Amelanotic malignant melanoma of the cervical oesophagus

Ramaswamy, Balakrishnan; Bhandarkar, Ajay M; Venkitachalam, Shruti; Trivedi, Shivangi

doi:10.1136/bcr-2014-204182

Cited by 3 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only one cases stated long survival ( 6 ). Other case reports stated a mean survival of approximately 9 months ( 7 – 15 ). Amelanotic malignant melanoma produces no melanin pigments, and accounts for approximately 2% of all malignant melanomas of the esophagus ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report

et al. 2018

View full text Add to dashboard Cite

The present case study reported of amelanotic malignant melanoma of the esophagus. A 68-year-old man underwent laparoscopic distal gastrectomy for early gastric cancer diagnosis. After gastrectomy, endoscopic examination revealed a protruded lesion lying adjacent to the melanosis area of the esophagus. Histology of the biopsy specimen suggested malignancy, but the diagnosis could not be made. The patient underwent trans-thoraco-abdominal curative subtotal esophagectomy. Immunohistochemical examination of the resected specimen was negative for HBM-45 and Melan-A. However, immunohistochemical examinations of SOX10 (Sry-related HMg-Box gene 10) and KBA.62, which are not associated with melanosome, were strongly positive, and tyrosinase was notably positive. A diagnosis primary of amelanotic malignant melanoma of the esophagus that consisted of only premelanosomes was made. The present findings suggest that, in the diagnosis of malignant melanoma, SOX10 and KBA.62 may be useful, particularly in diagnosing amelanotic malignant melanoma.

show abstract

Section: Discussionmentioning

confidence: 99%

A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Nonepithelial malignant tumors of the esophagus occur at a frequency of only 0.5 %, with carcinosarcoma being found most frequently, followed by MME 1 . AMME produces little or no melanin, and comprises approximately 10 % to 25 % of all MME 2 3 4 .…”

Section: Discussionmentioning

confidence: 99%

Slow-growing amelanotic malignant melanoma of the esophagus with long survival: a case report and review of the literature

et al. 2017

View full text Add to dashboard Cite

Background and study aims We report a case of amelanotic malignant melanoma of the esophagus (AMME), an exceedingly rare disease. A 77-year-old Japanese woman presented to our hospital with features suggestive of a middle esophageal submucosal tumor, which was diagnosed pathologically as AMME. The patient underwent thoracoscopic resection of the esophagus and laparoscopic gastric tube reconstruction. Three years after surgery, computed tomography showed no recurrence. Generally, the prognosis of malignant melanoma of the esophagus is very poor. However, our patient had no recurrence, and is alive 3 years after surgery and 5 years after the tumor was first detected.

show abstract

Primary amelanotic malignant melanoma of the esophagus: a case report

et al. 2019

View full text Add to dashboard Cite

BackgroundPrimary amelanotic malignant melanoma of esophagus, which is a subtype of primary malignant melanoma of the esophagus (PMME), is a very rare disease with a poor prognosis. We herein report a case of the amelanotic type of PMME.Case presentationAn 86-year-old woman was admitted to our hospital with symptoms of dysphagia. An endoscopic examination and constructed radiography revealed an elevated and semipedunculated lesion with an ulcer in the lower thoracic esophagus accompanied by another submucosal lesion of the esophagus. She was diagnosed with esophageal squamous cell carcinoma by a preoperative endoscopic biopsy. We performed thoracoscopy- and laparoscopy-assisted subtotal esophagectomy with lymphadenectomy. Based on the surgical specimens, although there were no melanocytes, we made a diagnosis of a malignant melanoma immunohistochemically; the tumor cells were positive for S-100 protein and HMB45 focally and partially for Melan-A.ConclusionWe experienced a case of primary amelanotic malignant melanoma, and the patient has remained disease-free for 1 year since the surgery. Since the diagnosis of amelanotic type of PMME is difficult, it should be made by the combination of a morphological examination, pathological examination, and immunohistochemistry.

show abstract

Amelanotic malignant melanoma of the cervical oesophagus

Cited by 3 publications

References 11 publications

A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report

A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report

Slow-growing amelanotic malignant melanoma of the esophagus with long survival: a case report and review of the literature

Primary amelanotic malignant melanoma of the esophagus: a case report

Contact Info

Product

Resources

About