Ambler Class A Extended-Spectrum β-Lactamases in
            <i>Pseudomonas aeruginosa</i>
            : Novel Developments and Clinical Impact

Weldhagen, Gerhard F.; Poirel, Laurent; Nordmann, Patrice

doi:10.1128/aac.47.8.2385-2392.2003

Cited by 209 publications

(180 citation statements)

References 56 publications

Supporting

Mentioning

155

Contrasting

Unclassified

Order By: Relevance

“…were reported to carry PER-1 in various countries including Korea [30]. PER-1 was reported to be transferable to various Gram-negative bacteria [3], and strains carrying PER-1 and metallo-b-lactamase or OXAtype ESBL have also been isolated [12,31].…”

Section: Discussionmentioning

confidence: 99%

“…The genes for five types of ESBL (PER, VEB, GES, SHV and TEM-types) were detected by polymerase chain reaction (PCR), which was performed using the primers described by Weldhagen et al [3]. The complete PER-1 gene was amplified by using two primers, which correspond to N-terminal or C-terminal regions, followed by determination of the nucleotide sequence by the direct sequencing method.…”

Section: Detection Of Esbl Genesmentioning

confidence: 99%

“…There have been few reports on the production of ESBL in P. aeruginosa, but some ESBLs are known to cause high resistance in P. aeruginosa [3]. The presence of genes for various ESBLs having the ability to hydrolyze ceftazidime was investigated using PCR.…”

Section: Detection Of Per-1 Productionmentioning

confidence: 99%

“…Hence, ESBL production caused high resistance to various b -lactam antibiotics, which is a serious problem in clinic. Although the production of ESBL has been reported primarily in Enterobacteriaceae, there are few reports on the isolation of ESBL-producing P. aeruginosa [3]. PER-1-type blactamase was first detected as an ESBL in P. aeruginosa and was reported to hydrolyze various b-lactams except for imipenem, oxacillin and cephamycins [4,5].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Occurrence of PER-1 Producing Clinical Isolates of Pseudomonas aeruginosa in Japan and their Susceptibility to Doripenem

et al. 2006

View full text Add to dashboard Cite

The acquisition of resistance by extendedspectrum b-lactamases (ESBL) has been reported primarily for Enterobacteriaceae, but there are few reports on the isolation of ESBL-producing Pseudomonas aeruginosa. PER-1-type ESBL producing P. aeruginosa has been found in various regions around the world but there are no reports of clinical isolates in Japan. During our susceptibility surveillance studies over a 10 year period, we found four clinical isolates resistant to ceftazidime due to production of PER-1. They were resistant to ceftazidime but susceptible in the presence of clavulanic acid, a class A b -lactamase inhibitor. The strains had the ability to hydrolyze ceftazidime. They also had the gene for PER-1-type ESBL. This is the first report of the isolation of PER-1 producing strains in Japan. These four strains were resistant to ceftazidime, cefepime and aztreonam with MICs of 64 mg/ml or more, but were more susceptible to carbapenem antibiotics. In particular, doripenem, which is a novel carbapenem antibiotic, showed good antibacterial activity with a MIC of 2 or 4 mg/ml, which was more potent than meropenem and imipenem. Doripenem also showed good therapeutic efficacy against a systemic infection of mice with a PER-1 producing strain, and was also more potent in vivo than imipenem or meropenem.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Detection Of Esbl Genesmentioning

confidence: 99%

Section: Detection Of Per-1 Productionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Occurrence of PER-1 Producing Clinical Isolates of Pseudomonas aeruginosa in Japan and their Susceptibility to Doripenem

et al. 2006

View full text Add to dashboard Cite

show abstract

“…ESBLs include: β-lactamases class A TEM SHV, CTX-M β-lactamases (class D), and OXA β-lactamases (PER, VEB, GES and IBC) (14). OXA β-lactamase inhibitors have long been known as being relatively rare, but localized in plasmids with the ability to hydrolyze oxacillin and similar anti-staphylococcal penicillin.…”

Section: Activity Of β-Lactamasesmentioning

confidence: 99%

Resistance in Staphylococcus Aureus: The Never-Ending Story

Orlović¹,

Miljković-Selimović²,

Dinić³

et al. 2016

Acta Facultatis Medicae Naissensis

View full text Add to dashboard Cite

SUMMARYCombating Staphylococcus aureus (S. aureus) infections using antibacterial drugs is actually an ongoing effort to overcome resistance mechanism of this microorganism. In this paper, we discussed (1) the mechanisms of resistance to some of the most commonly used antimicrobial agents in the treatment of S. aureus: methicillin, vancomicyn and quinolones. In addition, (2) efflux pump mechanisms involved in maintaining homeostasis in the presence of compounds that inhibit S. aureus growth and reproduction, as well as mechanisms of resistance to a number of antibiotics, have been reviewed.

show abstract

Pseudomonas

Abdelraouf¹,

Tam²

2017

Antimicrobial Drug Resistance

View full text Add to dashboard Cite

Ambler Class A Extended-Spectrum β-Lactamases in Pseudomonas aeruginosa : Novel Developments and Clinical Impact

Cited by 209 publications

References 56 publications

Occurrence of PER-1 Producing Clinical Isolates of Pseudomonas aeruginosa in Japan and their Susceptibility to Doripenem

Occurrence of PER-1 Producing Clinical Isolates of Pseudomonas aeruginosa in Japan and their Susceptibility to Doripenem

Resistance in Staphylococcus Aureus: The Never-Ending Story

Pseudomonas

Contact Info

Product

Resources

About