“…Accordingly, the altered expression of clock controlled genes found in HS fibroblasts could hinder normal output of the clock gene machinery ( BHLHE40, BHLHE41, NFIL3 ), and cellular activities, such as DNA transcription (CTNNB1, FOS, FOXL2, FOXO1, HIF1A, HSF1, ID2, JUN, KEAP1, KITLG, KLF10, PPARA, PPARD, PPARG, RARA, RXRA, SMAD4, SP1, SREBF1, SRF, STAT1, STAT5A) , post-translational modification and degradation ( FBXL3, SUMO3, USP5 ), lipid and glucose metabolism and biosynthetic pathways ( ACSL1, AEBP1, ALAS1, APBB1, APBB1IP, APBB2, BMPR1A, CREBBP, FASN, GYS1, HMGCR, INSIG2, LPIN1, NAMPT ), molecular processing ( ADA, ALDH1A1, ALDH1A3, ALDH1B1, ATF2, CES1, CES2, CYP7B1, E2F1, EGFR, EGR1, EIF2B3, HSP90AA1, HSPA1A, HSPA5, HSPD1, GLO1, GLUL, HK1, LDHA, LMAN1, LMAN2, MAOA, NPC1, PARP1, PCK2, PRDX2, PYGL, SGMS2 ), molecular transport ( AP2A1, AP2M1, IGFBP3, IGFBP5, LDLR, SLC22A15, SLC25A1, SLC27A1, SLC7A8, SLC9A3R2, SLC9A9 ), DNA damage response ( ATM, ATR, ATRIP ), endoplasmic reticulum stress and unfolded protein response ( XBP1 ), xenobiotic response ( AHR, ARNT ), autophagy ( BNIP3, CEBPB, GABARAPL1, ULK1 ), cell cycle control ( CCNA2, CCNB1, CCND1, CDK2AP1, CDKN1A, GADD45A, MDM2, WEE1 ), and tissue processes, such as inflammation, hemocoagulation and fibrinolysis ( ADAM17, A2M, FN1, ICAM1, IL6, ITGA5, MASP1, MGST1, NFKBIA, PDGFRA, PDGFRB, PTGS2, SERPINE1, SPP1, TFPI2, THBD, TRAF2,VEGFA ) [27-30,54]. …”