Ambulatory blood pressure profile in office normotensive obese children: prevalence of masked hypertension and impact of parental hypertension

Abstract

ObjectivesThe objectives of this study were to analyze ambulatory blood pressure (ABP) data in office normotensive obese children, to determine the prevalence and characteristics of masked hypertension (MH) and to investigate the impact of parental hypertension (PH) on ABP.MethodsSeventy-nine obese and 35 normal weight children were enrolled. Each weight group was further divided in accordance with the presence of PH. ABP was recorded in an outpatient setting.ResultsObese children had higher systolic ABP (p<0.05) and heart rate (p<0.001) compared with normal weight children. In obese children with PH, only nighttime systolic ABP (p=0.01) was higher compared with obese without PH, whereas normal weight children with PH had higher 24 h and daytime systolic and diastolic BP (all p<0.05) and nighttime DBP (p<0.001) compared with those without PH. PH but not obesity was associated with nondipping phenomenon. Prevalence of MH in the whole group was 23.6% being significantly higher in obese than in nonobese subjects (31.6 vs. 5.7%; p=0.0026) as well as in obese subjects with PH compared with obese subjects without PH (48.7 vs. 15%; χ2=10.37; p=0.001). MH was diagnosed more frequently in obese with high-normal office BP compared with obese with normal office BP, although it did not reach statistical significance (50 vs. 26.2%; χ2=3.631; p=0.056). In the normal weight group, neither PH nor office BP category had an impact on the prevalence of MH.ConclusionsOffice normotensive obese children had higher ABP values. MH was associated with obesity, PH and high-normal BP.

Obezite ve Kronik Böbrek Hastalığındaki İnflamasyonun Hemogram Parametreleri ile Değerlendirilmesi

“…It is a well-known fact that obesity is associated with higher blood pressure levels [22]. The role of inflammation in the pathophysiology of hypertension is suggested from the findings in the literature [23].…”