Amelioration by chicory seed extract of diabetes- and oleic acid-induced non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) via modulation of PPARα and SREBP-1

Ziamajidi, Nasrin; Khaghani, Shahnaz; Hassanzadeh, Gholamreza; Vardasbi, Safoura; Ahmadian, Shahram; Nowrouzi, Azin; Ghaffari, Seyed Mahmood; Abdirad, Afshin

doi:10.1016/j.fct.2013.04.018

Cited by 115 publications

(79 citation statements)

References 70 publications

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“…Non-Alcoholic Fatty Liver Disease is classified into simple steatosis and Non-Alcoholic Steatohepatitis (NASH). Simple steatosis is a benign condition that can be reversed by some drugs, whereas NASH is an irreversible form of the disease, in which not only steatosis but also hepatocellular inflammation injury are present and can often cause progress to fibrosis, cirrhosis and Hepatocellular Carcinoma (HCC) (6). Herbal medicines derived from plant extracts due to their low cost, availability, and fewer side effects, are increasingly being used for treatment of a wide variety of clinical diseases (7,8).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Effect of Silybum marianum Plant Extract on Tamoxifen-Induced Fatty Liver in Rats

Behrouj¹,

Ziamajidi²,

Abbasalipourkabir³

et al. 2015

Avicenna J Med Biochem

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Background: Tamoxifen (TMX) is a synthetic drug that is widely used for treatment of breast cancer. Despite the beneficial effects of TMX, the use of this drug has several side effects such as the development of Non-Alcoholic Fatty Liver Disease (NAFLD) in the patients. Silybum marianum is the most researched plant in treatment of liver disease. Objectives: In this study the effect of Silybum marianum Extract (SME) on histological and biochemical parameters in TMX-treated rats was investigated. Materials and Methods: Adult female Wistar rats were divided to four groups; 1) normal control untreated rats, 2) SME-treated rats, that received only SME in a dose of 1.6 g/kg body weight/day, oral gavage for 14 days, 3) TMX-treated rats, that received TMX in a dose of 1 mg/ kg body weight/day, subcutaneously, for seven days, 4) TMX-SME-treated rats, that received TMX in a dose of 1 mg/kg body weight/day, subcutaneously, for seven days and then SME by oral gavage for 14 days. The groups were compared in terms of serum glucose, triglyceride, cholesterol, Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP), High-Density LipoproteinCholesterol (HDL-C), Low-Density Lipoprotein-Cholesterol (LDL-C), total protein and liver triglyceride amount, and histological findings. Results: Concentrations of HDL-C and protein decreased and activity of ALT increased in TMX group compared with the control group. The SME increased protein concentration and decreased ALT activity in TMX-SME group compared with the TMX group. Histopathological examination and triglyceride assay in liver tissues showed lipid accumulation in the TMX-treated rats and amelioration of lipid accumulation in the liver of TMX-SME-treated rats. Conclusions: Intake of water extract of Silybum marianum is a useful treatment for liver function in drug-induced fatty liver.

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Section: Introductionmentioning

confidence: 99%

Therapeutic Effect of Silybum marianum Plant Extract on Tamoxifen-Induced Fatty Liver in Rats

Behrouj¹,

Ziamajidi²,

Abbasalipourkabir³

et al. 2015

Avicenna J Med Biochem

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“…In non-simultaneous treatment, Cichorium intybus seed extract up-regulated the expression of both genes and restored the normal levels of the corresponding proteins; with a greater stimulating effect on PPARα, Cichorium intybus seed extract acted as a PPARα agonist. Cichorium intybus seed extract released glycerol from HepG2 cells, and targeted the first and the second hit phases of hepatic steatosis [42].…”

Section: Introductionmentioning

confidence: 99%

Detoxification capacity and protective effects of medicinal plants (part 2): plant based review

Al-Snafi¹

2016

IOSRPHR

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“…The components of chicory root are different from leaves and so their effects on diabetes treatment may be different. The effects of chicory whole plant, chicory seed (29) and chicory root on blood glucose and lipids have been reported previously (28)(29)(30). However, the effects of aqueous extract of chicory leaf on weight, blood glucose and lipids need to be examined.…”

Section: Introductionmentioning

confidence: 99%

“…The effects of ethanol extract of whole plant Cichorium intybus on diabetes was studied in STZ diabetic rats and were reported to reduce blood glucose, blood triglyceride and blood cholesterol (28). Ziamajidi et al also reported hepatic protective effects for chicory extract in hepatic steatosis in rats (in vivo), and in HepG2 cells (in vitro) (29). The components of chicory root are different from leaves and so their effects on diabetes treatment may be different.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Chicory Leaf Aqueous Extract on Body Weight, Serum Glucose and Lipid Levels in Streptozotocin Induced Diabetic Rats

et al. 2017

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A B S T R A C TBackground and Objectives: Diabetes mellitus is a common chronic disease worldwide. Although it is treated with a number of methods including diet therapy, hypoglycemic agents, insulin and some herbs, its' prevalence and complications are rapidly increasing. Chicory intybus has been used as a traditional diabetes treatment in Iran, Egypt, and other countries but there is a lack of convincing evidence on its effect. This study was designed to evaluate the effects of aqueous extract of chicory leaf on body weight, serum insulin, glucose and lipids in diabetic male Wistar rats. Materials and Methods:Forty male Wistar rats were divided into five groups. Four groups were given streptozotocin intraperitoneally to induce diabetes. Three of the diabetic groups received varying concentrations of chicory aqueous extract for three weeks (12, 25 and 50 mg /kg body weight). The forth diabetic group and the non-diabetic group received distilled water (diabetic and healthy control groups respectively). Fasting blood glucose, serum triglyceride (TG), total cholesterol (TC), LDL and HDL levels were measured after 3 weeks of treatment. Results:The results did not show any significant effects on fasting blood glucose (173.5±126, 154.5±100, 247.7±46, 170.7±150.8 mg/dL) and serum lipids; LDL(19.5±7.7, 26.4±6.7, 24.2±7.7,24.7±6.8 mg/dL), HDL(41±22.8, 41.2±12, 44.7±12.1, 40±4.6 mg/dL), TG (103.5±35, 80.4±53.8, 111±70, 94±8.9 mg/dL) and TC (76.2±27.3, 80.4±53.8, 77±18.4, 72.7±15 mg/dl) in Streptozotocin induced diabetic groups receiving 12, 25 and 50 mg/kg aqueous chicory extract and diabetic control groups respectively. Conclusions:Chicory leaf aqueous extract had no significant effects on serum glucose and lipids of streptozotocin-induced diabetic rats.Keywords: Diabetes, Chicory extracts, Blood glucose, Cholesterol, Triglyceride, Rat IntroductionDiabetes mellitus is a very common health problem of the world, in both developed and developing countries and is one of the leading causes of death worldwide (1) . It is estimated that the number of world diabetics will exceed to over 400 million by 2030 (2). Recent studies indicate that the prevalence of diabetes in Iran, and in other developed and developing countries is increasing (3-6). Diabetes results in severe complications including hyperlipidemia, neuropathy, nephropathy, retinopathy and cardiovascular disorders and therefore impose great economic costs to the families and countries (7,8). Diet therapy, exercise, pharmacotherapy and herbal medicines are strategies to treat diabetes mellitus. Herbs have been used for diabetes mellitus treatment in ancient Iran, China, Egypt and other countries (9, 10). Chicory intybus (Cichorium intybus L.), is a traditional herbal medicine, which belongs to the Asteraceae family with six species mostly in Europe and Asia (11) (29) and chicory root on blood glucose and lipids have been reported previously (28-30). However, the effects of aqueous extract of chicory leaf on weight, blood glucose and lipids need to be examined. This st...

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Amelioration by chicory seed extract of diabetes- and oleic acid-induced non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) via modulation of PPARα and SREBP-1

Cited by 115 publications

References 70 publications

Therapeutic Effect of Silybum marianum Plant Extract on Tamoxifen-Induced Fatty Liver in Rats

Therapeutic Effect of Silybum marianum Plant Extract on Tamoxifen-Induced Fatty Liver in Rats

Detoxification capacity and protective effects of medicinal plants (part 2): plant based review

The Effects of Chicory Leaf Aqueous Extract on Body Weight, Serum Glucose and Lipid Levels in Streptozotocin Induced Diabetic Rats

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