Ambient Particulate Matter Concentrations and Hospitalization for Stroke in 26 Chinese Cities

Liu, Hui; Tian, Yaohua; Xu, Yan; Zhang, Jun

doi:10.1161/strokeaha.116.016482

Cited by 60 publications

(38 citation statements)

References 45 publications

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“…The 26 cites covers all the 4 municipalities (Beijing, Tianjin, Shanghai, and Chongqing), 21 of 28 provincial capital cities, and Dalian city, shown in Figure S1 . Details on the health database have been previously reported 11 , 12 . For each hospital admission, data was extracted on the date of admission, age, sex, and primary discharge diagnosis.…”

Section: Methodsmentioning

confidence: 99%

Association of short-term exposure to ambient carbon monoxide with hospital admissions in China

Liu

Tian

Xiao

et al. 2018

Sci Rep

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Evidence on the acute effects of ambient carbon monoxide (CO) pollution on morbidity risk in developing countries is scarce and inconsistent. We conducted a multicity case-crossover study in 26 largest cities in China from January, 2014 to December, 2015 to examine the association between short-term exposure to CO and daily hospital admission. We fitted conditional logistic regression to obtain effect estimates of the associations. We also performed subset analyses to explore the health effects of CO at low levels. During the study period, a total of 14,569,622, 2,008,786 and 916,388 all-cause, cardiovascular and respiratory admissions were identified, respectively. A 1 mg/m3 increase in the CO concentrations corresponded to a 3.75% (95% CI, 3.63–3.87%), 4.39% (95% CI, 4.07–4.70%), and 4.44% (95% CI, 3.97–4.92%) increase in all-cause, cardiovascular, and respiratory admissions on the same day, respectively. The associations were robust to controlling for criteria co-pollutants. In subset analyses, negative effects of short-term CO exposure on hospital admission were observed at lower concentrations (<1 mg/m3), while positive effects were observed at higher concentrations (>2 mg/m3). In conclusion, current CO levels in China were significantly associated with increased daily hospital admissions.

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Section: Methodsmentioning

confidence: 99%

Association of short-term exposure to ambient carbon monoxide with hospital admissions in China

Liu

Tian

Xiao

et al. 2018

Sci Rep

Self Cite

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“…Having thus arrived, PM 2.5 may distribute elsewhere in the body to participate in the onset of many deleterious processes, including such disparate entities as cardiovascular and metabolic diseases, neurodegenerative diseases, and lung cancer . Additionally, recent studies have demonstrated both that elevated PM 2.5 concentration increased the risk of ischemic stroke, and that it was associated with first hospital admissions for ischemic stroke …”

Section: Introductionmentioning

confidence: 99%

PM_2.5 exposure induces systemic inflammation and oxidative stress in an intracranial atherosclerosis rat model

Guan

Stone

et al. 2019

Environmental Toxicology

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Objectives: Exposure to airborne particle (PM 2.5 ) is a risk factor for intracranial atherosclerosis (ICA). Because of the established role of systemic inflammation and oxidative stress by PM 2.5 , we determined whether these processes account for PM 2.5 -mediated ICA, and also whether omega-3 fatty acid (O3FA) dietary supplementation could attenuate them.Methods: Adult Sprague-Dawley rats were exposed to filtered air (FA) or PM 2.5 and fed either a normal chow diet (NCD) or a high-cholesterol diet (HCD), administered with or without O3FA (5 mg/kg/day by gavage) for 12 weeks. The lumen and thickness of the middle cerebral artery (MCA) were assessed. Serum tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin-1β (IL-1β), and interferon gamma (IFN-γ) were detected by ELISA. Reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD) activity, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) activity, mRNA levels of Nrf2, HO-1, NQO-1, and protein level of NOX subunit gp91 were quantified to determine the oxidative profile of brain vessels.Results: PM 2.5 increased (P < .05) ICA, especially in the HCD group; elevated serum TNF-α, IL-6, IL-1β, and IFN-γ; increased cerebrovascular ROS, MDA, NOX activity, and gp91 protein levels;and decreased cerebrovascular SOD activity. Nrf2, HO-1, and NQO-1 mRNA levels were upregulated (P < .05) by PM 2.5 exposure, especially in the HCD group. O3FA attenuated (P < .05) PM 2.5 -induced systemic inflammation, vascular oxidative injury, and ICA.Conclusions: PM 2.5 exposure induced systemic inflammation, cerebrovascular oxidative injury, and ICA in rats with HCD. O3FA prevented ICA development, and may therefore exert a protective effect against the atherogenic potential of PM 2.5 . K E Y W O R D Shigh-cholesterol diet, intracranial atherosclerosis, omega-3 fatty acid, PM 2.5 , prevention

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“…In recent years, many scholars have focused on the correlation between the incidence of respiratory diseases and air pollution, which is related to the high prevalence of respiratory diseases in Hunan. The causes of air pollution are varied, including climate, geographical locations [26], industry, automobile and exhaustion, and others. Hunan is located in the central part of China.…”

Section: Discussionmentioning

confidence: 99%

Current Curative Expenditure of Respiratory Diseases and Its Influencing Factors，A Research Based on“System of Health Account 2011”

Han-hui

Wang³

et al. 2020

Preprint

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Background: Respiratory disease is now the leading cause of morbidity and mortality worldwide. They simultaneously impact public health at the population level and also cause great financial distress for families . Understanding the distribution of diseases and the Current Curative Expenditure (CCE) can provide a basis for policy decisions and interventions. This study analyzed the status of respiratory diseases spending using data from “System of Health Accounts 2011” (SHA 2011) to provide health policy advice to Hunan Province, China, and insights for other more developed areas in China. Methods: Data were collected by multi-stage stratified random sampling approach and the medical expenses of patients with respiratory diseases were calculated based on the SHA 2011, including the dimensions of institutional resource flow and service function. Regression analyses were conducted to identify influencing factors of hospitalization expenses. All analyses were conducted using software SPSS 25.0. Results: The CCE for Respiratory diseases in 2017 was 215.42 billion Chinese yuan (CNY), accounting for 15.94% of total expenditure on health in Hunan Province, China. Children aged 0-4 and elderly aged 60-69 spent the most on the treatment for such diseases. Length of stay, age, and institution level were the three most important factors affecting hospitalization expenses. Conclusions: The CCE of respiratory diseases is extremely high, with problems related to treatment efficiency and equity. It is essential to expand health insurance coverage, establish hierarchical medical system, and reduce curative expenditure.

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Ambient Particulate Matter Concentrations and Hospitalization for Stroke in 26 Chinese Cities

Abstract: This study suggests that short-term elevations in PM may increase the risk of ischemic but not hemorrhagic stroke. The associations of PM with ischemic stroke are stronger in northern China than in the south.

Cited by 60 publications

References 45 publications

Association of short-term exposure to ambient carbon monoxide with hospital admissions in China

Association of short-term exposure to ambient carbon monoxide with hospital admissions in China

PM_2.5 exposure induces systemic inflammation and oxidative stress in an intracranial atherosclerosis rat model

Current Curative Expenditure of Respiratory Diseases and Its Influencing Factors，A Research Based on“System of Health Account 2011”

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Ambient Particulate Matter Concentrations and Hospitalization for Stroke in 26 Chinese Cities

Abstract: This study suggests that short-term elevations in PM may increase the risk of ischemic but not hemorrhagic stroke. The associations of PM with ischemic stroke are stronger in northern China than in the south.

Cited by 60 publications

References 45 publications

Association of short-term exposure to ambient carbon monoxide with hospital admissions in China

Association of short-term exposure to ambient carbon monoxide with hospital admissions in China

PM2.5 exposure induces systemic inflammation and oxidative stress in an intracranial atherosclerosis rat model

Current Curative Expenditure of Respiratory Diseases and Its Influencing Factors，A Research Based on“System of Health Account 2011”

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PM_2.5 exposure induces systemic inflammation and oxidative stress in an intracranial atherosclerosis rat model