Ambient exposure and nasal inflammation in adults and children – a preliminary analysis

Polat, Dünya; Eberwein, Georg; Becker, A.; Weishaupt, Christel; Schins, Roel P.F.; Ranft, Ulrich; Borm, Paul

doi:10.1078/1438-4639-00122

Cited by 5 publications

(9 citation statements)

References 19 publications

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“…However, for NW to be a useful clinical tool it will need to be performed with the child conscious. NW has been demonstrated to have acceptable reproducibility 20 and has been used in older children and adults to study the effects of air pollution 19 . Polat et al 19 .…”

Section: Discussionmentioning

confidence: 99%

“…NW has been demonstrated to have acceptable reproducibility 20 and has been used in older children and adults to study the effects of air pollution. 19 Polat et al 19 performed NW in 501 mothers and 383 children, aged 6-7 years, and reported success rates of 90% and 75%, respectively. NW has also been used successfully to measure nasal inflammatory profiles in infants with acute bronchiolitis.…”

Section: Discussionmentioning

confidence: 99%

“…[10][11][12][13][14][15][16][17] Previous studies have shown that nasal samples may reflect lung inflammation in infants with bronchiolitis, 11,[16][17][18] and have been used to study environmental exposures. 19,20 However, in children with CF and established lung disease, cytokines and cells from nasal secretions did not show a significant correlation with lung samples. 21 The massive lower airway bacterial infection in these patients may explain this lack of correlation.…”

Section: Introductionmentioning

confidence: 90%

“…The use of the nose to assess airway inflammation has been studied in upper and lower respiratory diseases in children 10–17 . Previous studies have shown that nasal samples may reflect lung inflammation in infants with bronchiolitis, 11,16–18 and have been used to study environmental exposures 19,20 . However, in children with CF and established lung disease, cytokines and cells from nasal secretions did not show a significant correlation with lung samples 21 .…”

Section: Introductionmentioning

confidence: 99%

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Nasal wash as an alternative to bronchoalveolar lavage in detecting early pulmonary inflammation in children with cystic fibrosis

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nasal wash as an alternative to bronchoalveolar lavage in detecting early pulmonary inflammation in children with cystic fibrosis

et al. 2005

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“…393 Therefore, in addition to O 3 , it appears that particles are able to induce a proinflammatory response in nasal lavage samples. However, exposures to NO 2 , 394 ambient pollutants across different cities, 395 VOCs, 396 or SO 2 397 have had no influence on measured biomarkers in NLF.…”

Section: Biomarkersmentioning

confidence: 92%

Noninvasive effects measurements for air pollution human studies: methods, analysis, and implications

Mirowsky

Gordon

2015

J Expo Sci Environ Epidemiol

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Human exposure studies, compared with cell and animal models, are heavily relied upon to study the associations between health effects in humans and air pollutant inhalation. Human studies vary in exposure methodology, with some work conducted in controlled settings, whereas other studies are conducted in ambient environments. Human studies can also vary in the health metrics explored, as there exists a myriad of health effect end points commonly measured. In this review, we compiled mini reviews of the most commonly used noninvasive health effect end points that are suitable for panel studies of air pollution, broken into cardiovascular end points, respiratory end points, and biomarkers of effect from biological specimens. Pertinent information regarding each health end point and the suggested methods for mobile collection in the field are assessed. In addition, the clinical implications for each health end point are summarized, along with the factors identified that can modify each measurement. Finally, the important research findings regarding each health end point and air pollutant exposures were reviewed. It appeared that most of the adverse health effects end points explored were found to positively correlate with pollutant levels, although differences in study design, pollutants measured, and study population were found to influence the magnitude of these effects. Thus, this review is intended to act as a guide for researchers interested in conducting human exposure studies of air pollutants while in the field, although there can be a wider application for using these end points in many epidemiological study designs.

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Hydroxyl-radical-dependent DNA damage by ambient particulate matter from contrasting sampling locations

Shi¹,

Duffin²,

Borm³

et al. 2006

Environmental Research

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Ambient exposure and nasal inflammation in adults and children – a preliminary analysis

Cited by 5 publications

References 19 publications

Nasal wash as an alternative to bronchoalveolar lavage in detecting early pulmonary inflammation in children with cystic fibrosis

Nasal wash as an alternative to bronchoalveolar lavage in detecting early pulmonary inflammation in children with cystic fibrosis

Noninvasive effects measurements for air pollution human studies: methods, analysis, and implications

Hydroxyl-radical-dependent DNA damage by ambient particulate matter from contrasting sampling locations

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