Ambulatory Treatment of Duodenal Ulcers

Modern Drug Treatment for Peptic Ulcer

“…Synthetic anticholinergic drugs have been claimed to produce better symptomatic responses than atropine or placebo tablets (Ruffin & Cayer 1962), and tricyclamol and glycopyrronium have been claimed to reduce the chances of ulcer relapse and complications respectively (Sun 1962(Sun , 1964). By contrast a marginally better initial symptomatic response obtained with methantheline compared with a placebo was not maintained later (Friedlander 1954) and further trials conducted with glycopyrronium, and glycopyrronium or hyoscyamine in maximal doses, respectively showed no difference in the incidence of relapse, or the rate of symptomatic improvement when compared with the responses to dummy tablets (Trevino et al 1967, Kaye et al 1970); results which are in accord with others obtained using synthetic anticholinergic com-pounds (Melrose & Pinkerton 1961, Lennard Jones 1961.…”

Antacids and Allied Drugs

“…Though such a combination is successful in the relief of symptoms, several carefully studied series of patients so treated have shown no significantly better results than in cases treated with phenobarbitone or other simple measures (Friedlander, 1954;Doll and Pygott, 1952;Rowlands, 1952).…”

Medical Management of Peptic Ulcer With reference to anti-ulcer agents in other gastro-intestinal diseases

“…The use of olive oil does not appear to accentuate gastric ulcer healing (Friedlander, 1954;Taits, 1966), nor does excessive milk ingestion have a role in ulcer therapy (Piper, 1969). The literature regarding this has been previously reviewed (Piper, 1967 ;Langman , 1968) and will not be discussed further .…”