Ambient Monitoring of Cyclophosphamide in Manufacture and Hospitals

Pyy, Lauri; Sorsa, Marja; Hakala, Erkki

doi:10.1202/0002-8894(1988)049<0314:amocim>2.0.co;2

Cited by 4 publications

(6 citation statements)

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“…In a recent study, however, no increased risks were found for miscarriages, malformations, low birth weight, or preterm birth among the offspring of nurses handling antineoplastic agents during their pregnancies /16/. In subjects between the ages of 30 From the current scientific knowledge on the mechanism of action of genotoxic carcinogens, among which almost all are alkylating antineoplastic agents, the absence of a no-adverse-effect level is supposed. Therefore, exposure to such compounds should be avoided, and safety guidelines and protective measures such as wearing masks, gloves, gowns, and special clothes, as well as the use of vertical laminar airflow safety hoods have been introduced to protect the workers when they are handling these drugs /20-22/.…”

Section: Mutagenicity Teratogenicity and Effects On Reproductionmentioning

confidence: 93%

Biomonitoring Occupational Exposure to Cytostatic Anticancer Drugs

Bos¹,

Sessink²

1997

Reviews on Environmental Health

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Cytostatic anticancer drugs are known as carcinogenic, mutagenic, and teratogenic risk factors for health care workers who are occupationally exposed during the preparation and administration of such drugs. During the last 20 years, several researchers have developed and validated methods to monitor occupational exposure to such agents. This paper reviews the literature with respect to the possible effects on occupationally exposed hospital workers and establishing occupational exposure.

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Section: Mutagenicity Teratogenicity and Effects On Reproductionmentioning

confidence: 93%

Biomonitoring Occupational Exposure to Cytostatic Anticancer Drugs

Bos¹,

Sessink²

1997

Reviews on Environmental Health

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“…Staff should be protected using safety hoods, latex gloves, surgical masks and hair cover. Detectable levels of cytotoxic agents in the air of hospital units have been observed by several groups (Pyy et al, 1988;McDevitt et al, 1993;Sessink et al, 1994). To detect the incidence of exposure, concentrations of anticancer drugs might be measured in the urine of exposed persons.…”

Section: Agentsmentioning

confidence: 98%

The effects in mice of combined treatments to X-rays and antineoplastic drugs in the Comet assay

Dobrzyńska

2005

Toxicology

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“…Consequently, the handling of these drugs by hospital personnel involved in their preparation and administration is referred to as an occupational health hazard. [4][5][6][7][8][9][10] Moreover, since it is difficult to set a safe level, even very low exposures should be avoided.…”

mentioning

confidence: 99%

Application of high performance liquid chromatography/tandem mass spectrometry in the environmental and biological monitoring of health care personnel occupationally exposed to cyclophosphamide and ifosfamide

Minoia

Turci

Sottani

et al. 1998

Rapid Commun. Mass Spectrom.

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Twenty four workers (10 involved in the preparation and 14 in administration) exposed to cyclophosphamide (CP) and ifosfamide (IF) in two Italian hospitals were monitored. The extent of exposure was assessed by the analysis of air samples, wipe samples, pads and gloves. Urinary excretion at the beginning and at the end of the work shift was also measured by liquid-liquid extraction and analysis by high performance liquid chromatography/tandem mass spectrometry. Three out of 24 air samples were positive for CP or IF. In wipe samples, CP concentrations ranging from < 0.001 to 82.4 micrograms/dm2 in Hospital A (32 samples) and from 0.2 to 383.3 micrograms/dm2 in Hospital B (17 samples), were found. IF concentrations varied from < 0.001 to 90.9 micrograms/dm2 in Hospital A and from 0.01 to 141.5 micrograms/dm2 in Hospital B. Pads (from 11 to 13 for each operator) were contaminated with CP and IF especially on arms, legs and chest. The use of a plastic-backed liner on the working tray in the laminar flow hoods was demonstrated to compromise the containment properties of the hood. Urine samples were positive for CP in 50% of the workers (range: 0.1-2.1 micrograms/L), whereas IF was detected in 2 subjects only (range: 0.1-0.8 microgram/L). The results of this investigation demonstrate that vertical laminar airflow hoods, when incorrectly used, might represent a source of contamination and that higher risk may depend on lack of educational programmes and observance of preventive guidelines.

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Ambient Monitoring of Cyclophosphamide in Manufacture and Hospitals

Cited by 4 publications

References 0 publications

Biomonitoring Occupational Exposure to Cytostatic Anticancer Drugs

Biomonitoring Occupational Exposure to Cytostatic Anticancer Drugs

The effects in mice of combined treatments to X-rays and antineoplastic drugs in the Comet assay

Application of high performance liquid chromatography/tandem mass spectrometry in the environmental and biological monitoring of health care personnel occupationally exposed to cyclophosphamide and ifosfamide

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