Ambient temperature-dependent thermoregulatory role of REM sleep

Kumar, Deependra; Kumar, Velayudhan Mohan; Mallick, Hruda Nanda

doi:10.1016/j.jtherbio.2012.02.005

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…Three different sets of temperatures (first set: 18, 24, and 27°C; second set: 24, 27, and 30°C; and third set: 27, 30, and 33°C) were employed to study the thermal preference while looking into the influence of T amb on sleep architecture. Using this chamber it was found that the rats preferred to stay at 27°C, while the maximum sleep was obtained at 29–30°C (Ray et al, 2004 , 2005 ; Kumar et al, 2009 , 2012 ).…”

Section: Thermoneutral Temperature and Sleepmentioning

confidence: 99%

“…As mentioned earlier, when the rats were exposed to 27, 30, and 33°C, the rats had maximum sleep at 30°C, though they preferred to stay at 27°C. When both peripheral and central warm receptors, were destroyed in these rats (by systemic administration of capsaicin), the selective increase in REM sleep at 30°C was not seen (Kumar et al, 2012 ). When peripheral warm receptors were selectively destroyed by neonatal treatment of capsaicin, the central warm receptors were able to mediate an increase in TST with increasing T amb , even in the absence of peripheral warm receptors (Gulia et al, 2005 ).…”

Section: Role Of Thermoreceptors In Ambient Temperature Related Sleepmentioning

confidence: 99%

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Basal Forebrain Thermoregulatory Mechanism Modulates Auto-Regulated Sleep

Mallick¹,

Kumar²

2012

Front. Neur.

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Regulation of body temperature and sleep are two physiological mechanisms that are vital for our survival. Interestingly neural structures implicated in both these functions are common. These areas include the medial preoptic area (POA), the lateral POA, the ventrolateral POA, the median preoptic nucleus, and the medial septum, which form part of the basal forebrain (BF). When given a choice, rats prefer to stay at an ambient temperature of 27°C, though the maximum sleep was observed when they were placed at 30°C. Ambient temperature around 27°C should be considered as the thermoneutral temperature for rats in all sleep studies. At this temperature the diurnal oscillations of sleep and body temperature are properly expressed. The warm sensitive neurons of the POA mediate the increase in sleep at 30°C. Promotion of sleep during the rise in ambient temperature from 27 to 30°C, serve a thermoregulatory function. Autonomous thermoregulatory changes in core body temperature and skin temperature could act as an input signal to modulate neuronal activity in sleep-promoting brain areas. The studies presented here show that the neurons of the BF play a key role in regulating sleep. BF thermoregulatory system is a part of the global homeostatic sleep regulatory mechanism, which is auto-regulated.

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Section: Thermoneutral Temperature and Sleepmentioning

confidence: 99%

Section: Role Of Thermoreceptors In Ambient Temperature Related Sleepmentioning

confidence: 99%

Basal Forebrain Thermoregulatory Mechanism Modulates Auto-Regulated Sleep

Mallick¹,

Kumar²

2012

Front. Neur.

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“…Preference for temperature. Some studies found a clear and significant preference for a particular temperature in rats, such as a preference for 27°C (versus 30°C and 33°C) 57,58 , a preference for 24°C (versus 18°C and 30°C) 59 , and a preference for 19.2+/-5.2°C when placed in a temperature gradient from 10°C to 40°C 60 . However, the majority of the identified studies investigating thermopreference found that preference depended on a moderating factor.…”

Section: Refinements That Have Been Studied?mentioning

confidence: 99%

A mapping review of refinements to laboratory rat housing and husbandry

et al. 2023

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Refining the housing and husbandry of laboratory rats is an important goal, both for ethical reasons and to allow better quality research. We conducted a mapping review of 1,017 studies investigating potential refinements of housing and husbandry of the laboratory rat to assess what refinements have, and haven't, been studied, and to briefly assess whether there is evidence to support any impact on rat welfare. Among the many refinements studied, the majority involve changes to the cage, but some also involve alterations to the wider environment. The effects of these refinements were assessed using a range of readouts, many of which are difficult to interpret from a welfare perspective. Preference studies, which are easier to interpret, provide evidence that rats prefer complex environments, including shelters and multiple objects, which offer different areas/resources allowing the rat to engage in diverse behaviours. The reporting of methodology in papers was often poor, indicating that studies were potentially subject to biases. Given that many refinements co-occurred, it was often difficult to tease apart which ones were most beneficial for rat welfare. Effects of refinements were also moderated by a number of factors including age, sex, strain, and photoperiod. Altogether our findings show that a one-size-fits-all approach to refinements is not appropriate, because different refinements will impact different rats in different ways. Our review has also produced a database of >1,000 articles that can be used for further and more detailed analyses. Our findings have also highlighted areas where future research is likely to be valuable, including refinements to rat transport, handling, and the use of training.

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“…It showed that the REM sleep generation is under inhibitory control of the WSN of the POA. In another paper titled "Ambient temperature-dependent thermoregulatory role of REM sleep" published in 2012 in the Journal of Thermal Biology, they studied thermoregulation and sleep after the destruction of both peripheral and central warm receptors, by systemic administration of capsaicin [8]. Results of this study showed that the ambient temperaturerelated increase in REM sleep at higher atmospheric temperature could be part of the thermoregulatory measures.…”

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confidence: 99%

Why Indian Scientific Contributions do not Fetch Nobel Prize

Kumar

Pandi-Perumal

2021

Sleep Vigilance

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On 4th October 2021, the announcement came that David Julius, along with Ardem Patapoutian, bagged the Nobel Prize in medicine for this year for their work on capsaicin receptors in the skin that sense temperature and touch [1]. Main headline of one national newspaper on 5th October was "Indian lab may have helped validate research that fetched the medicine Nobel." It stated that The Indian Institute of Chemical Biology (IICB) under the CSIR had shown in 2018 that the cells of the immune system may also be critically dependent on these capsaicin channels to sense the physical cues they encounter inside the body [2]. The scientific community, journals, administrators, and politicians need to look critically at such claims and counterclaims for introspection and futuristic measures. As Sleep and Vigilance is a sleep-related journal, we are taking some sleeprelated contributions from India on the subject of capsaicin for which the Nobel Prize in medicine for 2021 was awarded. Julius told Scientific American in 2019 that he got the idea to study chili peppers after a trip to the grocery store. "I was looking at these shelves and shelves of basically chili peppers and extracts (hot sauce) and thinking, 'This is such an important and such a fun problem to look at. I've really got to get serious about this'," he said [3].According to a statement by the Nobel Assembly, David Julius utilized capsaicin, a pungent compound from chili peppers that induces a burning sensation, to identify a sensor in the nerve endings of the skin that responds to heat. Ardem Patapoutian identified two mechanically activated ion channels, named Piezo1 and Piezo2. He uncovered the central roles of Piezo1 and Piezo2 for many additional physiological

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Ambient temperature-dependent thermoregulatory role of REM sleep

Cited by 4 publications

References 21 publications

Basal Forebrain Thermoregulatory Mechanism Modulates Auto-Regulated Sleep

Basal Forebrain Thermoregulatory Mechanism Modulates Auto-Regulated Sleep

A mapping review of refinements to laboratory rat housing and husbandry

Why Indian Scientific Contributions do not Fetch Nobel Prize

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