetized with thiopental sodium intraperitoneally (50 mg/kg b.w.).…”

Section: Methodsmentioning

confidence: 99%

Hepatoprotective effect of curcumin and alpha-tocopherol against cisplatin-induced oxidative stress

Palipoch

Punsawad

Koomhin

et al. 2014

BMC Complement Altern Med

112

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Backgroundcis-Diammineplatinum (II) dichloride (cisplatin) is the important anti-cancer agent useful in treatment of various cancers. Unfortunately, it can produce unwanted side effects in various tissues, including the liver. The present study investigated the possible protective role of curcumin and α-tocopherol against oxidative stress-induced hepatotoxicity in rats upon cisplatin treatment.MethodsMale Wistar rats were divided into five groups (n = 5). Saline and Cis groups, rats were intraperitoneal (i.p.) injected with normal saline and cisplatin [20 mg/kg body weight (b.w.)], respectively. Cis + α-tocopherol group, Cis + Cur group and Cis + α-tocopherol + Cur group, rats were pre-treated with a single dose of α-tocopherol (250 mg/kg b.w.), curcumin (200 mg/kg b.w.) and combined α-tocopherol with curcumin, respectively, for 24 h prior the administration of cisplatin. After 72 h of first injection, specimens were collected. Liver enzyme, lipid peroxidation biomarker, liver histopathology and gene expression of liver nicotinamide adenine dinucleotide phosphate (NADPH) oxidase were investigated.ResultsCisplatin revealed a significant increase of hepatic malondialdehyde (MDA) levels and a significant reduction of hepatic superoxide dismutase (SOD) and catalase activities compared to the saline group. It elicited a marked increase of the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and demonstrated the liver pathologies including liver congestion, disorganization of hepatic cords and ground glass appearance of hepatocytes. It also demonstrated a significant increase of NADPH oxidase gene expression compared to saline group. Pre-treatment with combined curcumin and α-tocopherol improved the liver enzymes, lipid peroxidation biomarker, liver histopathology and gene expression of liver NADPH oxidase in cisplatin-treated rats.ConclusionsThe findings indicate that pre-treatment with combined curcumin and α-tocopherol can protect cisplatin-induced hepatotoxicity including the biochemical, histological and molecular aspects. The down-regulations of NADPH oxidase gene expression may be involved in abrogating oxidative stress via reduction of reactive oxygen species (ROS) production.

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“…(Jobin et al, 1999; Kuhad et al, 2007; Ueki et al, 2013). The combination of CUR and α-tocopherol is renoprotective by inhibiting of NADPH oxidase (Palipoch et al, 2013). Former studies have urged that usage of rosiglitazone and CUR (anti-inflammatory agents) is safe and one of the key approaches to attenuate CIS-induced renotoxicity (Ueki et al, 2013; Kumar et al, 2013c).…”

Section: Introductionmentioning

confidence: 99%

Curcumin Ameliorates Cisplatin-Induced Nephrotoxicity and Potentiates Its Anticancer Activity in SD Rats: Potential Role of Curcumin in Breast Cancer Chemotherapy

Kumar

Barua²,

Sulakhiya

et al. 2017

Front. Pharmacol.

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Breast malignant neoplastic disease is one of the most complex diseases, as it is a multifactorial disease in which virtually all the targets are instantly or indirectly inter-reliant on each other. Cisplatin (CIS), an inorganic antineoplastic agent is widely utilized in the treatment of various solid tumors including breast cancer. Despite everything, its clinical use is limited, due to ototoxicity, peripheral neuropathy, and nephrotoxicity. The present work was directed to assess the combined result of curcumin (CUR) and CIS in 7, 12-dimethyl benz[a]anthracene (DMBA) induced breast cancer in rats and the prevention of nephrotoxicity induced by the latter. CIS-induced nephrotoxicity was assessed by change in body weight, kidney weight, altered levels of BUN, creatinine, TNF-α, IL-6, IL-8, IL-10, and histopathology of the kidney. Anticancer activity was assessed by measurement of tumor weight, tumor volume, % tumor inhibition, levels of PPAR-γ, and BDNF in mammary tumors and histopathology of mammary tumors. CUR pre-treatment mitigated nephrotoxicity by reducing the inflammatory markers (TNF-α, IL-6, and IL-8; p < 0.001). Further, it reduced mammary cancer via increasing the expression of PPAR-γ (p < 0.001) and decreasing the expression of BDNF (p < 0.001) in mammary tumors. It also reduced tumor volume, further postulating that CUR might adjunct the anticancer activity of the CIS. To the best of our knowledge, this is the first report, which showed that CUR ameliorated CIS-induced nephrotoxicity and improved its anticancer activity in DMBA induced breast cancer in female Sprague-Dawley rats.

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Amelioration of Cisplatin-Induced Nephrotoxicity in Rats by Curcumin and α-Tocopherol

Cited by 21 publications

References 20 publications

Pretreatment with montelukast and curcumin protect against etoposide-induced testicular toxicity in rats: role of oxidation, inflammation and apoptosis

Pretreatment with montelukast and curcumin protect against etoposide-induced testicular toxicity in rats: role of oxidation, inflammation and apoptosis

Hepatoprotective effect of curcumin and alpha-tocopherol against cisplatin-induced oxidative stress

Curcumin Ameliorates Cisplatin-Induced Nephrotoxicity and Potentiates Its Anticancer Activity in SD Rats: Potential Role of Curcumin in Breast Cancer Chemotherapy

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