Ambulatory blood pressure monitoring in chinese children with obstructive sleep apnea/hypopnea syndrome

Xu, Zhifang; Li, Bei; Shen, Kunling

doi:10.1002/ppul.22595

Cited by 38 publications

(44 citation statements)

References 32 publications

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“…It can be assumed that SDB affects night‐time blood pressure due to frequent arousals and sympathetic activation. Some previous studies have found elevated night‐time BP among children initially seeking treatment for SDB . We studied the impact of SDB on non‐dipping in a group of severely obese children without previous complaints of SDB, and found no associations between dipping and apnoea‐hypopnoea index, oxygen desaturation index and lowest oxygen saturation.…”

Section: Discussionmentioning

confidence: 77%

“…Another reason for non‐dipping in obesity could be a sympathetic activation due to sleep‐disordered breathing (SDB) causing sleep fragmentation and arousals. In some studies , but not all , children with SDB have been found to have impaired dipping compared to controls. However, the impact of disturbed sleep on dipping in obese children with no complaints of SDB has been studied less .…”

Section: Introductionmentioning

confidence: 99%

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Nocturnal blood pressure non‐dipping is prevalent in severely obese, prepubertal and early pubertal children

et al. 2013

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Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Nocturnal blood pressure non‐dipping is prevalent in severely obese, prepubertal and early pubertal children

et al. 2013

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“…This indicates that the underlying mechanisms for BP regulation partly change with the day-night shift, either via switching on or off of relevant genes or via a change in the amplitude of their expression. Since day-night shift is related to sleep behavior and sleep apnea has been associated with changes in nighttime BP levels [61–63], it is possible that genes responsible for sleep apnea also contribute to nighttime BP regulation. This needs to be confirmed by, e.g., multivariate modeling in twin and family studies.…”

Section: Influence Of Other Family Risk Factors On Familial Aggregatimentioning

confidence: 99%

Familial Aggregation and Childhood Blood Pressure

Wang

et al. 2014

Curr Hypertens Rep

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There is growing concern about elevated blood pressure (BP) in children. The evidence for familial aggregation of childhood BP is substantial. Twin studies have shown that a large part of the familial aggregation of childhood BP is due to genes. The first part of this review provides the latest progress in gene finding for childhood BP, focusing on the combined effects of multiple loci identified from the genome-wide association studies on adult BP. We further review the evidence on the contribution of the genetic components of other family risk factors to the familial aggregation of childhood BP including obesity, birth weight, sleep quality, sodium intake, parental smoking, and socioeconomic status. At the end, we emphasize the promise of using genomic-relatedness-matrix restricted maximum likelihood (GREML) analysis, a method that uses genome-wide data from unrelated individuals, in answering a number of unsolved questions in the familial aggregation of childhood BP.

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“…Four subsequent cross-sectional studies (class IV) identified a significant association [79][80][81][82], but one casecontrol study did not confirm this finding [83]. In a published consensus statement on childhood hypertension, polysomnography for the exclusion of OSAS in children presenting with hypertension and snoring is recommended [84].…”

Section: Literature Reviewmentioning

confidence: 99%

Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management

et al. 2015

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This document summarises the conclusions of a European Respiratory Society Task Force on the diagnosis and management of obstructive sleep disordered breathing (SDB) in childhood and refers to children aged 2-18 years. Prospective cohort studies describing the natural history of SDB or randomised, double-blind, placebo-controlled trials regarding its management are scarce. Selected evidence (362 articles) can be consolidated into seven management steps. SDB is suspected when symptoms or abnormalities related to upper airway obstruction are present (step 1). Central nervous or cardiovascular system morbidity, growth failure or enuresis and predictors of SDB persistence in the long-term are recognised (steps 2 and 3), and SDB severity is determined objectively preferably using polysomnography (step 4). Children with an apnoea-hypopnoea index (AHI) >5 episodes·h, those with an AHI of 1-5 episodes·h −1 and the presence of morbidity or factors predicting SDB persistence, and children with complex conditions (e.g. Down syndrome and Prader-Willi syndrome) all appear to benefit from treatment (step 5). Treatment interventions are usually implemented in a stepwise fashion addressing all abnormalities that predispose to SDB (step 6) with re-evaluation after each intervention to detect residual disease and to determine the need for additional treatment (step 7). @ERSpublications Management of obstructive sleep disordered breathing in childhood should follow a stepwise approach

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Ambulatory blood pressure monitoring in chinese children with obstructive sleep apnea/hypopnea syndrome

Abstract: OSAHS children had a higher nocturnal BP than non-OSAHS children and dysregulation of BP control reflected by decreased nocturnal BP dipping. Frequency of oxygen desaturation, apneas, and obesity were related to BP.

Cited by 38 publications

References 32 publications

Nocturnal blood pressure non‐dipping is prevalent in severely obese, prepubertal and early pubertal children

Nocturnal blood pressure non‐dipping is prevalent in severely obese, prepubertal and early pubertal children

Familial Aggregation and Childhood Blood Pressure

Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management

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