Alzheimer Disease and Other Dementias

Petit, Dominique; Montplaisir, Jacques; Louis, Erik K. St.; Boeve, Bradley F.

doi:10.1016/b978-0-323-24288-2.00096-9

Cited by 4 publications

(2 citation statements)

References 173 publications

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“…As it progresses, patients with PD develop cognitive decline, dementia, as well as mood and behavioral disorders. Additionally, circadian dysfunction also occurs in PD and is characterized by many sleep-related pathologies, such as excessive drowsiness, insomnia, night terrors, REM cycle disruptions, and sleep fragmentation ( Petit et al, 2017 ; Trenkwalder et al, 2017 ). Furthermore, circadian dysfunction coupled with neuroinflammation is a risk factor for PD.…”

Section: α-Synuclein Proteinopathiesmentioning

confidence: 99%

“…LBDs are the second most common type of degenerative dementia affecting the elderly ( Petit et al, 2017 ). A pilot study investigating clock gene disturbances in dementia patients found that LBD patients had a higher frequency of aberrant methylation patterns of core clock genes compared to other dementia patients ( Liu et al, 2008 ).…”

Section: α-Synuclein Proteinopathiesmentioning

confidence: 99%

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The Molecular Clock and Neurodegenerative Disease: A Stressful Time

Carter

Justin

Gulick

et al. 2021

Front. Mol. Biosci.

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Circadian rhythm dysfunction occurs in both common and rare neurodegenerative diseases. This dysfunction manifests as sleep cycle mistiming, alterations in body temperature rhythms, and an increase in symptomatology during the early evening hours known as Sundown Syndrome. Disruption of circadian rhythm homeostasis has also been implicated in the etiology of neurodegenerative disease. Indeed, individuals exposed to a shifting schedule of sleep and activity, such as health care workers, are at a higher risk. Thus, a bidirectional relationship exists between the circadian system and neurodegeneration. At the heart of this crosstalk is the molecular circadian clock, which functions to regulate circadian rhythm homeostasis. Over the past decade, this connection has become a focal point of investigation as the molecular clock offers an attractive target to combat both neurodegenerative disease pathogenesis and circadian rhythm dysfunction, and a pivotal role for neuroinflammation and stress has been established. This review summarizes the contributions of molecular clock dysfunction to neurodegenerative disease etiology, as well as the mechanisms by which neurodegenerative diseases affect the molecular clock.

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Section: α-Synuclein Proteinopathiesmentioning

confidence: 99%

Section: α-Synuclein Proteinopathiesmentioning

confidence: 99%