Ambulation-promoting effect of peppermint oil and identification of its active constituents

Umezu, Toyoshi; Sakamoto, Akiko; Ito, Hiroyasu

doi:10.1016/s0091-3057(01)00543-3

Cited by 101 publications

(89 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Menthol reduces the excitation of rat hippocampal neurons not only by enhancing the currents induced at low concentrations of GABA but also by directly activating the GABA A receptor [37]. In addition, menthol is known to act as a potent positive allosteric modulator of GABA A receptors via sites similar to those of propofol [23], suggesting that GABA A receptors are involved in the anesthetic response observed in the present experiment. In this study pretreatment with SR-95531, a selective GABA A receptor antagonist, appreciably prolonged the latency of the anesthetic response to menthol in medaka and goldfish, suggesting that the anesthetic effect of menthol on fishes is mediated at least in part by GABA A receptors.…”

Section: Discussionmentioning

confidence: 48%

See 1 more Smart Citation

Menthol Induces Surgical Anesthesia and Rapid Movement in Fishes

Kasai¹,

Hososhima²,

Yun-Fei³

2014

TONEURJ

View full text Add to dashboard Cite

Abstract:To determine whether fishes respond to menthol, Japanese medaka Oryzias latipes, goldfish Carassius auratus, and zebrafish Danio rerio were exposed to various types of menthol receptors agonists and the behavioral responses to these drugs were observed. Waterbone application of dl-menthol (0.5 mM) induced surgical anesthesia in 100% of medaka, 90% of goldfish, and 100% of zebrafish. The percentage of response increased dose-dependently from 0.2 mM to 0.5 mM. There were no differences in either percentage or latency of the response in surgical anesthesia among dl-, d-, and l-types of menthol. A high (3.0 mM) concentration of any of the three types of menthol induced rapid movement followed by the anesthetic response. Rapid movement was observed with allyl isothiocyanate, a cold nociceptor agonist, but not with icilin, a cold receptor agonist, in medaka and goldfish. Both allyl isothiocyanate and icilin failed to induce surgical anesthesia. To determine the involvement of -aminobutyric acid (GABA) system in menthol-induced surgical anesthesia, the effect of the receptors antagonist for the GABA A was tested. Pretreatment with a specific GABA A receptor antagonist prolonged the latency of the anesthetic response to menthol, but not to cold-water stimulation, in medaka and goldfish. These results demonstrate that menthol can play a role in the induction of surgical anesthesia in fishes, related at least in part to the activation of GABA A receptors, and of rapid movement possibly via cold nociceptors.

show abstract

Section: Discussionmentioning

confidence: 48%

“…In addition, intraperitoneal administration of menthol promoted ambulation in mice [23], suggesting that menthol could enter and influence a specific part of the brain. In the present study, applications of menthol to oral cavity and body surface completely failed to induce a surgical anesthetic response.…”

Section: Discussionmentioning

confidence: 98%

Menthol Induces Surgical Anesthesia and Rapid Movement in Fishes

Kasai¹,

Hososhima²,

Yun-Fei³

2014

TONEURJ

View full text Add to dashboard Cite

show abstract

“…A previous study (5) has demonstrated that peppermint oil promotes ambulation in ICR mice, indicating that the effect is similar to that of psychostimulants. In addition, we also demonstrated that the effect arises from its active constituents such as menthol, menthone, isomenthone, 1,8-cineol, (R)-(+)-pulegone, menthyl acetate, and caryophyllene, all of which promote ambulation in mice.…”

Section: Introductionmentioning

confidence: 80%

Evidence for the Involvement of Dopamine in Ambulation Promoted by Menthol in Mice

Umezu

Morita

2003

J Pharmacol Sci

Self Cite

View full text Add to dashboard Cite

Abstract. The present study examines the mechanism that underlies the ability of menthol (ME), a major constituent of peppermint oil, to promote mouse ambulation. We initially confirmed that bupropion (BUP), a dopamine (DA) uptake inhibitor, promotes ambulation in ICR mice. Since the subcutaneous administration of ME produced similar effects in mice, we investigated the effects of ME on ambulation when combined with BUP. The results showed that BUP potentiated the effect of ME on mouse ambulation. We then examined effects of the DA antagonists chlorpromazine, haloperidol, fluphenazine, spiperone, and SCH12679 on the ability of BUP and ME to promote ambulation. All of these DA antagonists attenuated the effects of BUP and ME. Prior exposure to reserpine, which depletes monoamines, caused decreased sensitivity to the ability of BUP and of ME in promoting ambulation. The tyrosine hydroxylase inhibitor amethyl-p-tyrosine, similarly decreased subsequent sensitivity to the effects of BUP and ME. These results suggest that DA is involved in the abilities of ME and BUP to promote ambulation in mice.

show abstract

“…Intraperitoneal administration of 1,8-cineol and caryophyllene significantly increased ambulatory activity in mice, suggesting that these chemicals possess pharmacological actions on behavior (Umezu et al, 2001). Cineole exhibited an antinociceptive activity comparable to that of morphine.…”

Section: Biological Activity Of Essential Oils Found In This Analysismentioning

confidence: 93%

Essential oils found in the smoke of "tira-capeta", a cigarette used by some quilombolas living in pantanal wetlands of Brazil

Negri¹,

Rodrigues²

2010

Rev. bras. farmacogn.

View full text Add to dashboard Cite

RESUMO: "Óleos essenciais encontrados na fumaça do ¨tira-capeta¨, um cigarro utilizado pelos quilombolas que vivem no pantanal do Brasil". Pesquisa etnofarmacológica realizada entre os quilombolas que vivem na Sesmaria Mata-Cavalos, no Estado de Mato Grosso, Brasil, um cigarro conhecido como ¨tira-capeta¨, foi citado por melhorar a memória e cognição, além de possuir outras indicações terapêuticas, tais como, "contra a sinusite", "para evitar resfriado", e "para aliviar problemas de insônia". No presente estudo, foi feita a caracterização dos óleos essenciais liberados durante o aquecimento das plantas utilizadas na confecção do cigarro, usando um método simples, rápido e livre de solvente baseado em cromatografia gasosa acoplada a espectrometria de massas usando "headspace" e microextração em fase sólida. Os principais constituintes encontrados foram 1,8-cineol, cânfora e α-pineno. Na tentativa de correlacionar a atividade biológica desses constituintes com as indicações terapêuticas relatadas pelos quilombolas, encontramos vários trabalhos realizados por diversos autores que mostraram que estes óleos possuem atividades similares às indicações terapêuticas relatadas pelos quilombolas.Unitermos: Etnofarmacologia, óleos essenciais, medicina popular, sistema nervoso central, quilombolas, memória. ABSTRACT: An ethnopharmacological survey developed among quilombolas living in SesmariaMata-Cavalos, in the State of Mato Grosso, Brazil; a cigarette known as "tira-capeta" (removingthe-devil), had been cited mainly "to improve memory and cognition", and also showed other therapeutical indications, such as: "against sinusitis", "to avoid cold", "to relieve sleep problems". The purpose of the present study was carried out a screening of essential oils delivered in the heating of plants used to produce the "tira-capeta" cigarette, using a simple, rapid and solvent-free method based on gas chromatography-mass spectrometry and headspace solid-phase microextraction. The principal essential oils found were 1,8 cineole, camphor and α-pinene. In the tentative to correlate these constituents with therapeutical indications reported by the quilombolas, were found some works carried out by many authors that corroborated the therapeutical indications reported by the quilombolas.

show abstract

Ambulation-promoting effect of peppermint oil and identification of its active constituents

Cited by 101 publications

References 17 publications

Menthol Induces Surgical Anesthesia and Rapid Movement in Fishes

Menthol Induces Surgical Anesthesia and Rapid Movement in Fishes

Evidence for the Involvement of Dopamine in Ambulation Promoted by Menthol in Mice

Essential oils found in the smoke of "tira-capeta", a cigarette used by some quilombolas living in pantanal wetlands of Brazil

Contact Info

Product

Resources

About