Ambient sulphur dioxide exposure and emergency department visits for migraine in Vancouver, Canada

Szyszkowicz, Mieczysław; Rowe, Brian H.; Kaplan, Gilaad G.

doi:10.2478/v10001-009-0006-7

Cited by 34 publications

(33 citation statements)

References 17 publications

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“…It has also been linked to nervous system disorders such as stroke and headache [16,17]. Cakmak et al have demonstrated the positive relationship between SO 2 and epilepsy [12], which was consistent with our findings.…”

Section: Discussionsupporting

confidence: 92%

The Novel Relationship between Urban Air Pollution and Epilepsy: A Time Series Study

Fan

Kan

et al. 2016

PLoS ONE

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Background and purposeThe data concerning the association between environmental pollution and epilepsy attacks are limited. The aim of this study was to explore the association between acute air pollution exposure and epilepsy attack.MethodsA hospital record-based study was carried out in Xi’an, a heavily-polluted metropolis in China. Daily baseline data were obtained. Time-series Poisson regression models were applied to analyze the association between air pollution and epilepsy.ResultsA 10 μg/m3 increase of NO2, SO2, and O3 concentrations corresponded to 3.17% (95%Cl: 1.41%, 4.93%), 3.55% (95%Cl: 1.93%, 5.18%), and -0.84% (95%Cl: -1.58%, 0.09%) increase in outpatient-visits for epilepsy on the concurrent days, which were significantly influenced by sex and age. The effects of NO2 and SO2 would be stronger when adjusted for PM2.5. As for O3, a -1.14% (95%Cl: -1.90%, -0.39%) decrease was evidenced when adjusted for NO2. The lag models showed that the most significant effects were evidenced on concurrent days.ConclusionsWe discovered previously undocumented relationships between short-term air pollution exposure and epilepsy: while NO2 and SO2 were positively associated with outpatient-visits of epilepsy, O3 might be associated with reduced risk.

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Section: Discussionsupporting

confidence: 92%

The Novel Relationship between Urban Air Pollution and Epilepsy: A Time Series Study

Fan

Kan

et al. 2016

PLoS ONE

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“…For each air pollution variable we have 24 measurements recorded at hourly intervals. These include data on gaseous pollutants: SO 2 , carbon monoxide (CO), nitrogen oxide (NO 2 ), ozone (O 3 ), and particulate matter data: respirable particles PM 2.5 and inhalable PM 10 , particulate matter of median aerodynamic diameter less than 2.5 and 10 microns, respectively. The daily shared exposures of the population were expressed as mean values among stations in city (Table 2).…”

Section: Air Pollution Datamentioning

confidence: 99%

“…For each lagged values a separate model was constructed. Our analysis represents the percentage value of changes in relative risk (%RR) with 95% confidence intervals (CI) associated with an increase in average of pollutant concentrations of the exposure to the study pollutants (SO 2 , NO 2 , CO, O 3 , PM 10 , and PM 2.5 ) after adjusting for temperature and relative humidity. Estimates whose 95% CI do not cross 0 are considered significant.…”

Section: O R I G I N a L P A P E R S Ijomeh 2009;22(3) 237mentioning

confidence: 99%

“…Headaches were more commonly reported from a neighbourhood with a pulp mill, with higher sulphur dioxide (SO 2 ) emissions, compared to one without [8]. Moreover, large scale ED studies have demonstrated an association between air pollution and ED visits for migraine and all headaches in Edmonton [9], Vancouver [10], and Ottawa [11,12]. The associations were most consistent for particulate matter; however, these results require confirmation and also further explorations using larger databases.…”

Section: Introductionmentioning

confidence: 99%

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Emergency department visits for migraine and headache: a multi-city study

Szyszkowicz¹,

Kaplan²,

Grafstein³

et al. 2009

International Journal of Occupational Medicine and Environmental Health

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Objectives: We set out to examine associations between ambient air pollution concentrations and emergency department (ED) visits for migraine/headache in a multi-city study. Materials and Methods: We designed a time-series study of 64 839 ED visits for migraine (ICD-9: 346) and of 68 495 ED visits for headache (ICD-9: 784) recorded at hospitals in five different cities in Canada. The data (days) were clustered according to the hierarchical structure (location, year, month, day of week). The generalised linear mixed models technique was applied to fit the logarithm of clustered daily counts of ED visits for migraine, and separately for headache, on the levels of air pollutants, after adjusting for meteorological conditions. The analysis was performed by sex (all, male, female) and for three different seasonal periods: whole (January-December), warm (April-September), and cold (October-March). Results: For female ED visits for migraine, positive associations were observed during the warm season for sulphur dioxide (SO 2 ), and in the cold season for particulate matter (PM 2.5 ) exposures lagged by 2-days. The percentage increase in daily visits was 4.0% (95% CI: 0.8-7.3) for SO 2 mean level change of 4.6 ppb, and 4.6% (95% CI: 1.2,-8.1) for PM 2.5 mean level change of 8.3 μg/m 3 . For male ED visits for headache, the largest association was obtained during the warm season for nitrogen dioxide (NO 2 ), which was 13.5% (95% CI: 6.7-20.7) for same day exposure. Conclusions: Our findings support the associations between air pollutants and the number of ED visits for headache.

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“…Epidemiological studies imply that SO 2 exposure not only induced many respiratory responses (Schwela, 2000;Herbarth et al, 2001), but linked with many neurological disorders such as migraine headaches, stroke, and brain cancer (Andersson et al, 1998;Hong et al, 2002a;Tsai et al, 2003;Szyszkowicz et al, 2009). SO 2 is a gas and exists in aqueous solution at neutral pH as an equilibrium between bisulfite and sulfite ions (NaHSO 3 and Na 2 SO 3 , 3:1 M/M), which was defined as SO 2 derivatives (Shapiro, 1977;Meng et al, 2004;Du et al, 2006).…”

Section: Introductionmentioning

confidence: 98%

SO₂inhalation modulates the expression of apoptosis-related genes in rat hippocampus via its derivativesin vivo

Yang

et al. 2010

Inhalation Toxicology

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The possible neurotoxicity of SO(2) has been implicated by determining morphological change, oxidative stress, DNA damage and membrane channel alteration in previous studies, however, its detailed mechanisms remain unclear. In the present study, we investigated SO(2) inhalation-induced effects on the transcription and translation of several apoptosis-related genes (p53, bax, bcl-2, c-fos, and c-jun) in rat hippocampus, using real-time RT-PCR analysis and western blotting technique, respectively. The results demonstrate that SO(2) statistically increased p53 expression and the ratio of bax to bcl-2 in a concentration-dependent manner. Also, mRNA and protein levels of c-fos and c-jun significantly elevated in proportion to exposure concentration. Then, we treated primary cultured hippocampal neurons with SO(2) derivatives (bisulfite and sulfite, 3:1 M/M), and examined mRNA levels of above genes. The results show that P53, c-fos, c-jun mRNA expression and the ratio of bax to bcl-2 augmented as functions of SO(2) derivative concentration and exposure time, and confirm that SO(2) affected the transcription and translation process of apoptosis-related genes in central nervous system via its derivatives in vivo. The present data provide further evidence for SO(2)-caused neurological insults, and imply that two major pathways associated with p53 and AP-1 might play important roles in the pathogenesis.

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Ambient sulphur dioxide exposure and emergency department visits for migraine in Vancouver, Canada

Cited by 34 publications

References 17 publications

The Novel Relationship between Urban Air Pollution and Epilepsy: A Time Series Study

The Novel Relationship between Urban Air Pollution and Epilepsy: A Time Series Study

Emergency department visits for migraine and headache: a multi-city study

SO₂inhalation modulates the expression of apoptosis-related genes in rat hippocampus via its derivativesin vivo

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Ambient sulphur dioxide exposure and emergency department visits for migraine in Vancouver, Canada

Cited by 34 publications

References 17 publications

The Novel Relationship between Urban Air Pollution and Epilepsy: A Time Series Study

The Novel Relationship between Urban Air Pollution and Epilepsy: A Time Series Study

Emergency department visits for migraine and headache: a multi-city study

SO2inhalation modulates the expression of apoptosis-related genes in rat hippocampus via its derivativesin vivo

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SO₂inhalation modulates the expression of apoptosis-related genes in rat hippocampus via its derivativesin vivo