Ameliorating the Toxic Effects of Cypermethrin by Sesame Oil in Male Rabbits

Abstract

This study intended to evaluate the beneficial protective effects of sesame oil (SO) on cypermethrin (CYP)-induced sub chronic toxicity in rabbits. Male rabbits were divided into 4 groups: I: control; II: Cypermethrin (CYP, 48 mg/kg body weight, bw); III: CYP (48 mg/kg bw)+SO (1 ml/kg bw); and IV: SO (1 ml/kg bw). All treatments were orally administered three times per week for 9 weeks. CYP induced toxic effects on liver and kidney as revealed by a significant increase in serum liver enzyme activities with a significant decrease in total protein and albumin in addition to a significant increase in creatinine and uric acid levels. The effect of CYP on male fertility was demonstrated by a significant decrease in testis and epididymis weights, epididymis sperm counts, sperm motility with a significant increase in sperm abnormalities. Besides, a significant decrease in testosterone levels along with a significant increase in prolactin levels. CYP induced oxidative stress distinguished by a significant increase in malondialdehyde (MDA) levels in addition to a significant decrease in reduced glutathione (GSH) contents and superoxide dismutase (SOD) activity. Also, CYP produced a significant increase in sperm DNA damage. Co-treatment of SO with CYP improved all alterations induced by CYP. In conclusion SO has beneficial protective effects as it tends to dampen CYP sub chronic toxicity in male rabbit.Key words: sesame oil; cypermethrin; oxidative stress; male fertility; rabbit

Testicular Tissue Injury and Sperms Abnormalities Induced by Potassium Bromate and the Ameliorative Effect of Sesame Oil in Male Rats

“…Moreover, the results were in agreement with [21] who revealed that sesame oil might be beneficial against induced testes toxicity in adult male rats by ameliorate most of the fertility indices. In addition, the results similar to [22] who said that induced-sperm DNA damage, sperm motility, epididymis sperm counts and sperm abnormalities improved by sesame oil treatment in male rabbit through decreasing oxidative stress. The current research identified presence of histopathological changes in testes tissue when experimental animals administrated by potassium bromate at dose of 12 mg/kilogram of body weight for 21 days.…”

Cypermethrin induced apoptosis and testicular toxicity by upregulation of p53 in the brain and testis of male rats is alleviated by Sesame oil

“…S. oil enhanced T level, which may be because of the increase in cell viability. The increase in FSH and LH level may be because of the direct effect of S. oil on hypothalamus-pituitary axis [72]. Thus, the alleviated effect of S. oil against CYP toxicity may be associated with its ability to inhibit the lipid peroxidation and its antioxidant effect.…”