Alzheimer's disease, enzyme targets and drug discovery struggles: From natural products to drug prototypes

Silva, Tiago; Reis, Joana; Teixeira, José; Borges, Fernanda

doi:10.1016/j.arr.2014.03.008

Cited by 129 publications

(81 citation statements)

References 231 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…GSK-3 is an important kinase in AD and other pathophenotypes. It phosphorylates the cytoskeletal protein tau, facilitating the formation of neurofibrillary tangles, which are pathologic intracellular aggregates that disturb axonal transport and lead to neuronal death (Silva et al, 2014). Therefore, it has been speculated that GSK-3 inhibition might have the double benefit of preventing neurofibrillary tangle formation and NRF2 degradation.…”

Section: B Protein-protein Interaction Inhibitors For Nuclear Factormentioning

confidence: 99%

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

et al. 2018

View full text Add to dashboard Cite

Section: B Protein-protein Interaction Inhibitors For Nuclear Factormentioning

confidence: 99%

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

et al. 2018

View full text Add to dashboard Cite

“…[7,12]. Hence, the wide range of pathological features in AD and the inability to meliorate the disease condition warrants a growing set of promising therapeutic targets towards AD therapy and management [13,14]. The current review focuses on the importance of carbohydrates from marine derived compounds against ND.…”

Section: Prevalence and Current Therapymentioning

confidence: 99%

Marine Carbohydrate Based Therapeutics for Alzheimer Disease-Mini Review

Manig¹,

Ramachandran²,

Saravanan³

2015

J Neurol Neurosci

View full text Add to dashboard Cite

Neurological disorders occur due to recognition of neurological repairs and resources are indirectly scarce, especially in low income and developing countries. They are disorders of the central nervous system and common cause of physiological and economic burden worldwide. Alzheimer's disease (AD) and other dementias is one of the progressive neurodegenerative disorders which causes memory loss and cognitive impairment due to aggregation of misfolded proteins and neurofibrillar tangles in brain. The failure of the conventional drugs to decline disease progression accompanied with numerous adverse effects has forced the researchers to look for efficient drug candidates from alternate natural resources. The marine reservoir with its large biodiversity and untapped resource potential holds numerous molecules of biomedical and clinical importance. In this review, we hypothesize the utilization of the sulfated polysaccharides as glycobased mimetics, leading to the prevention of aggregation of plaques and protein tangles. With further screening and validation, the carbohydrates from the marine sources, thus hold immense potentials to function as alternative therapeutic agent against neurological disorders.

show abstract

“…It is found mainly in neuromuscular junctions and synapses, and plays a critical role in the transmission of nervous information. Its inhibition, leading to an accumulation of acetylcholine and the blockade of neurotransmission, is of importance notably for drug detoxification [74] or Alzheimerʼs disease treatment (improvement of cognitive function) [75]. Compound 1 isolated from S. globulifera is a potent inhibitor of acetylcholinesterase and butyrylcholinesterase [IC 50 = AChE 0.88 μΜ (galanthamine = 0.5) and BChE = 2.77 μΜ (galanthamine = 8.5)] (l " Table 4).…”

Section: Anticholinesterase Activitymentioning

confidence: 99%

Untitled

2015

Planta Med

View full text Add to dashboard Cite

Fruits are drupes (4-5 cm), ovoid, or globular. Seeds are intensively red inside [10][11][12]. This species is also characterized by important morphological variations, which seem to be deAbstract ! Symphonia globulifera has been widely used in traditional medicine and has therefore been subjected to several phytochemical studies in the American and African continents. Interestingly, some disparities have been observed concerning its metabolic profile. Several phytochemical studies of S. globulifera have led to the identification of more than 40 compounds, including several polycyclic polyprenylated acylphloroglucinols. Biological evaluations have pointed out the promising biological activities of these secondary metabolites, mostly as antiparasitic or antimicrobial, confirming the traditional use of this plant. The purpose of this review is to describe the natural occurrence, botanical aspects, ethnomedicinal use, structure, and biogenesis, as well as biological activities of compounds isolated from this species according to their provenance.

show abstract

Alzheimer's disease, enzyme targets and drug discovery struggles: From natural products to drug prototypes

Cited by 129 publications

References 231 publications

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

Marine Carbohydrate Based Therapeutics for Alzheimer Disease-Mini Review

Untitled

Contact Info

Product

Resources

About