Ambrosia artemisiifolia as a Source of Biologically Active Substances

Abstract

A technology of obtaining biologically active substances from Ambrosia artemisiifolia has been analyzed and experimentally proved taking into account the vegetation stage. Use of the above-ground parts of the plant collected in the stage of budding as the starting raw material solves two important problems by (i) eliminating the source of the allergenic factor (pollen) and (ii) providing the maximum total yield of biologically active fractions, from which it is possible to isolate individual compounds. In the biologically active fractions isolated from the material collected in the budding stage, the main sesquiterpene lactones are cumanin and peruvin, while the other lactones are present in trace amounts. Pharmacological screening revealed active fractions, which are worthy of profound experimental investigation with respect to their influence on the systemic and regional hemodynamics.

New Sesquiterpenoids from Ambrosia artemisiifolia L.

“…Therefore, the planar structure of compound 2 was determined as guaia-4(5)-en-12,6-olide 9-O-β-D-glucoside. In the NOESY spectrum, there were no NOE correlations between H-6 and H-7, as well as the large values of the constants of J6,7 and J7,11 (10)(11), suggesting the presence of a trans-fused lactone ring [19]. Moreover, the correlations of H-7 with H-1 and H-9, and H-6 with H-11 and H3-14 revealed that protons H-7, H-1 and H-9 were cofacial, while H-6, H-11 and H3-14 were on the opposite side.…”

“…The extracts of this plant showed various bioactivities, such as molluscicidal [3], plant growth inhibitory [4], anti-inflammatory [5], antithrombin [6], antibacterial [7], insecticidal [8], hepatoprotective and hypolipemic activities [9]. On the other hand, the main chemical components of this species were identified as sesquiterpene lactones, which account for the antihelminthic, cardiotonic, antiinflammatory, analgesic, sedative (calming), antimalarial, anti-tumor, and other types of pharmacological activity [10,11]. As part of an ongoing search for novel bioactive compounds, we studied Ambrosia artemisiifolia L. growing in Hunan Province of China.…”

Invasive alien species: potential cheap resources of plant substances for medicinal use

“…2015;Kiss & al. 2017) as well as polyphenols and flavonoids (Parkhomenko & al. 2005(Parkhomenko & al.…”

“…2017) as well as polyphenols and flavonoids (Parkhomenko & al. 2005(Parkhomenko & al. , 2006Maksimovic 2008) or other constituents (Georgiev & al.…”

Phytochemical, pharmacological and toxicological studies of alkaloid- and sesquiterpene lactone-containing medicinal plants

“…Since the vast majority of pharmacological experiments deals with these compounds, the literature overview is limited to sesquiterpene lactones reported from A. artemisiifolia. According to literature data, 29 sesquiterpene lactones have been isolated from A. artemisiifolia (Fig 3) [ [187][188][189][190][191][192][193][194][195][196][197][198][199]. Although A. artemisiifolia is native to North America, the medicinal application of this species was marginal among Native Americans.…”