Alzheimer’s Disease: A Clinical Perspective

Xu, Weili; Marseglia, Anna; Ferrari, Camilla; Wang, Huixin

doi:10.5772/54539

Cited by 2 publications

(2 citation statements)

References 137 publications

(150 reference statements)

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“…The reason for this decline is not well understood. However, several hypotheses, causes, and factors have been proposed to explain the deterioration in cognitive and physical function [ 136 ]. One potential cause is the poor production of mitochondrial proteins due to the impairment of cellular energy production [ 137 ].…”

Section: Mitochondrial Pathology In Nddsmentioning

confidence: 99%

Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders

Ashraf

Almikhlafi

Karami

et al. 2023

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Abnormal mitochondrial morphology and metabolic dysfunction have been observed in many neurodegenerative disorders (NDDs). Mitochondrial dysfunction can be caused by aberrant mitochondrial DNA, mutant nuclear proteins that interact with mitochondria directly or indirectly, or unknown reasons. Since mitochondria play a significant role in neurodegeneration, mitochondria- targeted therapies represent a prosperous direction for the development of novel drug compounds that can be used to treat NDDs. This review gives a brief description of how mitochondrial abnormalities lead to various NDDs such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. We further explore the promising therapeutic effectiveness of mitochondria-directed antioxidants, MitoQ, MitoVitE, MitoPBN, and dimebon. We have also discussed the possibility of mitochondrial gene therapy as a therapeutic option for these NDDs.

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Section: Mitochondrial Pathology In Nddsmentioning

confidence: 99%

Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders

Ashraf

Almikhlafi

Karami

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The Global Burden of Disease Study estimated that 57.4 million people globally were living with dementia in 2019 and this is predicted to reach 152.8 million people by 2050 [2]. Dementia is an umbrella syndrome characterised primarily by progressive deterioration in multiple cognitive domains, causing impairment in daily functioning across social, physical, and professional spheres [3,4]. The elderly are those primarily affected by AD [5], though this is not necessarily a direct outcome of ageing [6].…”

Section: Introductionmentioning

confidence: 99%

Immunotherapies for Alzheimer’s Disease—A Review

et al. 2022

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Alzheimer’s disease (AD) is a chronic neurodegenerative disorder that falls under the umbrella of dementia and is characterised by the presence of highly neurotoxic amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFTs) of tau protein within the brain. Historically, treatments for AD have consisted of medications that can slow the progression of symptoms but not halt or reverse them. The shortcomings of conventional drugs have led to a growing need for novel, effective approaches to the treatment of AD. In recent years, immunotherapies have been at the forefront of these efforts. Briefly, immunotherapies utilise the immune system of the patient to treat a condition, with common immunotherapies for AD consisting of the use of monoclonal antibodies or vaccines. Most of these treatments target the production and deposition of Aβ due to its neurotoxicity, but treatments specifically targeting tau protein are being researched as well. These treatments have had great variance in their efficacy and safety, leading to a constant need for the research and development of new safe and effective treatments.

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Alzheimer’s Disease: A Clinical Perspective

Cited by 2 publications

References 137 publications

Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders

Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders

Immunotherapies for Alzheimer’s Disease—A Review

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