Ambulatory recorded ST segment depression on ECG is associated with lower cognitive function in healthy elderly men

Elmståhl, Sölve

doi:10.2147/ijgm.s5907

Cited by 2 publications

(2 citation statements)

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“…Furthermore, large LVIDd has been reported as an independent predictor for all-cause mortality or hospitalization for cardiac causes [32]. We have in an earlier study found that ambulatory ST segment depression, as a measure of ischemic heart disease (IHD), was associated with lower cognitive function, both visuospatial and verbal [14]. In our material, 144 subjects (68%), had a normal LVIDd, whereas 57 (27%) had enlarged.…”

Section: Discussionmentioning

confidence: 59%

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Cardiac ventricular dimensions predict cognitive decline and cerebral blood flow abnormalities in aging men

et al. 2013

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BackgroundThe aims of this study are to examine possible associations between left cardiac ventricular measures in sixth decade and cognitive performance, both cross sectionally and longitudinally, and to examine if left cardiac ventricular measures could predict future changes in cerebral blood flow (CBF).Methods211 elderly men from a cohort of the population study “Men born in 1914” completed M-mode echocardiography and a cognitive test battery at age 68. The cognitive test battery was repeated at age 81. CBF was estimated with 99mTc-HMPAO SPECT in 72 survivors at age 83. Cognitive performance at baseline and at 1st follow up and CBF at 1st follow up were analysed in relation to left ventricular internal dimension in diastole (LVIDd mm/m2) and fractional shortening (FS).ResultsSubjects with enlarged LVIDd at age 68 had poorer results on verbal and speed-performance tests at baseline and on verbal and visuo-spatial tests 14 years later on. Low FS was associated with decreased results on visuo-spatial tests at baseline. There was an inverse relationship between LVIDd and both verbal and spatial ability at the baseline and after 14 years of follow-up. Normotensive men with lower FS had also decreased CBF in a majority of brain areas 14 years later.ConclusionsMild echocardiographic abnormalities in 68 ys.-old men, as increased LVIDd and lower FS, are associated with lower cognitive test results and may predict cognitive decline and silent cerebral perfusion abnormalities 14 years later.

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Section: Discussionmentioning

confidence: 59%

“…The following year, at age 82–83, 72 survivors underwent CBF measurements. Background data were published previously [13,14]. Information on background factors was taken from the examination at the age of 68 years.…”

Section: Methodsmentioning

confidence: 99%