Amelioration of Bleomycin and Methotrexate-Induced Pulmonary Toxicity by Serratiopeptidase and Fisetin

Shahbaz, Muhammad; Kamran, Sairah Hafeez; Anwar, Rukhsana

doi:10.1080/01635581.2020.1860242

Cited by 10 publications

(5 citation statements)

References 32 publications

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“…However, to date, there has been no proven efficacy in preventing bleomycin‐induced lung injury in humans. Many nonclinical studies have reported that N‐acetylcysteine amide, a thiol antioxidant, can prevent and ameliorate bleomycin‐induced toxicity in human alveolar basal epithelial cells, 8,9 therefore N‐acetylcysteine amide was administered via inhalation and intravenous routes. In addition, corticosteroids are widely considered to be the standard therapy in symptomatic patients with bleomycin‐induced lung injury 10 .…”

Section: Discussionmentioning

confidence: 99%

Bleomycin overdose in a patient with stage II Hodgkin lymphoma: A case report of a medication error

Jieting

Xue

Chen

et al. 2023

Brit J Clinical Pharma

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Bleomycin is an antibiotic with cytotoxic properties that is commonly used in combination regimens for the treatment of Hodgkin lymphoma. The inconsistency in the dosage nomenclature of bleomycin appears universally, which increases the risk of medication errors. However, to the best of our knowledge, no such cases have been reported. Herein, we present a rare case report of a medication error caused by a bleomycin overdose. At the third cycle of chemotherapy, a 25‐year‐old patient with stage II Hodgkin lymphoma received a 10 times higher dose of bleomycin (150 USP) than that usually used as part of the doxorubicin, bleomycin, vindesine and dacarbazine protocol (ABVD). After the medication error was discovered, the patient was immediately treated with intravenous rehydration and furosemide to promote drug clearance. Additionally, methylprednisone and acetylcysteine were administered to prevent lung injury. However, the patient developed slight nausea and mild rash, which gradually improved after treatment. After evaluation with positron emission spectrometry‐computed tomography (PET‐CT), the patient received four cycles of AVD chemotherapy. No other obvious abnormalities were observed during the treatment and 1‐year follow‐up period. Hence, the toxicities, clinical management and selection of further chemotherapy after bleomycin overdose in such cases deserved serious attention. More importantly, management measures after this error may be used as a reference in other hospitals.

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Section: Discussionmentioning

confidence: 99%

Bleomycin overdose in a patient with stage II Hodgkin lymphoma: A case report of a medication error

Jieting

Xue

Chen

et al. 2023

Brit J Clinical Pharma

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“…Oxidative stress has been implicated as an important factor in the development of bleomycin-induced pulmonary toxicity. A lot of non-clinical studies have reported that N-acetylcysteine amide, a thiol antioxidant, could prevent and ameliorate bleomycin-induced toxicity in human alveolar basal epithelial cells (8,9). Therefore, the N-acetylcysteine amid was administered via inhalation and intravenous route.…”

Section: Discussionmentioning

confidence: 99%

Bleomycin Overdose in a Patient with Stage II Hodgkin Lymphoma: A Case Report of a Medication Error

Jieting¹,

Xue²,

Chen³

et al. 2022

Preprint

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Bleomycin is an antibiotic with cytotoxic properties, commonly used in combination regimens for the treatment of Hodgkin lymphoma. The inconsistency in dosage nomenclature of bleomycin seems to be universal in many countries, which increases the risk of medication error. However, as far as we know no cases have reported. Here we present a case report of a medication error caused by bleomycin overdose. A 25-year-old patient with Stage II Hodgkin Lymphoma received a 150 USP bleomycin, which dosage was ten times higher than usually used, as part of the doxorubicin, bleomycin, vindesine, dacarbazine protocol (ABVD) at the third cycles of chemotherapy. After the medication error was found, the patient was immediately treated with intravenous rehydration and furosemide to promote clearance of drugs. To prevent lung injury, the methylprednisone and acetylcysteine was given. The patient developed a slight nausea and a mild rash, which gradually improved after the treatment. After the evaluation with PET-CT, the patient received four cycles of AVD chemotherapy. During the treatment and one-year follow-up period, no other obvious abnormalities were observed. The toxicities, clinical managements and selection of further chemotherapy after bleomycin overdose deserved serious attention in this case. More importantly, the management measures after this error can be used for reference in other hospitals.

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“…Responses were evaluated after five minutes of anesthesia to confirm the anesthetic stage. Following the confirmation of anesthesia, rats were euthanized using cardiac puncture, and blood and tissues were subsequently collected for further analysis [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

Modulatory effects of rutin and vitamin A on hyperglycemia induced glycation, oxidative stress and inflammation in high-fat-fructose diet animal model

Iqbal,

Hafeez Kamran,

Siddique

et al. 2024

PLoS ONE

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In the current study we investigated the impact of combination of rutin and vitamin A on glycated products, the glyoxalase system, oxidative markers, and inflammation in animals fed a high-fat high-fructose (HFFD) diet. Thirty rats were randomly divided into six groups (n = 5). The treatments, metformin (120 mg/kg), rutin (100 mg/kg), vitamin A (43 IU/kg), and a combination of rutin (100 mg/kg) and vitamin A (43 IU/kg) were given to relevant groups of rats along with high-fructose high-fat diet for 42 days. HbA1c, D-lactate, Glyoxylase-1, Hexokinase 2, malondialdehyde (MDA), glutathione peroxidase (GPx), catalase (CAT), nuclear transcription factor-B (NF-κB), interleukin-6 (IL-6), interleukin-8 (IL-8) and histological examinations were performed after 42 days. The docking simulations were conducted using Auto Dock package. The combined effects of rutin and vitamin A in treated rats significantly (p < 0.001) reduced HbA1c, hexokinase 2, and D-lactate levels while preventing cellular damage. The combination dramatically (p < 0.001) decreased MDA, CAT, and GPx in treated rats and decreased the expression of inflammatory cytokines such as IL-6 andIL-8, as well as the transcription factor NF-κB. The molecular docking investigations revealed that rutin had a strong affinity for several important biomolecules, including as NF-κB, Catalase, MDA, IL-6, hexokinase 2, and GPx. The results propose beneficial impact of rutin and vitamin A as a convincing treatment strategy to treat AGE-related disorders, such as diabetes, autism, alzheimer’s, atherosclerosis.

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Amelioration of Bleomycin and Methotrexate-Induced Pulmonary Toxicity by Serratiopeptidase and Fisetin

Cited by 10 publications

References 32 publications

Bleomycin overdose in a patient with stage II Hodgkin lymphoma: A case report of a medication error

Bleomycin overdose in a patient with stage II Hodgkin lymphoma: A case report of a medication error

Bleomycin Overdose in a Patient with Stage II Hodgkin Lymphoma: A Case Report of a Medication Error

Modulatory effects of rutin and vitamin A on hyperglycemia induced glycation, oxidative stress and inflammation in high-fat-fructose diet animal model

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