Alzheimer's drug helps brain function after radiotherapy

McCaffrey, Pat

doi:10.1016/s1470-2045(06)70683-0

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Similarity and Relationship To Forms Of Senile Dementia Incl1

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2016

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“…Two effective remedies were memantine (26,27) and donepezil (28,29). Both are drugs to treat Alzheimer's disease and both have different targets of action (30).…”

Section: Similarity and Relationship To Forms Of Senile Dementia Inclmentioning

confidence: 99%

A link between vascular damage and cognitive deficits after whole-brain radiation therapy for cancer: A clue to other types of dementia?

Yamada

2016

DD&T

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“…Two effective remedies were memantine (26,27) and donepezil (28,29). Both are drugs to treat Alzheimer's disease and both have different targets of action (30).…”

Section: Similarity and Relationship To Forms Of Senile Dementia Inclmentioning

confidence: 99%

A link between vascular damage and cognitive deficits after whole-brain radiation therapy for cancer: A clue to other types of dementia?

Yamada

2016

DD&T

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Exposure to⁵⁶Fe-Particle Radiation Accelerates Electrophysiological Alterations in the Hippocampus of APP23 Transgenic Mice

Vlkolinský

Titova

Krucker³

et al. 2010

Radiation Research

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An unavoidable complication of space travel is exposure to high-charge, high-energy (HZE) particles. In animal studies, exposure of the CNS to HZE-particle radiation leads to neurological alterations similar to those seen in aging or Alzheimer's disease. In this study we examined whether HZE-particle radiation accelerated the age-related neuronal dysfunction that was previously described in transgenic mice overexpressing human amyloid precursor protein (APP). These APP23 transgenic mice exhibit age-related behavioral abnormalities and deficits in synaptic transmission. We exposed 7-week-old APP23 transgenic males to brain-only (56)Fe-particle radiation (600 MeV/nucleon; 1, 2, 4 Gy) and recorded synaptic transmission in hippocampal slices at 2, 6, 9, 14 and 18-24 months. We stimulated Schaeffer collaterals and recorded field excitatory postsynaptic potentials (fEPSP) and population spikes (PS) in CA1 neurons. Radiation accelerated the onset of age-related fEPSP decrements recorded at the PS threshold from 14 months of age to 9 months and reduced synaptic efficacy. At 9 months, radiation also reduced PS amplitudes. At 6 months, we observed a temporary deficit in paired-pulse inhibition of the PS at 2 Gy. Radiation did not significantly affect survival of APP23 transgenic mice. We conclude that irradiation of the brain with HZE particles accelerates Alzheimer's disease-related neurological deficits.

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Alzheimer's drug helps brain function after radiotherapy

Cited by 2 publications

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A link between vascular damage and cognitive deficits after whole-brain radiation therapy for cancer: A clue to other types of dementia?

A link between vascular damage and cognitive deficits after whole-brain radiation therapy for cancer: A clue to other types of dementia?

Exposure to⁵⁶Fe-Particle Radiation Accelerates Electrophysiological Alterations in the Hippocampus of APP23 Transgenic Mice

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Alzheimer's drug helps brain function after radiotherapy

Cited by 2 publications

References 0 publications

A link between vascular damage and cognitive deficits after whole-brain radiation therapy for cancer: A clue to other types of dementia?

A link between vascular damage and cognitive deficits after whole-brain radiation therapy for cancer: A clue to other types of dementia?

Exposure to56Fe-Particle Radiation Accelerates Electrophysiological Alterations in the Hippocampus of APP23 Transgenic Mice

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Exposure to⁵⁶Fe-Particle Radiation Accelerates Electrophysiological Alterations in the Hippocampus of APP23 Transgenic Mice