Amazonian Brazilian medicinal plants described by C.F.P. von Martius in the 19th century

Breitbach, Ulrike B.; Niehues, Michael; Lopes, Norberto Peporine; Faria, Jair Eustáquio Quintino; Brandão, Maria G.L.

doi:10.1016/j.jep.2013.02.030

Cited by 74 publications

(38 citation statements)

References 50 publications

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“…In the Brazilian Amazon, distinct species are used to heal wounds or leishmaniasis. Among these stand out: Montrichardia linifera (Arruda) Schott [4], Himatanthus articulates (Vahl) Woodson [5,6] and Parahancornia fasciculata (Poir.) Benoist [7].…”

Section: Leishmaniasis Is Caused By the Protozoanmentioning

confidence: 99%

Anti-promastigote Activity of the Amazon Plants

Silva-Silva¹,

Monteiro²,

Brígido³

et al. 2017

JPP

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This study evaluated in vitro activity of ethanol extract, fractions, and isolated substance from Amazon species against promastigotes of L. amazonensis. The ethanol extracts were concentrated and fractionation. The anti-promastigote activity was evaluated through the cell viability assessment method (MTT). The ethanol extract, fractions, and isolated substance from Himatanthus articulatus and Parahancornia fasciculata were inactive in promastigote of L. amazonensis, as the ethanol extract of Physalis angulata. The hexane fractions from different parts of Montrichardia linifera showed anti-promastigote activity probably due to the presence of steroids and terpenes. All species in studies were inactive, except of M. linifera. The few polar constituents can be responsible for the activity. Therefore, the isolation and purification of the active on L. amazonensis promastigotes are urgently required.

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Section: Leishmaniasis Is Caused By the Protozoanmentioning

confidence: 99%

Anti-promastigote Activity of the Amazon Plants

Silva-Silva¹,

Monteiro²,

Brígido³

et al. 2017

JPP

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“…Brazil has also a long tradition in the study of its biodiversity, although during three centuries, from the first colonizers in 1500 to the arrival in Brazil of the Portuguese Royal family in 1808, description, except for the brief period during Dutch and French occupation of small parts of the territory, was almost limited to the Portuguese colonizers themselves. 58,62,63,[192][193][194][195][196][197][198] The second reason is its huge biodiversity and the third is the technical and scientific capacity of the research community, I have discussed the first two elsewhere. 58 …”

Section: -95mentioning

confidence: 99%

Research with Chemistry and Pharmacology of Natural Products in Brazil: A Comparison with 70 Selected Countries from 5 Continents

Alves¹,

Pontes²

2017

Rev. Virtual Quim.

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Living organisms (bacteria, fungi, lichens, algae, worms, mushrooms, higher plants, and aquatic and terrestrial animals) produce a plethora of chemical compounds, the natural products , that lie at the heart of an ecological interaction, acting as molecular messengers in defense, attack, sexual attraction, territorial and trail marking, in pollination, as venoms, etc. Eventually, human beings make use of them for their own purposes as food additives, flavoring, cosmetics, fragrances, hallucinogens, in pest control, and as therapeutic agents. The present review compares the participation of Brazilian scientists in the chemistry and pharmacology of natural products with that of other scientists from 69 countries in five continents in 36 selected journals. It also shows the analogy between the Human Development Index (HDI) and the rank of the countries with the number published articles. The search was performed in the Web of Knowledge by cross-selecting the names of each journal with that of each country for the period 1945-2013.Keywords: Brazil; chemistry of natural products; pharmacology of natural products; peer journals. ResumoOrganismos vivos (bactérias, fungos, liquens, vermes, cogumelos, vegetais superiores, e animais aquáticos e terrestres) produzem uma pletora de substâncias químicas, os produtos naturais , que estão no coração de uma interação ecológica, atuando como mensageiros moleculares na defesa, ataque, atração sexual, marcação territorial e de trilha, na polinização, como venenos, etc. Eventualmente, os seres humanos fazem uso deles para o seu próprio benefício como aditivos, flavorizantes, cosméticos, fragrância, alucinógenos, no controle de pestes, e como agentes terapêuticos. Esta revisão compara a participação de cientistas brasileiros na química e farmacologia de produtos naturais com a de cientistas de 69 países de cinco continentes em 36 periódicos selecionados. Ela também mostra a analogia entre o Índice de Desenvolvimento Humano (IDH) e a classificação dos países com o número de artigos publicados. A pesquisa foi realizada na Web of Knowledge através de seleção cruzada do nome de cada periódico com o de cada país no período 1945-2013.Palavras-chave: Brasil; química de produtos naturais; farmacologia de produtos naturais; periódicos.

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“…From 580 g of S. systila leaves, 18.8 g of CH 2 Cl 2 extract and 65 g of MeOH extract were obtained. The MeOH (5 g) extract of O. puncticulosa was fractionated using MPLC with a C 18 60 …”

Section: Preparation Of the Crude Extractsmentioning

confidence: 99%

“…17 O. puncticulosa has been traditionally used in South America to treat rubeola, digestive disorders and side effects caused by snakebite. [18][19][20] Only O. macrantha has been chemically studied with the identification of a new cytotoxic limonoid and two triterpenoids. 21 The Conostegia genus (Melastomataceae) contains 42 species and none of these species have been investigated from a phytochemical viewpoint.…”

Section: Introductionmentioning

confidence: 99%

Identification of Triterpenoids from Schefflera systyla, Odontadenia puncticulosa and Conostegia speciosa and In Depth Investigation of Their in vitro and in vivo Antifungal Activities

Favre-Godal¹,

Dorsaz²,

Marcourt³

et al. 2016

J. Braz. Chem. Soc.

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As a part of a broad screening of antifungal agents from plant origin, crude extracts from Panamanian plants having related types of constituents displayed significant activities in an agar overlay thin layer chromatography assay against a susceptible strain of Candida albicans. These were the methanolic extract of the leaves of Schefflera systyla and Odontadenia puncticulosa and of the stems of Conostegia speciosa, that are species not previously investigated from a phytochemical viewpoint. For all plants, high-performance liquid chromatography (HPLC) antifungal activity based profiling allowed the rapid localization of antifungal agents that were further obtained by targeted isolation procedure by semi-preparative HPLC or medium pressure liquid chromatography (MPLC) after LC gradient transfer. Different hederagenin saponins and one aglycone were found to be responsible for the antifungal activities of the extracts. Alpha-hederin was the antifungal of S. systyla, pulsatilla saponin D and 3β-O-[β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosylhederagenin of O. puncticulosa and arjunolic acid of C. speciosa. Their minimal inhibitory concentration (MIC) against planktonic and biofilm cells of C. albicans were determined. Alpha-hederin was the most potent compound with a MIC of 4 µg mL -1 . Structurally related compounds (hederagenin, medicagenic acid 3-O-β-D-glucopyranoside and medicagenic acid) were used as standards and tested for comparison purposes. In order to better estimate the potential of these triterpenoids as antifungal agents, their cytological effects on C. albicans were determined by transmission electron microscopy (TEM) and the in vivo activity of alpha-hederin, medicagenic acid 3-O-β-D-glucopyranoside and medicagenic acid was evaluated for the first time in the Galleria mellonella larvae model. Keywords: triterpenoids, microfractionation, antifungal, Candida species, Galleria mellonella IntroductionFungal infections have recently increased worldwide and cause high morbidity and mortality rates among different groups of human patients. 1 The development of drug resistance in fungal pathogens compromises the efficacy of the limited number of therapeutic agents. 2The main fungal opportunistic human pathogens are Candida spp., and among them, the most common species is Candida albicans. 3 In the USA, Candida species are the fourth cause of nosocomial bloodstream infections. 4,5 Over 400,000 candidiasis infections are declared per year worldwide. 6 Moreover, Candida species display a tendency Identification of Triterpenoids from Schefflera systyla, Odontadenia puncticulosa and Conostegia speciosa J. Braz. Chem. Soc. 444 to grow as biofilms on implanted medical devices such as a central venous catheter. 7 Biofilm cells exhibit up to a 1,000-fold increase in resistance as compared to their planktonic counterparts 8 which may contribute to therapeutic failures. 9 These facts make urgent the need to identify new chemical entities that may lead to the disc...

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Amazonian Brazilian medicinal plants described by C.F.P. von Martius in the 19th century

Abstract: The data recorded by the German naturalist von Martius represent a rich, unexplored source of information about the traditional uses of Brazilian plants.

Cited by 74 publications

References 50 publications

Anti-promastigote Activity of the Amazon Plants

Anti-promastigote Activity of the Amazon Plants

Research with Chemistry and Pharmacology of Natural Products in Brazil: A Comparison with 70 Selected Countries from 5 Continents

Identification of Triterpenoids from Schefflera systyla, Odontadenia puncticulosa and Conostegia speciosa and In Depth Investigation of Their in vitro and in vivo Antifungal Activities

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