Alzheimer's disease pathogenesis: The role of disturbed sleep in attenuated brain plasticity and neurodegenerative processes

Havekes, Robbert; Heckman, Pim R. A.; Wams, Emma J.; Stasiukonytė, Neringa; Meerlo, Peter; Eisel, Ulrich

doi:10.1016/j.cellsig.2019.109420

Cited by 24 publications

(18 citation statements)

References 112 publications

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“…Sleep deprivation is prevalent in spaceflight ( Barger et al, 2014 ). It not only affects cognitive performance and metabolic health ( Banks and Dinges, 2007 ), but also is a potent risk factor for the development of neurodegenerative disease ( Havekes et al, 2019 ). For these reasons, insufficient sleep is likely an important contributing factor to spaceflight induced changes in brain structure and function.…”

Section: Level 1 Priority Recommendationsmentioning

confidence: 99%

Future research directions to identify risks and mitigation strategies for neurostructural, ocular, and behavioral changes induced by human spaceflight: A NASA-ESA expert group consensus report

Seidler

Stern

Basner

et al. 2022

Front. Neural Circuits

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A team of experts on the effects of the spaceflight environment on the brain and eye (SANS: Spaceflight-Associated Neuro-ocular Syndrome) was convened by NASA and ESA to (1) review spaceflight-associated structural and functional changes of the human brain and eye, and any interactions between the two; and (2) identify critical future research directions in this area to help characterize the risk and identify possible countermeasures and strategies to mitigate the spaceflight-induced brain and eye alterations. The experts identified 14 critical future research directions that would substantially advance our knowledge of the effects of spending prolonged periods of time in the spaceflight environment on SANS, as well as brain structure and function. They used a paired comparison approach to rank the relative importance of these 14 recommendations, which are discussed in detail in the main report and are summarized briefly below.

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Section: Level 1 Priority Recommendationsmentioning

confidence: 99%

Future research directions to identify risks and mitigation strategies for neurostructural, ocular, and behavioral changes induced by human spaceflight: A NASA-ESA expert group consensus report

Seidler

Stern

Basner

et al. 2022

Front. Neural Circuits

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“…(18) Otra propuesta explicativa de la asociación bidireccional entre las orexinas y los precursores de la DA establece que tanto la alteración del sueño como el aumento en los niveles de las orexinas son factores de riesgo para DA; la presencia de niveles patológicos de Aβ y Tau, proteínas asociadas con neurodegeneración en DA, afecta el proceso de limpieza de residuos cerebrales (sistema glinfático) y altera el sistema de las orexinas, lo cual conlleva a alteraciones del sueño características en la DA. (45,60,61)…”

Section: Estudios Clínicos Relacionados Con Demencia Tipo Alzheimer Y...unclassified

Las orexinas como biomarcadores para demencia tipo Alzheimer y relación con síntomas neuropsiquiátricos

Lozano-Tovar¹,

Monroy-Jaramillo²,

Rodríguez-Agudelo³

2022

Rev. chil. neuro-psiquiatr.

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The most studied biomarkers in Alzheimer's dementia (AD) are elevated levels of Aβ42 and Tau protein in cerebrospinal fluid. Given the complexity of the cognitive symptomatology and neuropsychiatric symptoms (NPS) of this pathology, some recent studies propose substances such as orexins as a therapeutic target for AD and NPS. The present work aims to review recent scientific publications that have analyzed the association between orexins, PNS and AD in humans. There are some animal models that have evaluated orexins as possible biomarkers both for research and in the clinical area. This review also describes studies that suggest orexins as possible biomarkers in AD, given their relationship with Aβ42 and Tau protein, and other studies that associate them with the presence of SNPs, especially sleep disturbance. It is hypothesized that the presence of SNPs in AD is associated with orexins, because this system influences hypothalamic functioning and indirectly in brain areas that regulate behavior. However, further research is still lacking, mainly longitudinal studies to clearly know the influence of orexins on SNPs.

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“…L-Glutamate in abnormal conditions acts as neurotoxins also called endogenous amino acids (EAA). These toxins open membrane cation channels to an excessive influx of sodium and a passive influx of Calcium and water which results in acute neuronal swelling [23,24]. Memantine (Ebixa®, Axura®, Namenda®, Akatinol®), a partial antagonist of NMDA receptors was approved (2003) for treating moderate to severe AD.…”

Section: Nmda-receptor Partial Antagonistmentioning

confidence: 99%

Alzheimer’s Disease: Perspective on Therapeutic Options and Recent Hallmarks in Clinical Research

Beera¹,

Seethamraju²,

Nori³

2021

Int j pharm res allied sci

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Alzheimer's disease (AD) is a progressive neurodegenerative, a primarily concerned and leading cause of mortality worldwide which has no cure so far, of the world. The disease progresses from memory loss to cognitive decline gradually. The severity of Alzheimer's grows up from mild, moderate to severe. Hallmarks of the research of AD reported, are the identification of amyloid-beta (Aβ) plaques and tau protein tangles between and within the neuronal cells, oxidative stress, low acetylcholine, and most importantly the genetic connection. Diagnosis of this condition is not so simple since there is no single test that identifies Alzheimer's as early as possible. The therapies for the disease just provide symptomatic relief but not cure. The present review emphasizes the disease burden in the world, neurobiological aspects, and its management through conventional drug therapies along with novel research on therapeutic strategies, new drugs which showed excellent results that are to be approved and were approved, including investigations on plant medicine.

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Alzheimer's disease pathogenesis: The role of disturbed sleep in attenuated brain plasticity and neurodegenerative processes

Cited by 24 publications

References 112 publications

Future research directions to identify risks and mitigation strategies for neurostructural, ocular, and behavioral changes induced by human spaceflight: A NASA-ESA expert group consensus report

Future research directions to identify risks and mitigation strategies for neurostructural, ocular, and behavioral changes induced by human spaceflight: A NASA-ESA expert group consensus report

Las orexinas como biomarcadores para demencia tipo Alzheimer y relación con síntomas neuropsiquiátricos

Alzheimer’s Disease: Perspective on Therapeutic Options and Recent Hallmarks in Clinical Research

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