Ameliorating Effects of Short-Chain Inulin-Like Fructans on the Healing Stage of Trinitrobenzene Sulfonic Acid-Induced Colitis in Rats

Hino, Shingo; Ito, Hiroyuki; Bito, Hiroyuki; Kawagishi, Hirokazu; Morita, Tatsuya

doi:10.1271/bbb.110460

Cited by 8 publications

(6 citation statements)

References 44 publications

(53 reference statements)

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“…In animal models, fiber-supplemented diets consisting of short chain fructooligosacharides (SC-FOS) or short chain inulin-like fructans with degree 4 of polymerization (DP4), to a trinitrobenzene sulfonic acid (TNBS) model of rat colitis reduced intestinal inflammation, as was evidenced by reduced levels of TNF-α and NOS, while the proportion of Lactobacillus and Bifidobacterium increased [50,51,52]. In addition, administration of oral inulin reduced the severity of dextran sodium sulphate (DSS)-induced colitis in rats and increased proportions of Lactobacillus and Bifidobacterium in spontaneous colitis-developed transgenic rats treated with oligo-fructose enriched inulin (OF-IN) or FOS [53,54,55].…”

Section: The Role Of Diet and The Gut Microbiota In Intestinal Infmentioning

confidence: 99%

The Role of Gut Microbiota in Intestinal Inflammation with Respect to Diet and Extrinsic Stressors

et al. 2019

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The gut microbiota maintains a symbiotic relationship with the host and regulates several important functions including host metabolism, immunity, and intestinal barrier function. Intestinal inflammation and inflammatory bowel disease (IBD) are commonly associated with dysbiosis of the gut microbiota. Alterations in the gut microbiota and associated changes in metabolites as well as disruptions in the intestinal barrier are evidence of the relationship between the gut microbiota and intestinal inflammation. Recent studies have found that many factors may alter the gut microbiota, with the effects of diet being commonly-studied. Extrinsic stressors, including environmental stressors, antibiotic exposure, sleep disturbance, physical activity, and psychological stress, may also play important roles in altering the composition of the gut microbiota. Herein, we discuss the roles of the gut microbiota in intestinal inflammation in relation to diet and other extrinsic stressors.

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Section: The Role Of Diet and The Gut Microbiota In Intestinal Infmentioning

confidence: 99%

The Role of Gut Microbiota in Intestinal Inflammation with Respect to Diet and Extrinsic Stressors

et al. 2019

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“…The DP4 supplementation resulted in a decrease in MPO activity and an increase in Lactobacilli and Bifidobacteria counts. In addition, there was an increase in faecal SCFA concentrations, propionate in particular [ 25 ]. Supplementation of fructo-oligosaccharides (FOS) in HLA-B27 transgenic rats significantly reduced colitis and increased Bifidobacteria in all FOS-fed rats.…”

Section: Dietary Fibre In Animal Models Of Inflammatory Bowel Diseasementioning

confidence: 99%

The role of dietary fibre in inflammatory bowel disease

Pituch-Zdanowska¹,

Banaszkiewicz²,

Albrecht³

2015

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The aetiology of inflammatory bowel diseases (IBD), which are primarily Crohn's disease and ulcerative colitis, still remains unclear, while the incidence of IBD is constantly increasing, especially in the industrialised countries. Among genetic, environmental, and immunological factors, changes in the composition of the intestinal microflora and diet are indicated as very important in initiating and sustaining inflammation in patients with IBD. Above all nutrients dietary fibre is an especially important component of diet in the context of IBD. A potentially protective effect of high-fibre diet on intestinal disorders was described as early as in 1973. Several trials performed in animal models of IBD and human studies have reported that supplementation of some types of dietary fibre can prolong remission and reduce lesions of the intestinal mucosa during the course of the disease. This paper presents the current state of knowledge on the effects of dietary fibre in IBD.

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“…Prebiotics, which are believed to increase the preponderance of beneficial bacteria by supplying specific nutrients, increase cecal and fecal concentrations of SCFA [50-58]. Several human studies have reported increases in fecal SCFA after probiotic or prebiotic supplementation [54-58].…”

Section: Disease States Linked With Scfasmentioning

confidence: 99%

“…Synbiotics are a combination of probiotics and prebiotics [10]. While prebiotics may benefit animal models of colitis, results remain inconclusive, with effects dependant on the type of prebiotics and model of colitis used [10, 50, 51, 53, 59-69]. Similarly, the beneficial effects of probiotics in colitis models are strain dependent [52, 53, 70-73].…”

Section: Disease States Linked With Scfasmentioning

confidence: 99%

Pathobiology and Potential Therapeutic Value of Intestinal Short-Chain Fatty Acids in Gut Inflammation and Obesity

Soldavini

Kaunitz

2013

Dig Dis Sci

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Background The lumen of the gastrointestinal tract contains many substances produced from the breakdown of foodstuffs, from salivary, esophageal, intestinal, hepatic, and pancreatic secretions, and from sloughed cells present in the gastrointestinal lumen. Although these substances were traditionally regarded as waste products, there is increasing realization that many can be biologically active, either as signalling compounds or as nutrients. For example, proteins are broken down into amino acids, which are then sensed by nutrient receptors. The gut microbiome, which is at highest abundance in the ileocecum, has powerful metabolic activity, digesting and breaking down unabsorbed carbohydrates, proteins, and other ingested nutrients into phenols, amines, volatile organic compounds, methane, carbon dioxide, hydrogen, and hydrogen sulfide into volatile fatty acids, also called short-chain fatty acids (SCFAs). Conclusion These latter substances are the topic of this review. In this review, we will briefly discuss recent advances in the understanding SCFA production, signalling, and absorption, followed by a detailed description and discussion of trials of SCFAs, probiotics, and prebiotics in the treatment of gastrointestinal disease, in particular ulcerative colitis (UC), pouchitis, short bowel syndrome, and obesity.

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Ameliorating Effects of Short-Chain Inulin-Like Fructans on the Healing Stage of Trinitrobenzene Sulfonic Acid-Induced Colitis in Rats

Cited by 8 publications

References 44 publications

The Role of Gut Microbiota in Intestinal Inflammation with Respect to Diet and Extrinsic Stressors

The Role of Gut Microbiota in Intestinal Inflammation with Respect to Diet and Extrinsic Stressors

The role of dietary fibre in inflammatory bowel disease

Pathobiology and Potential Therapeutic Value of Intestinal Short-Chain Fatty Acids in Gut Inflammation and Obesity

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