Ambient Air Pollution and the Risk of Central Retinal Artery Occlusion

Cheng, Hui‐Chen; Pan, Ren-Hao; Yeh, Huan-Jui; Lai, K. Robert; Yen, May-Yung; Chan, Chien-Lung; Wang, An-Guor

doi:10.1016/j.ophtha.2016.08.046

Cited by 25 publications

(27 citation statements)

References 37 publications

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“…The risk of central retinal artery occlusion (CRAO) onset significantly increased during a period less than 1 week, following a 1 PPM increase in NO 2 levels. However, particulate matter and O 3 did not show significance in this study which was conducted in Taiwan (Cheng et al, 2016). Besides CRAO, components of air pollutants lead to central retinal vein occlusion (CRVO) as well.…”

Section: Retinal Vessels Narrowing and Occlusion Gaseous And Pmmentioning

confidence: 54%

Impact on Eye Health Regarding Gaseous and Particulate Pollutants

Chang

Yang

2020

Aerosol Air Qual. Res.

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Air pollutants are a mixture of thousands of compounds, including ozone (O 3), carbon monoxide (CO), sulfur dioxide (SO 2), nitrogen oxides (NO x), volatile organic compounds (VOCs), and particulate matter (PM), all of which are considered to be the most significant compounds from a health provider's viewpoint. The association between air pollutants and human health has been investigated for many decades. These adverse health effects on mankind include acute and chronic impacts. Nearly all the systems of the human body can be affected. There had been substantial evidence pointing out that air pollutants are able to cause serious consequences in human's respiratory and neurological health system (Mannucci et al., 2015; Mannucci and Franchini, 2017; Chen et al., 2020). The retinal tissue and optic nerve are regarded as part of the central nervous system (CNS), because their development are protuberances of an embryological brain (Sebastian, 2010). However, the eyes are often a neglected organ in the area of environmental medicine. Most people anticipate air pollutants' health impacts on the eyes are limited to the eye surface, and simple eye irritation; in fact, air pollutants have a much greater impact on the eyes than we think. In this article, the authors reviewed all the acute and chronic health effects of gaseous and particulate air pollutants on the eyes to highlight the complexity of the relationship of air pollutants and eye health. ACUTE IMPACTS Ocular Surface Disorders Gaseous and PM It's well known air pollutants can lead to significant eye irritation and discomfort due to their having direct contact with the ocular surface. People who exposed to higher level of air pollutants were supposed to have significantly worse performance in tear break-up time (TBT) and Schirmer's test. Approximate a half of these air pollutants exposed people complained of both eye redness and irritation, compared to one fifth in less exposed ones (Saxena et al., 2003). The subjective ocular surface symptoms, as well as those of respiratory tract, were not compatible with the objective test values. Sometimes, air pollutants caused more severe symptoms than test measurements, especially for certain gaseous pollutants

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Section: Retinal Vessels Narrowing and Occlusion Gaseous And Pmmentioning

confidence: 54%

Impact on Eye Health Regarding Gaseous and Particulate Pollutants

Chang

Yang

2020

Aerosol Air Qual. Res.

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“…The results of our study and Cheng et al were consistent regarding exposure to SO 2 and NO 2 . Cheng et al investigated the risk of CRAO caused by changes in the ambient air pollution [5]. In his study, 96 newly diagnosed CRAO onset patients that were randomly selected from the Taiwan National Health Insurance Research Database were examined.…”

Section: Discussionmentioning

confidence: 99%

“…Chen et al suggested that effects of PM 2.5 on cardiovascular diseases may be related to acute effects on cytokine expression, which may be partly mediated through effects of PM 2.5 on miRNAs that regulate cytokine expression [13]. Other mechanisms regarding vasoconstriction and hypercoagulability have also been suggested in the literature [5,14,15].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the Association between the Risk of Central Retinal Artery Occlusion and the Concentration of Environmental Air Pollutants

Grzybowski

Mimier

2019

JCM

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The purpose of the retrospective, population-based study was to assess the relationship between the risk of central retinal artery occlusion (CRAO) and the level of air pollutants. This study identified 2.272 cases of newly diagnosed CRAO registered in the Polish National Health Service database. The study authors gathered hourly ambient concentrations of particulate matter—PM 2.5, PM 10, benzene, carbon monoxide, nitrogen dioxide, ozone, and sulfur dioxide from pollution monitoring stations. Data on average daily temperature and atmospheric pressure were also obtained. In the statistical analyses, single- and multi-factor Poisson negative binomial regression models were carried out, controlling also for ambient temperature and atmospheric pressure with seasonality set at a level of 4. This study has shown a positive association between CRAO onset and short-term, daily changes in PM 10, NO2, SO2, O3, and CO concentrations, as well as with air temperature, in the days preceding the diagnosis.

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“…Fungal keratitis is more common in certain geographic areas with hotter weather. A hot environment may then potentially worsen the burden of trachoma and may trigger the formation of cataracts and the occurrence of central retinal artery occlusion (CRAO) [18,22,23].…”

Section: Thermal Damagementioning

confidence: 99%