Ambient particulate matter associates with asthma in high altitude region: A population-based study

Xing, Zhenzhen; Yang, Ting; Shi, San-Qiang; Meng, Xia; Chen, Renjie; Long, Huanyu; Hu, Yanlu; Chai, Di; Liu, Weiming; Tong, Yong; Wang, Yuxia; Ma, Yali; Pan, Mingming; Chen, Jia; Sun, Tieying; Guo, Yanfei

doi:10.1016/j.waojou.2023.100774

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…In high-altitude areas, thin air, strong ultraviolet radiation, and increased human activities may have exacerbated the problem of air pollution in the environment ( 6–8 ). Studies have shown that air pollution in high-altitude regions has a significant impact on human health ( 9 , 10 ). For example, a time-series analysis revealed a correlation between air pollution and respiratory health issues in children in the Xining area ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of the interaction between cold spells and fine particulate matter on mortality risk in Xining: a case-crossover study at high altitude

Ning,

He,

Liu

et al. 2024

Front. Public Health

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BackgroundWith global climate change, the health impacts of cold spells and air pollution caused by PM2.5 are increasingly aggravated, especially in high-altitude areas, which are particularly sensitive. Exploring their interactions is crucial for public health.MethodsWe collected time-series data on meteorology, air pollution, and various causes of death in Xining. This study employed a time-stratified case-crossover design and conditional logistic regression models to explore the association between cold spells, PM2.5 exposure, and various causes of death, and to assess their interaction. We quantitatively analyzed the interaction using the relative excess odds due to interaction (REOI), attributable proportion due to interaction (AP), and synergy index (S). Moreover, we conducted stratified analyses by average altitude, sex, age, and educational level to identify potential vulnerable groups.ResultsWe found significant associations between cold spells, PM2.5, and various causes of death, with noticeable effects on respiratory disease mortality and COPD mortality. We identified significant synergistic effects (REOI>0, AP > 0, S > 1) between cold spells and PM2.5 on various causes of death, which generally weakened with a stricter definition of cold spells and longer duration. It was estimated that up to 9.56% of non-accidental deaths could be attributed to concurrent exposure to cold spells and high-level PM2.5. High-altitude areas, males, the older adults, and individuals with lower educational levels were more sensitive. The interaction mainly varied among age groups, indicating significant impacts and a synergistic action that increased mortality risk.ConclusionOur study found that in high-altitude areas, exposure to cold spells and PM2.5 significantly increased the mortality risk from specific diseases among the older adults, males, and those with lower educational levels, and there was an interaction between cold spells and PM2.5. The results underscore the importance of reducing these exposures to protect public health.

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Section: Introductionmentioning

confidence: 99%

Effects of the interaction between cold spells and fine particulate matter on mortality risk in Xining: a case-crossover study at high altitude

Ning,

He,

Liu

et al. 2024

Front. Public Health

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Tropical high altitude and severe asthma in adults: house dust mite sensitization and phenotypic distribution

Torres-Duque,

Alí-Munive,

Severiche-Bueno

et al. 2023

Journal of Asthma

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Bronchial asthma and work in high-altitude mines

Brimkulov,

Vinnikov

2023

Med. tr. prom. èkol.

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In occupational health, the management of patients with preliminary and periodic medical examinations for work in harmful conditions, for example, in high-altitude conditions, can be a difficult task. Bronchial asthma is one of the unequivocal contraindications to work in the highlands, however, in light of recent successes in achieving asthma control and the introduction of new types of therapy, this issue may require additional discussion. The article presents arguments both in favor of admitting patients with bronchial asthma to the highlands and against such a decision. The first group includes the elimination of allergens, long-term successes in the treatment of bronchial asthma in the highlands, as well as the fact that the decision not to allow it was popular in the era before the introduction of effective basic therapy for bronchial asthma with inhaled corticosteroids. The group of arguments "against" includes cold air, possible compensation only at relatively low altitudes, as well as remoteness, the inability to fully control compliance with patient requirements and the presence of typical industrial hazards in the form of allergens and irritants in production. It is particularly possible to emphasize the weakness of the evidence base, the extremely scarce number of published studies and the need for careful planning and conducting high-quality prospective observations of high-altitude mine workers, which can serve as a basis for the formation of an evidence base for adjusting admission conditions in the future. Ethics. The study did not require permission.

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Ambient particulate matter associates with asthma in high altitude region: A population-based study

Cited by 3 publications

References 38 publications

Effects of the interaction between cold spells and fine particulate matter on mortality risk in Xining: a case-crossover study at high altitude

Effects of the interaction between cold spells and fine particulate matter on mortality risk in Xining: a case-crossover study at high altitude

Tropical high altitude and severe asthma in adults: house dust mite sensitization and phenotypic distribution

Bronchial asthma and work in high-altitude mines

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