Amantadine hydrochloride treatment in heredodegenerative ataxias: a double blind study.

Botez, M.I.; Botez-Marquard, T; Elie, Robert; Pedraza, Olga Lucía; Goyette, Kristine; Lalonde, Robert

doi:10.1136/jnnp.61.3.259

Cited by 81 publications

(37 citation statements)

References 37 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In confirmation of preliminary open trials [1, 2], we [3]recently reported a double-blind short-term study showing an improvement in reaction time (RT) and movement time (MT) by patients with heredogenerative ataxias treated with amantadine hydrochoride, a dopamine-releasing agent and glutamate receptor blocker of the N-methyl- D -aspartate (NMDA) type [4, 5]. An improvement in performance on an ataxia scale has also been reported in Friedreich’s ataxia [6].…”

Section: Introductionsupporting

confidence: 52%

“…The present study is a follow-up of our previous double-blind trial [3], concerning the long-term effects of amantadine on patients with olivopontocerebellar atrophy (OPCA). Because of our positive results and ethical constraints, it was not possible to maintain the double-blind nature of the study or to use a placebo group.…”

Section: Introductionmentioning

confidence: 99%

“…RT and MT are dependent on cerebellar and basal ganglia subcortical circuits [1, 2, 3]. RT reflects the speed of information processing, whereas MT has little or no cognitive component, but instead is associated with motor control.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Amantadine Hydrochloride Treatment in Olivopontocerebellar Atrophy: A Long-Term Follow-Up Study

Botez

Botez-Marquard²,

Elie³

et al. 1999

Eur Neurol

View full text Add to dashboard Cite

The efficacy of amantadine, a dopamine-releasing agent and antagonist of the N-methyl-D-aspartate glutamate receptor, was evaluated in patients with olivopontocerebellar atrophy. By contrast to an untreated control group whose terminal performance deteriorated on 8 of 8 measurements of reaction time and movement time, patients treated with amantadine for a mean duration of over 40 months had improved performances in 1 of 4 reaction time measurements and in 3 of 4 movement time measurements and remained stable on the others. These results demonstrate long-term benefits of amantadine in olivopontocerebellar atrophy-induced deficits of movement initiation and movement completion.

show abstract

Section: Introductionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Amantadine Hydrochloride Treatment in Olivopontocerebellar Atrophy: A Long-Term Follow-Up Study

Botez

Botez-Marquard²,

Elie³

et al. 1999

Eur Neurol

View full text Add to dashboard Cite

show abstract

“…The beneficial results were attributed, either to a dopaminergic effect of the drug, or to blockade of NMDA receptors, an effect similar to that exercised by memantine (89).…”

Section: And Neurons (69) In T H I S D I S E a S E H O W E V E R mentioning

confidence: 83%

Neurochemistry and Neuropharmacology of the Cerebellar Ataxias

Gazulla¹,

Hermoso-Contreras²,

Tintoré³

2012

Spinocerebellar Ataxia

View full text Add to dashboard Cite

“…4) These lines of evidence suggest that dopaminergic system in the cerebellum is partly involved in motor system regulation.…”

mentioning

confidence: 99%

Taltirelin Improves Motor Ataxia Independently of Monoamine Levels in Rolling Mouse Nagoya, a Model of Spinocerebellar Atrophy

Nakamura

Honda

Kimura

et al. 2005

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

The major symptom of spinocerebellar atrophy (SCA) is cerebellar or spinal ataxia. Noradrenergic and serotonergic fibers project to the cerebellum and the spinal cord, and regulate the motor systems. Furthermore, dopamine (DA)-containing immunoreactive fibers and some dopaminergic receptor subtypes have been found in rat cerebellar cortex, 1) and microinjection of dopaminergic agonists and antagonists into the rat cerebellum reportedly decrease locomotor activity. 2,3) In patients with olivo-ponto-cerebellar atrophy, which is a type of spinocerebellar atrophy, the DA releaser amantadine improves their ataxia.4) These lines of evidence suggest that dopaminergic system in the cerebellum is partly involved in motor system regulation.Rolling mouse Nagoya (RMN) has been extensively studied morphologically and physiologically as an animal model of SCA. This mouse is shown to have the mutation in the gene encoding the P/Q-type voltage-dependent Ca 2ϩ channel a 1A subunit and changes of voltage sensitivity in cerebellar Purkinje cells. 5) And the apoptotic cell death of cerebellar granule cells was increased in RMN, which is considered as an example of delayed cerebellar maturation. 6) Although some reports have indicated that the metabolism of noradrenaline (NA) 7) or serotonin (5-HT) 8) is altered in ataxic mice including RMN, no study has investigated the DA level in their cerebellum, brain stem and spinal cord.Thyrotropin-releasing hormone (TRH) and its stable analogs produce a number of physiological and behavioral effects in both animals and humans. Several studies have showed that these agents enhance locomotor activity and ameliorate cerebellar ataxia in rats and mice. [9][10][11][12][13][14][15] In addition, these agents exert neuroprotective effects in rodents with spinal cord injury and brain trauma [16][17][18][19][20] and anticonvulsive effects in amygdaloid-kindled rats. 21) Clinical studies have also shown that TRH, and its synthetic analog taltilerin hydrate, are effective for treatment of hereditary ataxias, including olivo-ponto-cerebellar atrophy and Machado-Joseph disease, which is a type of spinocerebellar atrophy. [22][23][24] Taltirelin hydrate and another TRH analog, YM-14673, have been shown to alter the metabolism of acetylcholine 25,26) and DA,27) and activate the dopaminergic system. 11,13,28) In the present study, we measured the contents and concentrations of DA as well as NA and 5-HT, and the effects of the synthetic TRH analog taltirelin hydrate on these monoamine levels and locomotor activity, in the murine ataxia model RMN. MATERIALS AND METHODS Preparation of Ataxic Model MiceAll the experimental protocols were approved by the Animal Care and Use Committee of Nagoya City University and were conducted in accordance with the guidelines of the National Institute of Health and The Japanese Pharmacological Society.The RMN model was produced at Nagoya City University, but originally obtained from Dr. S. Oda, the Laboratory of Animal Management and Resources, Division of Biosphere Dynamics, D...

show abstract

Amantadine hydrochloride treatment in heredodegenerative ataxias: a double blind study.

Cited by 81 publications

References 37 publications

Amantadine Hydrochloride Treatment in Olivopontocerebellar Atrophy: A Long-Term Follow-Up Study

Amantadine Hydrochloride Treatment in Olivopontocerebellar Atrophy: A Long-Term Follow-Up Study

Neurochemistry and Neuropharmacology of the Cerebellar Ataxias

Taltirelin Improves Motor Ataxia Independently of Monoamine Levels in Rolling Mouse Nagoya, a Model of Spinocerebellar Atrophy

Contact Info

Product

Resources

About