Ambulatory arterial stiffness index and renal abnormalities in primary hypertension

Ratto, Elena; Leoncini, Giovanna; Viazzi, Francesca; Vaccaro, Valentina; Falqui, Valeria; Parodi, Angelica; Conti, Novella; Tomolillo, Cinzia; Deferrari, Giacomo; Pontremoli, Roberto

doi:10.1097/01.hjh.0000244953.62362.41

Cited by 82 publications

(69 citation statements)

References 22 publications

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“…Nonetheless, recent studies have suggested that AASI has a prognostic value even beyond traditional risk factors. [6][7][8]33,34 Thus, evaluation of AASI could become an important diagnostic tool, provided further clinical and experimental studies confirm and ultimately validate it.…”

Section: Discussionmentioning

confidence: 97%

Metabolic syndrome and ambulatory arterial stiffness index in non-diabetic patients with primary hypertension

et al. 2007

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Increased arterial stiffness and the presence of metabolic syndrome (MS) have been shown to predict cardiovascular events in patients with primary hypertension. We investigated the relationship between a recently proposed index of arterial stiffness derived from ambulatory blood pressure (BP) monitoring and MS in 156 untreated, non-diabetic patients with primary hypertension. Ambulatory arterial stiffness index (AASI) was defined as 1 minus the regression slope of diastolic over systolic BP readings obtained from 24-h recordings. A modified National Cholesterol Education Program definition for MS was used, with body mass index replacing waist circumference. The prevalence of MS was 23%. Patients with MS were more frequently male (0.0291) and had increased serum uric acid (P ¼ 0.0005), high-sensitivity C-reactive protein (P ¼ 0.0259), as well as total and low-density lipoprotein (LDL)-cholesterol (P ¼ 0.0374 and P ¼ 0.0350, respectively) as compared to those without MS. After adjusting for these confounders, the association between AASI and the presence of MS was statistically significant (P ¼ 0.0257). Moreover, the prevalence of increased AASI (upper tertile, that is X0.550) was greater in patients with MS (P ¼ 0.0156). After adjusting for age and 24-h mean BP, the presence of MS entailed a more than twofold greater risk for increased AASI (0.0280). MS is associated with increased AASI in non-diabetic patients with primary hypertension. These data support the role of this new index of arterial stiffness as a marker of risk and help to explain the high cardiovascular morbidity and mortality that is observed in hypertensive patients with MS.

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Section: Discussionmentioning

confidence: 97%

Metabolic syndrome and ambulatory arterial stiffness index in non-diabetic patients with primary hypertension

et al. 2007

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“…1,2 A measure of this linear relationship, derived from ambulatory BP monitoring (ABPM), the Ambulatory Arterial Stiffness Index (AASI), 3 was recently shown to be associated with the metabolic syndrome, 4 with early signs of renal damage 5 and with other target organ damage 6 in patients with hypertension. In addition, AASI predicted prognosis, including cardiovascular and stroke mortality, 7,8 as well as stroke (but not cardiovascular events).…”

Section: Introductionmentioning

confidence: 99%

A modified ambulatory arterial stiffness index is independently associated with all-cause mortality

et al. 2008

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Dependence of the ambulatory arterial stiffness index (AASI) on data scattering interferes with its potential clinical relevance. We assessed the correlates and all-cause mortality associations of a modified AASI (s-AASI). AASI was derived from the 24-h diastolic vs systolic blood pressure linear regression line, whereas s-AASI was derived by symmetric regression (bisecting the line of diastolic vs systolic and systolic vs diastolic). Of 2918 patients 55% were women; age was 56 ± 16 years and body mass index was 27.3 ± 4.5 kg/m 2 . Average 24-h ambulatory blood pressure was 138±16/78±10 mm Hg.Applying the modified method for calculating AASI yielded a different measure: the negative correlation between AASI and blood pressure dipping (r ¼ À0.304, Po0.0001) was abolished (r ¼ þ 0.223, Po0.0001), s-AASI was more dependent on age (r ¼ 0.266 vs r ¼ 0.089 for AASI), and prediction of all-cause mortality was enhanced; hazard ratio (95% confidence intervals) 1.17 (1.00-1.36) per 1 s.d. increase in s-AASI in the fully adjusted model as compared with 1.15 (0.97-1.36) for AASI.

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“…Crosssectional studies in hypertensive subjects have shown that AASI is related with renal abnormalities, increased carotid intimamedia thickness and left ventricular hypertrophy. [5][6][7] However, 24-h pulse pressure, a simple surrogate measure of arterial stiffness that reflects the static difference between SBP and DBP, without considering the variability in their relationship, was better than AASI in predicting progression of albuminuria in elderly patients with type 2 diabetes. 8 AASI was found to predict an increased risk of cardiovascular mortality in a mixed cohort of hypertensive and normotensive patients.…”

Section: The Linear Relationship Between Sbp and Dbp: A New Marker Ofmentioning

confidence: 99%

The dynamic relationship between systolic and diastolic blood pressure: yet another marker of vascular aging?

Schillaci

Pucci

2010

Hypertens Res

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Ambulatory arterial stiffness index and renal abnormalities in primary hypertension

Abstract: Increased AASI is independently associated with early signs of renal damage in patients with sustained primary hypertension. These results strengthen the usefulness of AASI and ambulatory blood pressure monitoring in cardiovascular risk assessment.

Cited by 82 publications

References 22 publications

Metabolic syndrome and ambulatory arterial stiffness index in non-diabetic patients with primary hypertension

Metabolic syndrome and ambulatory arterial stiffness index in non-diabetic patients with primary hypertension

A modified ambulatory arterial stiffness index is independently associated with all-cause mortality

The dynamic relationship between systolic and diastolic blood pressure: yet another marker of vascular aging?

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