Amaryllidaceae and Sceletium alkaloids

Lewis, John R.

doi:10.1039/np9961300171

Cited by 19 publications

(9 citation statements)

References 7 publications

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“…This compound was previously isolated from H. puniceum and Leucojum autumnale L. (Quirion et al, 1991;Kihara et al, 1995;Lewis, 1996). The physical and spectroscopic data of 1 coincide with the proposed structure (Fig.…”

Section: Resultssupporting

confidence: 78%

3-O-Acetyl-narcissidine, a Bioactive Alkaloid from Hippeastrum puniceum Lam. (Amaryllidaceae)

Santana

Reina

Anaya

et al. 2008

Zeitschrift Für Naturforschung C

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In the context of the study on plant defensive compounds we have isolated the main alkaloid from Hippeastrum puniceum (Amaryllidaceae), 3-O-acetyl-narcissidine (1), and its biological activities tested against two divergent insect species and several plant species. 1 was isolated from the bioactive alkaloidal fraction of H. puniceum. Its chemical structure was established by spectroscopic analysis. The biological activity tests showed that 1 is an antifeedant against the polyphagous insect Spodoptera littoralis but not against the olyphage Leptinotarsa decemlineata. Furthermore, the root growth of Amaranthus hypochondriacus, Rottboellia cochinchinensis, Panicum maximum and Solanum lycopersicum was significantly affected by 1. These results suggest a plant protective role for H. puniceum alkaloids.

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Section: Resultssupporting

confidence: 78%

3-O-Acetyl-narcissidine, a Bioactive Alkaloid from Hippeastrum puniceum Lam. (Amaryllidaceae)

Santana

Reina

Anaya

et al. 2008

Zeitschrift Für Naturforschung C

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“…Among the six new galantamine-type alkaloids only 9-de-O-methyl-11β-hydroxygalantamine (13) showed a weak AChE inhibitory activity with IC 50 value 168.7 µM. The SAR of new galantamine derivatives alkaloids (11)(12)(13)(14)(15)(16) and known alkaloids isolated from the same plant species revealed that the 4,4a double bond and 9-OH are required for the AChE inhibitory activity, while the presence of the 11-OH group dramatically decreases AChE inhibitory activity [66].…”

Section: Effects On the Central Nervous System (Cns)mentioning

confidence: 99%

Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids

Koirala

Mérindol

et al. 2020

Molecules

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Alkaloids are an important group of specialized nitrogen metabolites with a wide range of biochemical and pharmacological effects. Since the first publication on lycorine in 1877, more than 650 alkaloids have been extracted from Amaryllidaceae bulbous plants and clustered together as the Amaryllidaceae alkaloids (AAs) family. AAs are specifically remarkable for their diverse pharmaceutical properties, as exemplified by the success of galantamine used to treat the symptoms of Alzheimer’s disease. This review addresses the isolation, biological, and structure activity of AAs discovered from January 2015 to August 2020, supporting their therapeutic interest.

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“…It was reported that lycorinehasa greater analgesic activity than aspirin and indomethacin [68,75]. It also displayed anticonvulsant effects when evaluated by the electrical stimulation test in rats [64].…”

Section: Other Biological Activitiesmentioning

confidence: 99%

An overview on the chemical and biological aspects of lycorine alkaloid

Khalifa

Attia

Fahim

et al. 2018

Journal of advanced Biomedical and Pharmaceutical Sciences

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Amaryllidaceae plants are currently appreciated as a plentiful source of unique bioactive alkaloids. Among them, lycorine is one of the major pyrrolophenanthridine alkaloids commonly isolated from different species of this family. Over the past years, lycorine has attracted great research interest owing to its superlative biological potential and pharmacological actions, including antitumor, antiangiogenic, antiviral, antibacterial, antimalarial, anti-parasite, antioxidant, hepatoprotective, analgesic, anti-inflammatory activities, and inhibition of ascorbic acid synthesis, among many others. Therefore, this review was undertaken to highlight the chemical, chromatographic, spectral, and biological aspects of this promising Amaryllidaceae alkaloid, together with a future perspective for its potential applications in the pharmaceutical field.

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Amaryllidaceae and Sceletium alkaloids

Cited by 19 publications

References 7 publications

3-O-Acetyl-narcissidine, a Bioactive Alkaloid from Hippeastrum puniceum Lam. (Amaryllidaceae)

3-O-Acetyl-narcissidine, a Bioactive Alkaloid from Hippeastrum puniceum Lam. (Amaryllidaceae)

Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids

An overview on the chemical and biological aspects of lycorine alkaloid

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