Amaryllidaceae and Sceletium alkaloids

Abstract

A great number of natural products, especially alkaloids, which exhibit a range of biological activities including acetylcholinesterase inhibition and antineoplastic, cardiovascular and immunostimulatory activities, have been isolated from the plants of the Amaryllidaceae family. this review summarizes isolation, biological activity, and synthetic studies of these alkaloids. The primary biosynthetic pathways of each type of alkaloids are also proposed.

Potentially Biomimetic Total Synthesis and Relative Stereochemical Assignment of (±)‐Gracilamine

“…[1] A great number of pharmacologically active alkaloids have been isolated from these plants, including galanthamine, [2] lycorine, [3] plicamine [4] and tazettine. [5] These alkaloids have shown significant biological effects, ranging from antitumor, antiviral, and antiinflammatory activities to immunostimulatory and acetylcholinesterase inhibitory activities.…”

“…[5] These alkaloids have shown significant biological effects, ranging from antitumor, antiviral, and antiinflammatory activities to immunostimulatory and acetylcholinesterase inhibitory activities. [1][2][3][4][5][6] The structural diversity and important biological activities of these natural products have attracted great attention from the synthetic chemistry community, particularly from within the pharmaceutical industry. [1][2][3][4][5] In 2005, gracilamine (1, Scheme 1), a structurally novel pentacyclic dinitrogenous alkaloid was isolated by Ünver and Kaya from an Amaryllidacae species, Galanthus gracilis, collected from a Turkish mountain.…”

Advances in Solution- and Solid-Phase Synthesis toward the Generation of Natural Product-like Libraries

“…[228][229][230] (+)-Plicamine and its enantiomer have an intriguing tetracyclic architecture with the 6,6-spirocyclic core with two skeletal nitrogens. Both of these isomers were synthesized using the solid-supported reagents and scavengers in multistep reaction sequences by Ley and co-workers.…”

Determination of pseudolycorine in the bulb of lycoris radiata by capillary electrophoresis combined with online electrochemiluminescence using ultrasonic-assisted extraction

“…There are some types of structure involved in this plant, e.g. lycorine, galanthamine, lycoramine, homolycorine, pseudolycorine and others [1][2][3]. In the recent years, attention has focused on these alkaloids because they exhibited pharmacological activity including antimalarial [4][5][6], antiviral [7,8], antineoplastic [9], and effects on central-nervous system [10].…”