Amantadine in a Multimodal Analgesic Regimen for Alleviation of Refractory Osteoarthritis Pain in Dogs

Lascelles, B. Duncan X.; Gaynor, James S.; Smith, Eric; Roe, Simon C.; Marcellin‐Little, Denis J.; Davidson, Gigi; Boland, Elizabeth A.; Carr, James A.

doi:10.1111/j.1939-1676.2007.0014.x

Cited by 148 publications

(94 citation statements)

References 57 publications

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“…The CSOM is a subjective instrument that satisfied some psychometric qualities in this clinical trial. The owner-described behaviors in the CSOM were similar to previously described behaviors in canine studies of OA symptoms and pain [7,19]. These similarities suggest the face validity k of the CSOM, which indicates that this measurement assesses the appropriate outcome [32].…”

Section: Discussionsupporting

confidence: 67%

“…The variety of OA signs suggests the need for the implementation of a clinical assessment that includes a broader variable profile than the current standardized OA profile. For this purpose, the client-specific outcome measures (CSOM) require the owner to report pain behavioral changes and/or impaired activities in their OA-afflicted dogs [18,19]. However, the promising CSOM have not met the technical validity b criteria [19].…”

Section: Introductionmentioning

confidence: 99%

“…For this purpose, the client-specific outcome measures (CSOM) require the owner to report pain behavioral changes and/or impaired activities in their OA-afflicted dogs [18,19]. However, the promising CSOM have not met the technical validity b criteria [19]. These data suggest that psychometric c support for the CSOM instrument is required.…”

Section: Introductionmentioning

confidence: 99%

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Clinical validity of outcome pain measures in naturally occurring canine osteoarthritis

Rialland

Bichot²,

Moreau

et al. 2012

BMC Vet Res

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BackgroundThe conceptual validity of kinetic gait analysis and disability outcome assessment methods has guided their use in the assessment of pain caused by osteoarthritis (OA). No consensus on the best clinical methods for pain evaluation in canine OA exists, particularly, when evaluating treatments where a smaller treatment effect is anticipated than with pharmacological pain killers. This study thus aimed at determining the technical validity of some clinical endpoints on OA pain in dogs using the green-lipped mussel (GLM)-enriched diet.Twenty-three adult dogs with clinical OA completed the prospective controlled study. All the dogs were fed a balanced diet over a 30-day control period followed by a GLM-enriched diet over a 60-day period. The kinetic gait analysis parameter (PVFBW, peak vertical force adjusted for body weight change), electrodermal activity (EDA), and a standardized multifactorial pain questionnaire (MFQ) were performed on day (D) 0 (inclusion), D30 (start) and D90 (end). The owners completed a client-specific outcome measures (CSOM) instrument twice a week. Motor activity (MA) was continuously recorded in seven dogs using telemetered accelerometric counts. We hypothesized that these methods would produce convergent results related to diet changes. A Type I error of 0.05 was adjusted to correct for the multiplicity of the primary clinical endpoints.ResultsNeither the EDA nor the MFQ were found reliable or could be validated. Changes in the PVFBW (Padj = 0.0004), the CSOM (Padj = 0.006) and the MA intensity (Padj = 0.02) from D0 to D90 suggested an effect of diet(s). Only the PVFBW clearly increased after the GLM-diet (Padj = 0.003). The CSOM exhibited a negative relationship with the PVFBW (P = 0.02) and MA duration (P = 0.02).ConclusionsThe PVFBW exhibited the best technical validity for the characterization of the beneficial effect of a GLM-enriched diet. The CSOM and MA appeared less responsive following a GLM-diet, but these measures appeared complementary to gait analysis. Apparently, the CSOM provides the capacity to rely on pain OA assessment influenced by both lameness quantification (PVFBW) and physical functioning (MA).

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Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

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Clinical validity of outcome pain measures in naturally occurring canine osteoarthritis

Rialland

Bichot²,

Moreau

et al. 2012

BMC Vet Res

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“…In humans, multimodal analgesia has been shown to decrease post-operative morbidity and mortality, improve quality of life and patient satisfaction, and decrease the associated costs to hospitals and insurance companies (Skinner, 2004). In addition to the general agreement of a clinical benefit to this approach (Lascelles & Main, 2002), there are also an increasing number of research studies in non-verbal species supporting multimodal analgesia (Lascelles et al, 2008; Slingsby, Murrell & Taylor, 2010; Martins et al, 2010). One simple way to include multimodal analgesia is the incorporation of a local anesthetic to desensitize a specific region, in combination with systemic analgesic administration.…”

Section: Introductionmentioning

confidence: 99%

The challenge of evaluating pain and a pre-incisional local anesthetic block

McKune

Pascoe

Lascelles

et al. 2014

PeerJ

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Background. Our objective was to test the effectiveness of a local anesthetic line block administered before surgery in reducing postoperative pain scores in dogs undergoing ovariohysterectomy (OVHX).Methods. This study is a prospective, randomized, blinded, clinical trial involving 59 healthy female dogs. An algometric pressure-measuring device was used to determine nociceptive threshold, and compared to three subjective pain scales. Group L/B received a line block of lidocaine (4 mg/kg) and bupivacaine (1 mg/kg) subcutaneously in the area of the incision site and saline subcutaneously as premedication; group L/BM (positive control) received a similar block and morphine (0.5 mg/kg) subcutaneously for premedication; and group SS (negative control) received a saline line block and saline premedication. Criteria for rescue analgesia were defined before the study. Dogs were assessed prior to surgery, at extubation (time 0) and at 2, 4, 6, 8 and 24 h post-recovery. The data were analyzed with one-way ANOVA, and a Split Plot Repeated Measures ANOVA with one grouping factor and one repeat factor (time). P < 0.05 was considered statistically significant.Results. Approximately 33% of dogs required rescue analgesia at some point during the study, with no significant difference between groups. There was no significant difference between treatment groups with any assessment method.Conclusions. As there were no statistically significant differences between positive and negative controls, the outcome of this technique cannot be proven.

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“…Owners then rate the degree of impairment. Use of this method has demonstrated that owners were able to assess differences in their pet's mobility when an analgesic was administered compared to a placebo (50). The use of CSOM has been shown to be a sensitive method for use in the pain management of dogs (51).…”

Section: Client-specific Outcome Measuresmentioning

confidence: 99%

The Challenges of Assessing Osteoarthritis and Postoperative Pain in Dogs

Sharkey

2013

AAPS J

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Abstract. The challenge of measuring pain in veterinary medicine is compounded by the lack of fully validated, reliable methods to measure and assess pain in nonverbal patients. In human medicine, there are numerous, validated pain assessment tools (PATs) for assessing various, specific types of pain. The advances in human medicine pain management and numerous validated pain scales should serve as incentives and templates to facilitate similar advances in the development of validated PATs for use in dogs (and other species). The limited number of canine PATs constrains our ability to adequately and reliably assess pain. Improving the ability to quantify osteoarthritis and postoperative pain in dogs would enhance the development of analgesics for animals, advance the management of animal pain, facilitate the use of animal pain models in preclinical trials for human analgesics, and provide insight into the quantification of pain responses in humans who lack the ability to adequately communicate. This review describes the need for practical, valid, and reliable PATs for use in veterinary patients and discusses some currently available PATs commonly used to evaluate acute and chronic pain in dogs.

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Amantadine in a Multimodal Analgesic Regimen for Alleviation of Refractory Osteoarthritis Pain in Dogs

Cited by 148 publications

References 57 publications

Clinical validity of outcome pain measures in naturally occurring canine osteoarthritis

Clinical validity of outcome pain measures in naturally occurring canine osteoarthritis

The challenge of evaluating pain and a pre-incisional local anesthetic block

The Challenges of Assessing Osteoarthritis and Postoperative Pain in Dogs

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