“…The CSF collection by lumbar puncture is an invasive, expensive and time-consuming procedure; therefore, the detection of biomarker molecules in blood would be more accessible. Nonetheless, in comparison with CSF biomarkers, discovering reliable biomarkers for AD in peripheral blood has not been successful and has not been a solid diagnostic method 4 . Therefore, exploring some interesting biomarkers and establishing convenient techniques with low cost, rapid and high accuracy which could be used routinely in clinical diagnosis are still important goals for all researchers.…”