Ameliorating Effects of Delphinol®, Anthocyanin Standardized Maqui Berry Extract, on Skin Brightness and Redness in Japanese Females: A Randomized Double-Blind Placebo-Controlled Pilot Study

Abstract

Maqui berries are wildly grown or cultivated in the Patagonian region in Chile. The berries contain large amounts of anthocyanins, especially delphinidin glycosides, which are strong anti-oxidants. We previously reported that standardized maqui berry extract, which contained lots of anthocyanins, has ameliorative effects against dry eyes and visible light-induced photoreceptor cell damage. However, the influence of maqui berry extract on the human skin has not been evaluated even though many skin troubles are related to active oxygen species. Therefore, we conducted a randomized double-blind placebo-controlled pilot study with Delphinol®, a maqui berry extract standardized for anthocyanins, especially delphinidins and cyanidins, in healthy Japanese female subjects. Capsules containing Delphinol® (60 mg) or placebo were orally administered to subjects aged 27 to 57 years old for eight weeks. Skin conditions [pigmentation, redness, skin tone, wrinkles, texture, oil content, water content, trans epidermal water loss (TEWL), collagen score, dermal thickness, and elasticity] were measured before and after intervention. In the Delphinol® group, the saturation significantly increased after eight weeks and reddish spots significantly decreased after four weeks of intake. The collagen score, which decreases with age, slightly increased with age by Delphi-nol® ingestion for eight weeks. Thus, the anthocyanin-standardized maqui berry extract Delphinol® increased skin brightness and collagen content, and improved facial skin redness. This study suggests that the daily oral intake of maqui berry extract can help maintain a healthy facial condition.

Delphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives

“…In another study, Delphinol ® (180 mg) lowered blood glucose level significantly and improved the blood lipid profile of prediabetic subjects [ 123 ]. A recent clinical study depicted the role of Delphinol ® in maintaining healthy skin conditions [ 124 ]. Thus, clinical testing of delphinidin’s anticancer potential is required for a reliable conclusion.…”

Ameliorating Effect of Crassocephalum rabens (Asteraceae) Extract on Skin Aging: A Randomized, Parallel, Double-Blind, and Placebo-Controlled Study

“…Skin hydration was remarkably improved in the treatment group, suggesting that dLGG could reduce oxidative stress and suppress hyaluronidase activity in skin cells [24]. Red areas result from sensitive skin, winter xerosis, alcohol ingestion, and UV radiation [36]. Since we did not recruit individuals with sensitive skin and conducted this study in spring, the study conditions might explain the insignificant change in red skin areas in the treatment group.…”

Anthocyanins Recovered from Agri-Food By-Products Using Innovative Processes: Trends, Challenges, and Perspectives for Their Application in Food Systems

“…Clinical trials have also demonstrated that anthocyanin supplementation can improve cardiovascular function [ 79 , 80 , 84 , 89 , 91 ], modulate gut microbiota composition [ 90 , 91 ], alleviate ulcerative colitis symptoms [ 67 ], enhance exercise recovery effectiveness [ 66 ], reduce ocular fatigue [ 92 ], and maintain a healthy skin facial condition [ 93 ]. Therefore, the consumption of anthocyanins-rich fruits/extracts showed beneficial effects on glucose and lipid metabolism, oxidative stress, inflammatory cascade, and gut microbiota profile and, thereby their daily intake may have a key role in the prevention or treatment of type 2 diabetes mellitus, obesity, dyslipidemias, metabolic syndrome, neurodegenerative disorders, cardiovascular diseases, cancers, and other chronic degenerative diseases, as well as in maintaining overall health and wellbeing.…”