Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition

Oikawa, Naoto; Kimura, Naoko; Yanagisawa, Katsuhiko

doi:10.1016/j.brainres.2009.12.005

Cited by 89 publications

(94 citation statements)

References 68 publications

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“…The two age ranges were similarly represented. These monkeys survive in captivity approximately 25 to 35 years or about a quarter to a third of the life span of humans (Kaufman et al 2005;Rao et al 1998;Weigl 2005;Freimer et al 2007;Fears et al 2009;Oikawa et al 2010). Therefore, the young adult group averaging 9 years of age approximates humans that are about 30 years of age, whereas the old adult group, averaging 20 years of age, approximates humans of about 70 years of age.…”

Section: Discussionmentioning

confidence: 99%

Aging and physical mobility in group-housed Old World monkeys

Shively

Willard

et al. 2011

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While indices of physical mobility such as gait speed are significant predictors of future morbidity/ mortality in the elderly, mechanisms of these relationships are not understood. Relevant animal models of aging and physical mobility are needed to study these relationships. The goal of this study was to develop measures of physical mobility including activity levels and gait speed in Old World monkeys which vary with age in adults. Locomotor behaviors of 21 old (x0 20 yoa) and 24 young (x09 yoa) socially housed adult females of three species were recorded using focal sample and ad libitum behavior observation methods. Selfmotivated walking speed was 17% slower in older than younger adults. Likewise, young adults climbed more frequently than older adults. Leaping and jumping were more common, on average, in young adults, but this difference did not reach significance. Overall activity levels did not vary significantly by age, and there were no significant age by species interactions in any of these behaviors. Of all the behaviors evaluated, walking speed measured in a simple and inexpensive manner appeared most sensitive to age and has the added feature of being least affected by differences in housing characteristics. Thus, walking speed may be a useful indicator of decline in physical mobility in nonhuman primate models of aging.

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Section: Discussionmentioning

confidence: 99%

Aging and physical mobility in group-housed Old World monkeys

Shively

Willard

et al. 2011

AGE

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“…Finally, neurofibrillary tangles are a second critical and diagnostic feature of AD that is particularly related to the death of neurons but there is no clear evidence that neurofibrillary tangles are ever present in the rhesus monkey brain (Kimura et al 2003;and Finch and Austad, this publication). And while there are a few recent studies that report A-beta and phosphorylated tau in the monkey brain and assert that this makes the rhesus a good model for AD pathology (e.g., Oikawa et al 2010), none of these papers provide evidence that this pathology leads to the death or loss of neurons.…”

Section: The Non-human Primate As a Model Of Normative Agingmentioning

confidence: 99%

Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline

Kohama

Rosene

Sherman

2011

AGE

115

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The cognitive decline associated with normal aging was long believed to be due primarily to decreased synaptic density and neuron loss. Recent studies in both humans and non-human primates have challenged this idea, pointing instead to disturbances in white matter (WM) including myelin damage. Here, we review both cross-sectional and longitudinal studies in humans and non-human primates that collectively support the hypothesis that WM disturbances increase with age starting at middle age in humans, that these disturbances contribute to age-related cognitive decline, and that age-related WM changes may occur as a result of free radical damage, degenerative changes in cells in the oligodendrocyte lineage, and changes in microenvironments within WM.

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“…In contrast to APP CTF␤, the phosphorylation level of pTau/total Tau (pTau/total Tau) tended to increase versus aging but not significantly (R 2 ϭ 0.0389, p ϭ 0.2229). Because cynomolgus monkeys have been reported to show amyloid plaques in individuals over 20 years of age (27,48), changes in the phosphorylation level of CTF␤ and Tau were analyzed both in younger (Ͻ20 years old) and older (Ͼ20 years old) individuals, respectively (supplemental Fig. S8).…”

Section: Phosphorylation State Of App Carboxyl-terminal Fragments At Thrmentioning

confidence: 99%

Membrane-Microdomain Localization of Amyloid β-Precursor Protein (APP) C-terminal Fragments Is Regulated by Phosphorylation of the Cytoplasmic Thr668 Residue

Matsushima

Saito

Elliott

et al. 2012

Journal of Biological Chemistry

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Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition

Cited by 89 publications

References 68 publications

Aging and physical mobility in group-housed Old World monkeys

Aging and physical mobility in group-housed Old World monkeys

Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline

Membrane-Microdomain Localization of Amyloid β-Precursor Protein (APP) C-terminal Fragments Is Regulated by Phosphorylation of the Cytoplasmic Thr668 Residue

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