“…Another investigation has indicated a great deal of uncertainty in projecting reductions in CO concentrations needed to meet the air quality standards. 6 However, calculations of required pollutant reductions in 5 cities based upon annual mean CO concentrations rather than the second highest 8 hr average measurement resulted in a good correlation between the calculated necessary reduction and the median COHb levels in the population, as shown in Tables I and II. Use of annual averages rather than highest measured values may be more meaningful for evaluating population exposures to CO because missing data, instrument malfunctions and possible anomalous occurrences would not tend to be as significant in an annual average.…”