Amblyopia treatment outcomes

Scott, William E.; Kutschke, Pamela J.; Keech, Ronald V.; Pfeiffer, W.L.; Nichols, Bruce D.; Zhang, L.

doi:10.1016/j.ajo.2005.07.013

Cited by 13 publications

(20 citation statements)

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“…Occlusion amblyopia, or the development of amblyopia in the originally better-seeing, patched eye, is a risk commonly cited by opponents of FTO. Although the incidence of occlusion amblyopia in children treated with FTO is admittedly significant (19.3%, 16 25.8%, 14 ), it is almost always reversible 12 . Furthermore, after cessation of treatment, the final interocular difference in visual acuity was actually less in children with a history of occlusion amblyopia, suggesting that occlusion amblyopia can herald a better visual potential in the initially amblyopic eye 14, 16…”

Section: Introductionmentioning

confidence: 96%

Part-time versus full-time occlusion therapy for treatment of amblyopia: A meta-analysis

Yazdani

Sadeghi

Momeni‐Moghaddam

et al. 2017

Journal of Current Ophthalmology

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PurposeTo compare full-time occlusion (FTO) and part-time occlusion (PTO) therapy in the treatment of amblyopia, with the secondary aim of evaluating the minimum number of hours of part-time patching required for maximal effect from occlusion.MethodsA literature search was performed in PubMed, Scopus, Science Direct, Ovid, Web of Science and Cochrane library. Methodological quality of the literature was evaluated according to the Oxford Center for Evidence Based Medicine and modified Newcastle-Ottawa scale. Statistical analyses were performed using Comprehensive Meta-Analysis (version 2, Biostat Inc., USA).ResultsThe present meta-analysis included six studies [three randomized controlled trials (RCTs) and three non-RCTs]. Pooled standardized difference in the mean changes in the visual acuity was 0.337 [lower and upper limits: −0.009, 0.683] higher in the FTO as compared to the PTO group; however, this difference was not statistically significant (P = 0.056, Cochrane Q value = 20.4 (P = 0.001), I2 = 75.49%). Egger's regression intercept was 5.46 (P = 0.04). The pooled standardized difference in means of visual acuity changes was 1.097 [lower and upper limits: 0.68, 1.513] higher in the FTO arm (P < 0.001), and 0.7 [lower and upper limits: 0.315, 1.085] higher in the PTO arm (P < 0.001) compared to PTO less than two hours.ConclusionsThis meta-analysis shows no statistically significant difference between PTO and FTO in treatment of amblyopia. However, our results suggest that the minimum effective PTO duration, to observe maximal improvement in visual acuity is six hours per day.

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Section: Introductionmentioning

confidence: 96%

Part-time versus full-time occlusion therapy for treatment of amblyopia: A meta-analysis

Yazdani

Sadeghi

Momeni‐Moghaddam

et al. 2017

Journal of Current Ophthalmology

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“…Younger patients have a better overall outcome and require less treatment time to reach their visual potential. 46,[50][51][52] Specifically, evidence suggests that detection of amblyopia before age three years is associated with better outcome. 3,14,46,53 This is particularly significant considering that most vision screening programs are designed for children aged three years and older.…”

Section: Maximizing Efficacy Of Amblyopia Therapymentioning

confidence: 97%

“…The worse the vision at diagnosis, the worse the outcome, 1, 50-52 and the longer it takes to reach visual potential. 46 Detecting and treating amblyopia before age three years may be a goal for the future, but today many amblyopic children are presenting to the ophthalmologist at much older ages. This raises the question: when is it too late to treat amblyopia?…”

Section: Maximizing Efficacy Of Amblyopia Therapymentioning

confidence: 99%

Current Recommendations for Amblyopia Treatment

Arnoldi

2007

American Orthoptic Journal

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“…He reported in his retrospective chart review, that he had found that full-time patching for amblyopia led to 50% of his patients achieving 20/20, 96% achieving > 20/30, and 97% achieving > 20/40. 5 With patients with strabismic amblyopia, ATS1 also showed that amblyopia therapy is associated with deterioration of alignment from orthotropia, with a 14% risk of microstrabismus (16% in the patching group, 10% in the atropine group), and a 3% risk of a > 8 Δ tropia. Amblyopia therapy alone was associated with a 14% chance of resolution of a tropia > 8 Δ , and a 36% chance of any resolution at least to a microtropia.…”

Section: Introductionmentioning

confidence: 95%