Ambient air pollution and hospitalization for type 2 diabetes in China: A nationwide, individual-level case-crossover study

Luo, Hao; Liu, Cong; Chen, Xiyin; Lei, Jian; Zhu, Yixiang; Zhou, Lu; Gao, Ya; Meng, Xia; Kan, Haidong; Xuan, Jianwei; Chen, Renjie

doi:10.1016/j.envres.2022.114596

Cited by 10 publications

(16 citation statements)

References 35 publications

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“…Different pronounced effects in cold and warm seasons may be owing to various characteristic of air pollution, climate conditions and pollutant sources. Previous studies have found stronger association between air pollution and T2DM HAs in cold season (Luo et al., 2023). With less rain and wind during cold season, the higher levels of particle pollutants are associated with slower diffusion.…”

Section: Discussionmentioning

confidence: 78%

The Short‐Term Effects and Burden of Ambient Air Pollution on Hospitalization for Type 2 Diabetes: Time‐Stratified Case‐Crossover Evidence From Sichuan, China

Jiang,

Chen,

et al. 2023

GeoHealth

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Type 2 diabetes mellitus (T2DM), a complicated metabolic disease, might be developed or exacerbated by air pollution, resulting in economic and health burden to patients. So far, limited studies have estimated associations between short‐term exposure to air pollution and disease burden of T2DM in China. Hence, we aimed to estimate the associations and burden of ambient air pollutants (NO2, PM10, PM2.5, SO2, and CO) on hospital admissions (HAs) for T2DM using a time‐stratified case‐crossover design. Data on HAs for T2DM during 2017–2019 were collected from hospital electronic health records in nine cities in Sichuan Province using conditional poisson regression. Totally, 92,381 T2DM hospitalizations were recorded. There were significant short‐term effects of NO2, PM10, PM2.5, SO2 and CO on HAs for T2DM. A 10 μg/m3 increment of NO2, PM10, PM2.5, SO2 and CO as linked with a 3.39% (95% CI: 2.26%, 4.54%), 0.33% (95% CI: 0.04%, 0.62%), 0.76% (95% CI: 0.35%, 1.16%), 12.68% (95% CI: 8.14%, 17.42%) and 79.00% (95% CI: 39.81%, 129.18%) increase in HAs for T2DM at lag 6. Stratified analyses modified by age, sex, and season showed old (≥65 years) and female patients linked with higher impacts. Using WHO's air quality guidelines of NO2, PM10, PM2.5, and CO as the reference, the attributable number of T2DM HAs exceeding these pollutants exposures were 786, 323, 793, and 2,127 during 2017–2019. Besides, the total medical costs of 25.83, 10.54, 30.74, and 67.78 million China Yuan were attributed to NO2, PM10, PM2.5, and CO. In conclusion, short‐term exposures to air pollutants were associated with higher risks of HAs for T2DM.

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Section: Discussionmentioning

confidence: 78%

The Short‐Term Effects and Burden of Ambient Air Pollution on Hospitalization for Type 2 Diabetes: Time‐Stratified Case‐Crossover Evidence From Sichuan, China

Jiang,

Chen,

et al. 2023

GeoHealth

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“…We obtained daily hospitalization events from the SuValue database, details of which have been described elsewhere. , In brief, this database links hospitals across 20 provincial-level regions in China and generates a structured patient-level database after extracting, validating, and aggregating medical records directly from the hospital information system. In this analysis, we extracted hospitalization data for cardiovascular diseases from 153 hospitals in the SuValue database during the study period from 2013 to 2020 (Figure S1).…”

Section: Methodsmentioning

confidence: 99%

Ambient Nitrogen Dioxide and Hospitalizations of Full-Spectrum Respiratory Diseases: A National Case-Crossover Study

et al. 2023

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Few multicity studies have examined the acute effects of nitrogen dioxide (NO 2 ) on respiratory disease (RD), especially its specific causes. This study aimed to investigate the associations between short-term exposure to NO 2 and hospitalization of full-spectrum RDs in China. Hospitalization of 10 major categories and 40 cause-specific RDs were obtained from 20 provinces over the study period of 2013−2020. A time-stratified case-crossover study was conducted at the individual level to explore the associations between NO 2 and RDs. NO 2 was significantly associated with increased hospitalization of eight major RDs (acute upper respiratory infections, influenza and pneumonia, acute lower respiratory infections, upper respiratory tract diseases, chronic lower respiratory diseases, respiratory interstitium diseases, pleura diseases, and other respiratory diseases) and 18 specific causes of RDs, with the largest associations observed on lag 0−1 day. The effect estimates ranged from 0.75 to 4.09% per 10 μg/m 3 of NO 2 exposure. The associations remained robust after controlling for copollutants. The concentration−response curves were mostly positive and linear. This nationwide study provides comprehensive information on the acute effects of NO 2 on respiratory morbidity across the full spectrum, highlighting the need for caution with regard to this important traffic-related air pollutant in current pollution control programs.

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“…Although extensive evidence has investigated the associations between ambient air pollution and T2DM-related outcomes, [16][17][18][19][20][21][22] there are still some gaps in our understanding. First, the majority of prior studies have assessed the correlations between long-term air pollution exposure and the prevalence and incidence of T2DM.…”

Section: Introductionmentioning

confidence: 99%

“…First, the majority of prior studies have assessed the correlations between long-term air pollution exposure and the prevalence and incidence of T2DM. 23,24 Few investigations have been performed on the relationship between short-term exposures and T2DM morbidity risk, [16][17][18]22 although short-term exposure to air pollution has been demonstrated to potentially lead to metabolic disruption. 23,24 Second, the results regarding the associations between short-term exposure to air pollution and T2DM morbidity risk were inconclusive.…”

Section: Introductionmentioning

confidence: 99%

“…25 However, a separate research study conducted in Chengdu did not discover such associations. 26 Third, the data in prior studies have largely focused on hospitalization, 16,18,22 and few researchers have paid attention to daily outpatient visits. Compared to hospitalization, it is more advantageous to use daily outpatient visits than hospitalizations when studying the effects of short-term exposure to pollutants on diseases because hospitalization numbers always tend to be saturated.…”

Section: Introductionmentioning

confidence: 99%

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Association between short-term ambient air pollutants and type 2 diabetes outpatient visits: a time series study in Lanzhou, China

Ye,

Ma,

Dong

et al. 2024

Environ. Sci.: Processes Impacts

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Ambient air pollution and hospitalization for type 2 diabetes in China: A nationwide, individual-level case-crossover study

Cited by 10 publications

References 35 publications

The Short‐Term Effects and Burden of Ambient Air Pollution on Hospitalization for Type 2 Diabetes: Time‐Stratified Case‐Crossover Evidence From Sichuan, China

The Short‐Term Effects and Burden of Ambient Air Pollution on Hospitalization for Type 2 Diabetes: Time‐Stratified Case‐Crossover Evidence From Sichuan, China

Ambient Nitrogen Dioxide and Hospitalizations of Full-Spectrum Respiratory Diseases: A National Case-Crossover Study

Association between short-term ambient air pollutants and type 2 diabetes outpatient visits: a time series study in Lanzhou, China

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