Ambient hydrogen sulfide exposure increases the severity of influenza A virus infection in swine

Santana, Cristina Mahugo; Gauger, Phillip C.; Vetger, Amber; Magstadt, Drew R.; Kim, Dong-Suk; Shrestha, Denusha; Charavaryamath, Chandrashekhar; Rumbeiha, Wilson K.

doi:10.1080/19338244.2021.1896986

Cited by 5 publications

(2 citation statements)

References 45 publications

(51 reference statements)

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“…In Figure 10D , it is of interest to see that ASVs assigned to the family Desulfovibrionaceae are found to act as kinless hubs. Although Desulfovibrionaceae was not found as a dominant family in our analysis at day 21, it is known to produce hydrogen sulfide ( H 2 S ), higher concentration of which is reported to increase the seriousness of IAV infection (Santana et al, 2021 ), while a reduced amount of H 2 S is found to protect against the viral infection (Dilek et al, 2020 ).…”

Section: Resultsmentioning

confidence: 91%

Application of a maximal-clique based community detection algorithm to gut microbiome data reveals driver microbes during influenza A virus infection

et al. 2022

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Influenza A Virus (IAV) infection followed by bacterial pneumonia often leads to hospitalization and death in individuals from high risk groups. Following infection, IAV triggers the process of viral RNA replication which in turn disrupts healthy gut microbial community, while the gut microbiota plays an instrumental role in protecting the host by evolving colonization resistance. Although the underlying mechanisms of IAV infection have been unraveled, the underlying complex mechanisms evolved by gut microbiota in order to induce host immune response following IAV infection remain evasive. In this work, we developed a novel Maximal-Clique based Community Detection algorithm for Weighted undirected Networks (MCCD-WN) and compared its performance with other existing algorithms using three sets of benchmark networks. Moreover, we applied our algorithm to gut microbiome data derived from fecal samples of both healthy and IAV-infected pigs over a sequence of time-points. The results we obtained from the real-life IAV dataset unveil the role of the microbial families Ruminococcaceae, Lachnospiraceae, Spirochaetaceae and Prevotellaceae in the gut microbiome of the IAV-infected cohort. Furthermore, the additional integration of metaproteomic data enabled not only the identification of microbial biomarkers, but also the elucidation of their functional roles in protecting the host following IAV infection. Our network analysis reveals a fast recovery of the infected cohort after the second IAV infection and provides insights into crucial roles of Desulfovibrionaceae and Lactobacillaceae families in combating Influenza A Virus infection. Source code of the community detection algorithm can be downloaded from https://github.com/AniBhar84/MCCD-WN.

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Section: Resultsmentioning

confidence: 91%

Application of a maximal-clique based community detection algorithm to gut microbiome data reveals driver microbes during influenza A virus infection

et al. 2022

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“…We postulated that metabolic signatures of acute H2S poisoning were different from those following subchronic exposure to low level ambient H2S as clinical presentations are different [3,[5][6][7][8][9]12,13,20]. We therefore conducted this study to understand brain metabolomic changes induced by a single acute exposure to a high concentration of H2S and that caused by subchronic exposure to ambient concentration of H2S.…”

Section: Introductionmentioning

confidence: 99%

Metabolomic Signatures of Brainstem in Mice following Acute and Chronic Hydrogen Sulfide Exposure

Kim,

Maldonado,

Giulivi

et al. 2023

Preprint

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Hydrogen sulfide (H2S) is an environmental toxicant of health concern. The brain is a major target in acute H2S poisoning. This study was to test the hypothesis that acute and subchronic ambient H2S exposures alter the brain metabolome. Male 7-8 week-old C57BL/6J mice were exposed by whole-body inhalation to 1000 ppm H2S for 45 min and euthanized at 5 min or 72 h for acute exposure. For subchronic study, mice were exposed to 5 ppm H2S 2 h/day, 5 days/week for 5 weeks. The brainstem was removed for metabolomic analysis. Enrichment analysis showed the metabolomic profiles in acute and subchronic H2S exposures matched with those of cerebral spinal fluid from patients with seizures or Alzheimer’s disease. Acute H2S exposure decreased excitatory neurotransmitters, aspartate and glutamate, while the inhibitory neurotransmitter, serotonin, was increased, which may explain H2S-induced loss of consciousness. Branched-chain amino acids and glucose were increased by acute H2S exposure. Subchronic H2S exposure within OSHA guideline surprisingly decreased serotonin altering central nervous system. In subchronic H2S exposure, glucose was decreased while polyunsaturated fatty acids, inosine, and hypoxanthine were increased. Collectively, these results provide important mechanistic clues of acute and subchronic ambient H2S poisonings and show that H2S alters brainstem metabolome.

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Cost Oriented Cyber-Physical System algorithm for pig farm microclimate and air quality control

Dimitrov

Chivarov

2022

IFAC-PapersOnLine

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Ambient hydrogen sulfide exposure increases the severity of influenza A virus infection in swine

Cited by 5 publications

References 45 publications

Application of a maximal-clique based community detection algorithm to gut microbiome data reveals driver microbes during influenza A virus infection

Application of a maximal-clique based community detection algorithm to gut microbiome data reveals driver microbes during influenza A virus infection

Metabolomic Signatures of Brainstem in Mice following Acute and Chronic Hydrogen Sulfide Exposure

Cost Oriented Cyber-Physical System algorithm for pig farm microclimate and air quality control

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