Ambulatory Blood Pressure Monitoring: Killing the Elephant to Get Its Hair? No More, Please!

Portaluppi, Francesco; Haus, Erhard; Smolensky, Michael H.

doi:10.3109/07420528.2012.715841

Cited by 3 publications

(2 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accordingly, the altered expression of clock controlled genes found in HS fibroblasts could hinder normal output of the clock gene machinery ( BHLHE40, BHLHE41, NFIL3 ), and cellular activities, such as DNA transcription (CTNNB1, FOS, FOXL2, FOXO1, HIF1A, HSF1, ID2, JUN, KEAP1, KITLG, KLF10, PPARA, PPARD, PPARG, RARA, RXRA, SMAD4, SP1, SREBF1, SRF, STAT1, STAT5A) , post-translational modification and degradation ( FBXL3, SUMO3, USP5 ), lipid and glucose metabolism and biosynthetic pathways ( ACSL1, AEBP1, ALAS1, APBB1, APBB1IP, APBB2, BMPR1A, CREBBP, FASN, GYS1, HMGCR, INSIG2, LPIN1, NAMPT ), molecular processing ( ADA, ALDH1A1, ALDH1A3, ALDH1B1, ATF2, CES1, CES2, CYP7B1, E2F1, EGFR, EGR1, EIF2B3, HSP90AA1, HSPA1A, HSPA5, HSPD1, GLO1, GLUL, HK1, LDHA, LMAN1, LMAN2, MAOA, NPC1, PARP1, PCK2, PRDX2, PYGL, SGMS2 ), molecular transport ( AP2A1, AP2M1, IGFBP3, IGFBP5, LDLR, SLC22A15, SLC25A1, SLC27A1, SLC7A8, SLC9A3R2, SLC9A9 ), DNA damage response ( ATM, ATR, ATRIP ), endoplasmic reticulum stress and unfolded protein response ( XBP1 ), xenobiotic response ( AHR, ARNT ), autophagy ( BNIP3, CEBPB, GABARAPL1, ULK1 ), cell cycle control ( CCNA2, CCNB1, CCND1, CDK2AP1, CDKN1A, GADD45A, MDM2, WEE1 ), and tissue processes, such as inflammation, hemocoagulation and fibrinolysis ( ADAM17, A2M, FN1, ICAM1, IL6, ITGA5, MASP1, MGST1, NFKBIA, PDGFRA, PDGFRB, PTGS2, SERPINE1, SPP1, TFPI2, THBD, TRAF2,VEGFA ) [27-30,54]. …”

Section: Discussionmentioning

confidence: 99%

Circadian transcriptome analysis in human fibroblasts from Hunter syndrome and impact of iduronate-2-sulfatase treatment

et al. 2013

View full text Add to dashboard Cite

BackgroundHunter syndrome (HS) is a lysosomal storage disease caused by iduronate-2-sulfatase (IDS) deficiency and loss of ability to break down and recycle the glycosaminoglycans, heparan and dermatan sulfate, leading to impairment of cellular processes and cell death. Cell activities and functioning of intracellular organelles are controlled by the clock genes (CGs), driving the rhythmic expression of clock controlled genes (CCGs). We aimed to evaluate the expression of CGs and downstream CCGs in HS, before and after enzyme replacement treatment with IDS.MethodsThe expression levels of CGs and CCGs were evaluated by a whole transcriptome analysis through Next Generation Sequencing in normal primary human fibroblasts and fibroblasts of patients affected by HS before and 24 h/144 h after IDS treatment. The time related expression of CGs after synchronization by serum shock was also evaluated by qRT-PCR before and after 24 hours of IDS treatment.ResultsIn HS fibroblasts we found altered expression of several CGs and CCGs, with dynamic changes 24 h and 144 h after IDS treatment. A semantic hypergraph-based analysis highlighted five gene clusters significantly associated to important biological processes or pathways, and five genes, AHR, HIF1A, CRY1, ITGA5 and EIF2B3, proven to be central players in these pathways. After synchronization by serum shock and 24 h treatment with IDS the expression of ARNTL2 at 10 h (p = 0.036), PER1 at 4 h (p = 0.019), PER2 at 10 h (p = 0.041) and 16 h (p = 0.043) changed in HS fibroblasts.ConclusionCG and CCG expression is altered in HS fibroblasts and IDS treatment determines dynamic modifications, suggesting a direct involvement of the CG machinery in the physiopathology of cellular derangements that characterize HS.

show abstract

Section: Discussionmentioning

confidence: 99%

Circadian transcriptome analysis in human fibroblasts from Hunter syndrome and impact of iduronate-2-sulfatase treatment

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Additionally, there is wide interindividual diurnal variability, and sleep-time blood pressure change may be normal, increased, decreased, or reversed. 3 Prospective studies have shown that mean 24-hour blood pressure is more predictive of subclinical organ damage 4,5 and CV events 6,7 than OBP. Furthermore, mean BP during sleep is superior to 24-hour blood pressure mean in this regard.…”

Section: N Introductionmentioning

confidence: 99%

Application and Effects of Ambulatory Blood Pressure Monitoring in Primary Care

Cummings

Ingham

Rosborough

2017

Journal of the Minneapolis Heart Institute Foundation

View full text Add to dashboard Cite

Ambulatory blood pressure monitoring (ABPM) is well-recognized as a valuable tool in diagnosing and managing hypertension and is more predictive of cardiovascular events than office or home blood pressure readings. Yet concerns remain, particularly in the US, about whether ABPM can be implemented in a primary care practice, be delivered in an efficient manner, and yield influential information. ABPM was made available within a 17-physician internal medicine primary care clinic and was utilized for routine blood pressure management. Patients wore the ABPM device for 24 hours, with readings taken every 20 to 30 minutes. Data were collected on 3,217 patients who underwent ABPM between January 2013 and October 2016. Of the 3,217 patients who underwent ABPM, 43% of patients had their blood pressure control status reclassified. Reclassification was not limited to near-normal office blood pressure readings. Among those with systolic blood pressure .160 mm Hg, 38% were reclassified as normotensive. Among those with systolic blood pressure, ,130 mmHg, 44% were reclassified as hypertensive. In those with discordant office and ABPM measurements, 48% had antihypertensive treatment altered. ABPM was efficiently implemented in a primary care clinic and was utilized by internal medicine physicians for routine management of blood pressure. Discordance between office blood pressure and ABPM was common, and nearly equally divided between underdiagnosis and overdiagnosis. Routine use of ABPM is feasible and has considerable potential to alter the diagnosis of hypertension and impact individual treatment. KEY WORDSblood pressure monitoring, ambulatory; hypertension; masked hypertension; white coat hypertension; primary health care

show abstract

Circadian and Cyclic Environmental Determinants of Blood Pressure Patterning and Implications for Therapeutic Interventions

Smolensky

Portaluppi

Hermida

2016

Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics

View full text Add to dashboard Cite

Ambulatory Blood Pressure Monitoring: Killing the Elephant to Get Its Hair? No More, Please!

Cited by 3 publications

References 71 publications

Circadian transcriptome analysis in human fibroblasts from Hunter syndrome and impact of iduronate-2-sulfatase treatment

Circadian transcriptome analysis in human fibroblasts from Hunter syndrome and impact of iduronate-2-sulfatase treatment

Application and Effects of Ambulatory Blood Pressure Monitoring in Primary Care

Circadian and Cyclic Environmental Determinants of Blood Pressure Patterning and Implications for Therapeutic Interventions

Contact Info

Product

Resources

About