Alzheimer's disease heterogeneity revealed by neuroanatomical normative modeling
Flavia Loreto,
Serena Verdi,
Seyed Mostafa Kia
et al.
Abstract:INTRODUCTIONOverlooking the heterogeneity in Alzheimer's disease (AD) may lead to diagnostic delays and failures. Neuroanatomical normative modeling captures individual brain variation and may inform our understanding of individual differences in AD‐related atrophy.METHODSWe applied neuroanatomical normative modeling to magnetic resonance imaging from a real‐world clinical cohort with confirmed AD (n = 86). Regional cortical thickness was compared to a healthy reference cohort (n = 33,072) and the number of ou… Show more
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