Amantadine for influenza A.

Nicholson, Karl G.; Wiselka, Martin

doi:10.1136/bmj.302.6774.425

Cited by 35 publications

(20 citation statements)

References 17 publications

(11 reference statements)

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“…Amantadine (1-adamantanamine) is an antiviral agent active against the influenza A virus [6,7]. Amantadine exerts antiviral activity against other viruses, including flaviridae to which HCV belongs [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of amantadine in chronic hepatitis C: a meta-analysis

Deltenre

Henrion

Canva

et al. 2004

Journal of Hepatology

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Section: Introductionmentioning

confidence: 99%

Evaluation of amantadine in chronic hepatitis C: a meta-analysis

Deltenre

Henrion

Canva

et al. 2004

Journal of Hepatology

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“…Influenza viruses are responsible for a high proportion of respiratory disease with infection caused by influenzaA or B, or both, recurring each winter (Nicholson and Wiselka, 1991).The recent outbreak of influenzaA in 1989-90 in the UK was a reminder of how serious the disease can be, since approximately 26000 deaths were associated directly or indirectly with the outbreak (Curwen et al 1990). Deaths attributed directly to the virus were not confined just to the elderly but occurred in all age groups inclUding babies (personal communication, PHLS).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Influenza A and B Viruses by 2′-Deoxy-2′-Fluororibosides

Tisdale

Appleyard

Tuttle

et al. 1993

Antivir Chem Chemother

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A series of 2′-deoxy-2′-fluororibosides were evaluated for anti-influenza activity in cell culture and in the mouse pneumonia model. Many were found to be potent inhibitors of Influenza A, in chick embryo fibroblast cells (IC50's 0.1–2.9 μM), and in reducing mouse lung virus titres (1–3 log10 units). Purine analogues proved the most effective, but their activity was an order of magnitude higher in MDCK cells. Anti-influenza activity correlated with intracellular triphosphate levels and with substrate specificity of 2′-deoxycytidine kinase. 2′-deoxy-2′-fluoroguanosine selected for further study was active against all influenza A and B strains tested, including one clinical isolate which proved extremely sensitive when assayed in human tracheal cultures. In vivo, 2′-deoxy-2′-fluoroguanosine (2′-fluorodGuo) was significantly more effective than amantadine or ribavirin in reducing mouse lung virus titre when treatment commenced after infection.

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“…Según lo publicado por Nicholson, los amantadanes (como amantadine y rimantadine) son eficaces para el tratamiento de la infección aguda de la gripe A si la terapia antivírica se comienza en el plazo de las primeras 24 horas tras el inicio de la enfermedad, reduciendo la fiebre y los síntomas 92 .…”

Section: Tratamiento Experiencias Actuales Con Antiviralesunclassified

Gripe aviar: lo que un intensivista debe conocer

Casillas¹,

Fernandez²,

Varon³

2008

Medicina Intensiva

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En el siglo pasado, la humanidad ha hecho frente a tres de las mayores pandemias de infecciones por el virus de la gripe. La primera fue en 1918, y causó una cantidad significativa de muertes. Éste ha sido también capaz de cruzar la barrera de la especie y afectar a los mamíferos y, lo más preocupante, a los seres humanos. Desde entonces se han publicado varios brotes en el sudeste de Asia. Una gran cantidad de pacientes presenta un curso severo que desarrolla neumonía y disfunción, que implica al hígado, los riñones, el cerebro y los pulmones.Puesto que el virus carece de control regulador de la división genética, experimenta mutaciones constantes que conducen a nuevos subtipos y a nuevas cepas. Los únicos fármacos que han mostrado cierta protección son oseltamivir y zanamivir. Es crucial desarrollar vacunas eficaces y no costosas para prevenir la extensión del virus y la infección, no solamente en seres humanos sino también en aves. PALABRAS CLAVE: gripe aviar, fallo respiratorio agudo, virus H5N1, neuraminidasa, oseltamivir. BIRD FLU: WHAT THE INTENSIVIST MUST KNOWIn the last century, humankind has faced 3 major pandemics of influenza virus infections. The first one occurred in 1918 and caused a significant amount of deaths. It was also capable of crossing over species barrier and affecting mammals, and most worrisome, humans. Since then several outbreaks have been reported in the Southeast of Asia. Many patients with the flu-like illness have a severe course and the patient develops pneumonia and in some cases multiorgan failure involving liver, kidneys, brain and lungs.Since the virus lacks regulatory control of genetic division it undergoes constant mutations leading to new subtypes and, sometimes, new strains. The only drugs that have shown some protection are oseltamivir and zanamivir. It is crucial to develop effective and non-expensive vaccines to prevent the virus spread and infection not only in humans but in birds too.

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Amantadine for influenza A.

Cited by 35 publications

References 17 publications

Evaluation of amantadine in chronic hepatitis C: a meta-analysis

Evaluation of amantadine in chronic hepatitis C: a meta-analysis

Inhibition of Influenza A and B Viruses by 2′-Deoxy-2′-Fluororibosides

Gripe aviar: lo que un intensivista debe conocer

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