Amblyopia and fixation eye movements

Ghasia, Fatema F.; Wang, Jingyun

doi:10.1016/j.jns.2022.120373

Cited by 16 publications

(10 citation statements)

References 178 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Research on eye movements has indeed existed for more than a century, and infrared video eye trackers capabilities, accuracy, and accessibility have renewed the interest on eye movements to clinicians and psychologists. FEM have been explored in neurological disorders such as amblyopia 53,54 , schizophrenia 55 , Parkinson’s disease 56 , and others 57 . There have also been attempts to reveal new FEM-based biomarkers to predict multiple sclerosis and follow its progression 58 .…”

Section: Discussionmentioning

confidence: 99%

“…They have mostly been studied in neurological disorders such as amblyopia (Shaikh 2016[16]), schizophrenia (Egana 2013[17]), Parkinson’s disease (Kaski 2017[18]) and few more (Alexander 2018[19]). Recent attempts to reveal new biomarkers from FEM have relied on microsaccadic intrusions to predict multiple sclerosis and follow its development (Sheehy 2020[20]) or fixation abnormalities in amblyopia to follow treatment efficiency (Ghasia 2022[21]).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Foveolar drusen decrease fixation stability in pre-symptomatic AMD

Murari,

Gautier,

Daout

et al. 2023

Preprint

View full text Add to dashboard Cite

PurposeWe conducted a clinical study to characterize fine spatiotemporal alterations of FEM in controls and patients with pre-clinical signs of age-related macular degeneration (AMD).MethodsTwenty-seven participants were recruited from the SilverSight cohort of the Vision Institute - Quinze-Vingts National Vision Hospital, Paris. Subjects were included in three groups: healthy young, healthy aging controls, and aging subjects with drusen. Detection of microdrusen was done using gaze-dependent adaptive optics ophthalmology. Monocular retinal tracking was based on adaptive optics flood illumination ophthalmoscopy (AO-FIO). The system allows for sub-arcminute resolution, high-speed, distortion-free imaging of the foveal area. Local stimulation through digital micromirror (DMD) projection from a near infrared source enabled projection of optotypes. Eye movements were estimated using a phase-correlation registration algorithm.ResultsCompared to controls, patients with foveal drusen showed higher microsaccade amplitude, higher drift diffusion coefficient, and worse fixation stability -i.e. higher isoline area. Among the drusen group, the increase of microsaccade amplitude and ISOA was correlated with drusen eccentricity; the closer the drusen were to the center of the fovea, the more unstable were FEM.ConclusionsWe demonstrate the clinical interest of a novel high-precision retinal tracking technique to characterize FEM changes at the microscopic level. We found significant differences between the drusen group and both healthy young and older adult groups. Central drusen altered fixation stability characteristics, resulting in compensatory FEM changes. High speed, high resolution FEM analysis may help to define the functional signatures of early age-related changes.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Foveolar drusen decrease fixation stability in pre-symptomatic AMD

Murari,

Gautier,

Daout

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Discordant visual signals from the two eyes have a major effect on the primary visual cortex V1 neurons during the early critical period of development, altering neural circuitry [11,14,16,20,21]. Beyond infancy, the effect of dissimilar visual input results in fixation instability, with the development of abnormal fixation eye movements (FEMs), eccentric fixation, and greater VA loss [2,20,22]. The presence of nystagmus in amblyopic patients is associated with more severe visual impairment [20].…”

Section: Pathogenesismentioning

confidence: 99%

Current Developments in the Management of Amblyopia with the Use of Perceptual Learning Techniques

Tsaousis,

Mousteris,

Diakonis

et al. 2023

Medicina

View full text Add to dashboard Cite

Background and Objectives: Amblyopia is a neurodevelopmental disorder caused by interocular suppression of visual input, affecting visual acuity, stereopsis, contrast sensitivity, and other visual functions. Conventional treatment comprises occlusion of the sound eye. In recent years, novel therapies that deploy perceptual learning (PL) principles have been introduced. The purpose of this study is to assess the latest scientific data on this topic. Materials and Methods: For this purpose, we conducted a literature search for relevant studies published during the previous 4 years (2020–2023). Results: A plethora of visual perceptual learning protocols have been recently developed. Dichoptic video games, contrast rebalanced movies, and online perceptual training platforms are the main formats. Perceptual learning activates neuroplasticity, overcomes interocular suppression, and improves the visual impairments induced by amblyopia. Conclusions: This novel treatment is effective in both children and adults, as well as in patients non-responding to patching.

show abstract

“…The impaired visual functions are considered to result from anisometropia, strabismus or other amblyogenic factors that interfere with normal development of the visual pathways during the first years of life (Birch, 2013; Birch & Kelly, 2023; Hunter & Cotter, 2018). Apart from low visual acuity, amblyopia is also accompanied by oculo‐motor deficits (Chung et al, 2015; Ghasia & Wang, 2022), extremely interocular imbalance (Ding, Klein, et al, 2013; Huang et al, 2011) and interocular suppression (Li et al, 2011; Mansouri et al, 2008), decreased contrast sensitivity (Bradley & Freeman, 1981), impaired motion perception (El‐Shamayleh et al, 2010), loss of stereoacuity (Levi et al, 2015), and other monocular and binocular visual dysfunctions (Hamm et al, 2014; Levi, 2020; Spang & Fahle, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…acuity, amblyopia is also accompanied by oculo-motor deficits (Chung et al, 2015;Ghasia & Wang, 2022), extremely interocular imbalance (Ding, Klein, et al, 2013;Huang et al, 2011) and interocular suppression (Li et al, 2011;Mansouri et al, 2008), decreased contrast sensitivity (Bradley & Freeman, 1981), impaired motion perception (El-Shamayleh et al, 2010), loss of stereoacuity (Levi et al, 2015), and other monocular and binocular visual dysfunctions (Hamm et al, 2014;Levi, 2020;Spang & Fahle, 2009).…”

mentioning

confidence: 99%

Treating amblyopia using altered reality enhances the fine‐scale functional correlations in early visual areas

Dong,

Liu,

et al. 2023

Human Brain Mapping

View full text Add to dashboard Cite

Amblyopia is a developmental visual disorder that causes substantial visual deficits. Studies using resting‐state functional magnetic resonance imaging have disclosed abnormal brain functional connectivity (FC) both across long‐range cortical sites and within the visual cortex in amblyopes, which is considered to be related to impaired visual functions. However, little work has examined whether restoring the vision of amblyopes accompanies with an improvement of FC. Here in adult amblyopes and healthy participants, we compared their brain FC before and after an altered‐reality adaptation training. Before the training, the voxel‐wise FCs of amblyopia patients were substantially weaker than those of healthy control participants both within and across the early visual areas. After the training, visual acuities improved in amblyopes but not in the control participants. The effect kept strengthening in the subsequent month without further adaptation. Importantly, we observed enhanced voxel‐wise FC both within and across the early visual areas of amblyopes. Moreover, the enhancement continued for at least 1 month. These results suggest that the effective treatment can improve both the amblyopes' vision and functional connections in the visual cortex.

show abstract

Amblyopia and fixation eye movements

Cited by 16 publications

References 178 publications

Foveolar drusen decrease fixation stability in pre-symptomatic AMD

Foveolar drusen decrease fixation stability in pre-symptomatic AMD

Current Developments in the Management of Amblyopia with the Use of Perceptual Learning Techniques

Treating amblyopia using altered reality enhances the fine‐scale functional correlations in early visual areas

Contact Info

Product

Resources

About