Ambience and Drug Choice: Cocaine- and Heroin-Taking as a Function of Environmental Context in Humans and Rats

Caprioli, Daniele; Celentano, Michele; Dubla, Alessandro; Lucantonio, Federica; Nencini, Paolo; Badiani, Aldo

doi:10.1016/j.biopsych.2008.12.009

Cited by 81 publications

(72 citation statements)

References 37 publications

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“…For instance, the sedative effects of heroin are hypothesized to be evaluated more negatively in an unfamiliar setting than at home which would explain why heroin is less rewarding outside the home setting (Caprioli et al, 2008). More generally, this setting-dependent evaluation would explain why most individuals prefer using certain drugs in a given setting (eg, heroin is preferred over cocaine at home) (Caprioli et al, 2009) and why they prefer certain settings to use a given drug (eg, home is preferred for using heroin) (Caprioli et al, 2007(Caprioli et al, , 2008. Whether this settingdependent evaluation can be generalized to all nonhedonic effects of cocaine and heroin, in particular to their orexigenic or anorexigenic effects that are the focus of this study, is not clear at present and deserve additional research (Paolone et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Choosing Under the Influence: A Drug-Specific Mechanism by Which the Setting Controls Drug Choices in Rats

Vandaele

Cantin

Serre

et al. 2015

Neuropsychopharmacol

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Ample evidence shows that the setting can control drug choices in both humans and animals. Here we reveal in rats that a major mechanism of this control involves a regulation of the drug influence on other competing options at the time of choice. Briefly, rats were offered a choice between a drug dose (cocaine or heroin) and a brief access to water sweetened with saccharin in two different settings. In one setting, choosing under the influence was not possible and rats largely preferred saccharin over either cocaine or heroin. In contrast, when the same rats were shifted to a setting where choosing under the influence was possible, they chose the drug either nonexclusively or exclusively depending on whether the drug enhanced or suppressed sweet reward, respectively. Thus, when rats were under the orexigenic influence of heroin at the time of choice, they more frequently chose saccharin in alternation with heroin. In contrast, when rats were under the anorexic influence of cocaine, they stopped choosing saccharin and continued taking cocaine exclusively. These settingand drug-specific changes in preference were rapid and reversible, and could be induced by passively administering cocaine or heroin before choice. Finally, rats behaved as if they were oblivious to the drug influence on their choices. This behavior could explain why rats are vulnerable to harm themselves, sometimes to the point of death, in settings where choices are made under the drug influence, notably if this influence excludes other important options or, conversely, enhances harmful ones.

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Section: Discussionmentioning

confidence: 99%

Choosing Under the Influence: A Drug-Specific Mechanism by Which the Setting Controls Drug Choices in Rats

Vandaele

Cantin

Serre

et al. 2015

Neuropsychopharmacol

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“…Currently, there is rising interest in comparing directly the results obtained from home cage testing versus the conventional Skinner box setting. Furthermore, the two kinds of setting will not necessarily lead to identical results: As underlined by a very recent report (Caprioli et al, 2009), comparing the performance of animals in their home cage versus a different testing apparatus may open avenues for very innovative findings.…”

Section: Discussionmentioning

confidence: 99%

Home cage testing of delay discounting in rats

Koot

Adriani

Saso

et al. 2009

Behavior Research Methods

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Testing rodents in their home cages has become increasingly popular. Since human intervention, handling, and transport are minimized, behavior can be recorded undisturbed and continuously. Currently existing home cage systems are too complex if only relatively simple operant-learning tests are to be carried out in rats. For that purpose, a new low-cost computer-controlled operant panel was designed, which can be placed inside the home cage. A pilot study was carried out, using an intolerance-to-delay protocol, classically developed for testing behavioral impulsivity. Male adult rats were tested in their home cages, containing the operant panel provided with nose-poking holes. Nose poking in one hole resulted in the immediate delivery of one food pellet (small-soon, SS), whereas nose poking in the other hole delivered five food pellets after a delay (large-late), which was increased progressively each day (0-150 sec). The two daily sessions, spaced 8 h apart, lasted 1 h each, and the time-out after food delivery was 90 sec. A clear-cut shift toward preference for SS, which is considered a classical index of cognitive impulsivity, was shown at the longest delay. It is noteworthy that rats shifted when the delay interval was longer than the mean intertrial interval-that is, when they experienced more than one delay-equivalent odds against discounting (see Adriani & Laviola, 2006). The shortened training (2 days) and testing (5 days) phases, as allowed by prolonged and multiple daily sessions, can be advantageous in testing rodents during selected short phases of development. Current research is focusing on further validation of this and similar protocols

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“…These findings are reported here for the first time. The experimental procedures were similar to those described by Caprioli et al (2009). Briefly, 14 male Sprague-Dawley rats (Harlan, Italy), weighing 250 -275 g at their arrival, were housed and tested in the same dedicated temperature and humidity-controlled rooms, with free access (except during the test sessions) to food and water under a 14-h dark/10-h light cycle (lights off at 7:00 am).…”

Section: Setting Of Ketamine Use: Pre-clinical Studiesmentioning

confidence: 99%

The role of setting for ketamine abuse: clinical and preclinical evidence

Luca¹,

Meringolo²,

Spagnolo³

et al. 2012

Reviews in the Neurosciences

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(2012) The role of setting for ketamine abuse: clinical and preclinical evidence. Reviews in the neurosciences, 23 (5-6). pp. 769-780. ISSN 0334-1763 This version is available from Sussex Research Online: http://sro.sussex.ac.uk/57391/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. The role of setting for ketamine abuse: clinical and preclinical evidence Abstract: Drug abuse is often seen as a unitary phenomenon, partly as a result of the discovery over the past three decades of shared mechanisms of action for addictive substances. Yet the pattern of drug taking is often very different from drug to drug. This is particularly evident in the case of ' club drugs ' , such as ketamine. Although the number of ketamine abusers is relatively small in the general population, it is quite substantial in some settings. In particular, ketamine abuse is almost exclusively limited to clubs and large music parties, which suggests a major role of context in modulating the reward effects of this drug. This review focuses on recent preclinical and clinical findings, including previously unpublished data, that provide evidence that, even under controlled conditions, ketamine reward is a function of the setting of drug taking.

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Ambience and Drug Choice: Cocaine- and Heroin-Taking as a Function of Environmental Context in Humans and Rats

Cited by 81 publications

References 37 publications

Choosing Under the Influence: A Drug-Specific Mechanism by Which the Setting Controls Drug Choices in Rats

Choosing Under the Influence: A Drug-Specific Mechanism by Which the Setting Controls Drug Choices in Rats

Home cage testing of delay discounting in rats

The role of setting for ketamine abuse: clinical and preclinical evidence

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