Ambient nanoparticles/nanominerals and hazardous elements from coal combustion activity: Implications on energy challenges and health hazards

Saikia, Binoy K.; Saikia, Jyotilima; Rabha, Shahadev; Silva, Luis; Finkelman, Robert B.

doi:10.1016/j.gsf.2017.11.013

Cited by 105 publications

(31 citation statements)

References 73 publications

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“…Aside from dietary sources, air pollution, which has been linked to ASD, contain many metals including naturally sourced crustal elements: Ca, Mg, Na, K, Al, Si, Fe, Ti, Mn and anthropogenically sourced metals: V, Cr, Ni, Zn, Cd, Pb, Cu 78,79 . Abnormalities in mitochondrial metabolism can be long-lasting and are implicated in a wide variety of diseases, which are suspected to have an environmental component, including psychiatric, neurodevelopmental, and neurodegenerative disorders, as well as systemic inflammation, cardiac disease, cancer, and diabetes.…”

Section: Resultsmentioning

confidence: 99%

Early life metal exposure dysregulates cellular bioenergetics in children with regressive autism spectrum disorder

et al. 2020

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Neurodevelopmental regression (NDR) is a subtype of autism spectrum disorder (ASD) that manifests as loss of previously acquired developmental milestones. Early life dysregulation of nutritional metals and/or exposure to toxic metals have been associated with ASD, but the underlying biological mechanisms by which metals influence neurodevelopment remain unclear. We hypothesize that metals influences neurodevelopment through dysregulation of bioenergetics. Prenatal and early postnatal metal exposures were measured using validated tooth-matrix biomarkers in 27 ASD cases (13 with NDR) and 7 typically-developing (TD) controls. Mitochondrial respiration and glycolysis were measured in peripheral blood mononuclear cells using the Seahorse XF96. Children with ASD demonstrated lower prenatal and postnatal Copper (Cu) and prenatal Nickel concentrations and Copper-to-Zinc (Cu/Zn) ratio as compared with TD children. Children with ASD and NDR showed greater metal-related disruption of cellular bioenergetics than children with ASD without NDR. For children with ASD and NDR mitochondrial respiration decreased as prenatal Manganese concentration increased and increased as prenatal Zinc concentration increased; glycolysis decreased with increased exposure to prenatal Manganese and Lead and postnatal Manganese. For children with ASD without a history of NDR, glycolysis increased with increased postnatal exposure to Tin. Language and communication scores in children with ASD were positively related to prenatal Cu exposure and Cu/Zn ratio. This study suggests that prenatal nutritional metals may be important for neurodevelopment in children with ASD, and that exposure to toxic metals and differences in nutritional metal exposures is associated with dysregulation of cellular bioenergetics, particularly in the NDR subtype of ASD.

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Section: Resultsmentioning

confidence: 99%

Early life metal exposure dysregulates cellular bioenergetics in children with regressive autism spectrum disorder

et al. 2020

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“…The low pH of the stomach and the presence of mucus prevent the The seemingly favorable properties of nanomaterials, as a result of their small size, can have a detrimental effect on soil and water, and thus on living organisms. In the case of uncontrolled exposure to contact with nanoparticles, they can enter the body through the digestive system, respiratory system and skin, and then accumulate in various organs [24,25]. They can also easily enter the blood through the capillaries and lymphatic endothelium, and thus enter the brain [26,27].…”

Section: Drug Carriersmentioning

confidence: 99%

Analysis of the Exposure of Organisms to the Action of Nanomaterials

et al. 2020

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The rapid development of the production of materials containing metal nanoparticles and metal oxides is a potential risk to the environment. The degree of exposure of organisms to nanoparticles increases from year to year, and its effects are not fully known. This is due to the fact that the range of nanoparticle interactions on cells, tissues and the environment requires careful analysis. It is necessary to develop methods for testing the properties of nanomaterials and the mechanisms of their impact on individual cells as well as on entire organisms. The particular need to raise public awareness of the main sources of exposure to nanoparticles should also be highlighted. This paper presents the main sources and possible routes of exposure to metal nanoparticles and metal oxides. Key elements of research on the impact of nanoparticles on organisms, that is, in vitro tests, in vivo tests and methods of detection of nanoparticles in organisms, are presented.

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“…CFA is a primary source of ultrafine and nanosized (<0.1 µm) air pollution particles that affect human and environmental health [75]. Emissions of CFA from Western power plants, unlike many in China and India, are reduced by the use of electrostatic precipitators or filters, but the collection efficiency of these technologies is lowest for ultrafine and nanoparticles [76]. The primary elements in CFA are oxides of silicon, aluminium, iron, and calcium, with lesser amounts of magnesium, sulfur, sodium, chlorine, and potassium.…”

Section: Air Pollution -Cfamentioning

confidence: 99%

Unacknowledged Potential Factors in Catastrophic Bat Die-off Arising from Coal Fly Ash Geoengineering

Herndon¹,

Whiteside

2020

AJOB

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Bats have great economic and environmental importance, including nocturnal insect control, pollination, seed dispersal and forest regeneration. Bats, however, like insects and birds are suffering a precipitous global decline due to anthropogenic causes. Deliberate air pollution in the form of undisclosed tropospheric aerosol geoengineering (TAG) has extremely damaging effects throughout the biosphere. Forensic scientific evidence implicates coal fly ash (CFA), the toxic waste product of coal-burning, as the main constituent of the jet-sprayed particulate trails seen around the world. Coal fly ash is a primary source of the ultrafine and nano-sized particulate fraction of air pollution that adversely impacts human and environmental health. Recently, countless exogenous magnetic pollution particles from combustion sources were found in human brains and heart tissue. Previous studies reveal that aerosolized CFA is a significant factor in the catastrophic global decline of birds and insects. Insects can accumulate aerosolized CFA on their body surfaces and/or ingest CFA particulates that insectivorous bats then consume. Bats are excellent mammalian bioindicators of environmental contaminants and it is known that their tissue contains high levels of metals and persistent organic pollutants. From a review of the literature, we show that the pollutant element ratios in bat tissue and bat guano are consistent with an origin in CFA-type air pollution. These findings suggest that CFA, including its use in covert climate engineering operations, is an unacknowledged factor in the morbidity and mortality of bats. Bats, therefore, are an important "canary in the coal mine" pointing to the urgency of halting covert climate engineering and greatly reducing ultrafine particulate air pollution.

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Ambient nanoparticles/nanominerals and hazardous elements from coal combustion activity: Implications on energy challenges and health hazards

Cited by 105 publications

References 73 publications

Early life metal exposure dysregulates cellular bioenergetics in children with regressive autism spectrum disorder

Early life metal exposure dysregulates cellular bioenergetics in children with regressive autism spectrum disorder

Analysis of the Exposure of Organisms to the Action of Nanomaterials

Unacknowledged Potential Factors in Catastrophic Bat Die-off Arising from Coal Fly Ash Geoengineering

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