Alzheimer and vascular dementia in the elderly patients

Seetlani, Naresh Kumar; Kumar, Narindar; Khalid, Imran; Ali, Asif; Shams, Nadia; Sheikh, Taha

doi:10.12669/pjms.325.10792

Cited by 14 publications

(13 citation statements)

References 21 publications

(14 reference statements)

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“… 33 Estimates from studies conducted in South Africa indicate that the prevalence of dementia ranges from 3.8% to 11.0% for adults aged 65 years or older. 33 , 34 , 35 In this study, we examined multidimensional poverty and dementia in older adults in Soweto, South Africa. Our objective was to examine the association between multidimensional poverty and dementia and the role of various dimensions of deprivation in overall poverty.…”

Section: Introductionmentioning

confidence: 99%

Association of Multidimensional Poverty With Dementia in Adults Aged 50 Years or Older in South Africa

et al. 2022

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Key Points Question Is multidimensional poverty associated with dementia in older adults in low- and middle-income countries? Findings In this cross-sectional study of 227 adults aged 50 years or older living in Soweto, Johannesburg, South Africa, 20% of adults with dementia were poor compared with 10% of those without dementia, with a difference of 118% on the Multidimensional Poverty Index. The risk of dementia was 2.31 times higher for adults who were multidimensionally poor. Meaning These results suggest that public policies addressing factors associated with poverty may be helpful to delay the onset and reduce the prevalence of dementia among older adults.

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Section: Introductionmentioning

confidence: 99%

Association of Multidimensional Poverty With Dementia in Adults Aged 50 Years or Older in South Africa

et al. 2022

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“…1,2 Early diagnosis and intervention can effectively delay or prevent vascular cognitive impairment from developing into vascular dementia. 3,4 and-if so-whether distinct cognitive domains are affected more preferentially by CMB.\nMETHODS: In a prospective cohort study, cognitive performance was examined in 33 stroke patients showing ≥ 1 CMB on MRI. Matched for age, gender, clinical and radiological characteristics, 33 stroke survivors without CMB served as a control group.…”

Section: Introductionmentioning

confidence: 99%

“… 1 , 2 Early diagnosis and intervention can effectively delay or prevent vascular cognitive impairment from developing into vascular dementia. 3 , 4 Vascular dementia pathogenesis involves oxidative stress responses, which can be detected by measuring serum hemoglobin (Hb) levels. 5 Moreover, adiponectin (APN) has been recently found to improve vascular dementia in patients with atherosclerosis, glucose metabolism disorder, and hypertension.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of serum adiponectin and hemoglobin levels for vascular cognitive impairment in ischemic stroke patients

Li¹,

Zhu²,

Meng³

et al. 2022

Pak J Med Sci

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Objectives: To investigate the potential predictive value of serum adiponectin (APN) and hemoglobin (Hb) levels for the occurrence of vascular cognitive impairment in ischemic stroke patients. Methods: Eighty ischemic stroke patients, admitted to our hospital between June 2019 and November 2020, were retrospectively divided into no cognitive impairment (NCI) group (n=43) and cognitive impairment (CI) group (n=37) based on Montreal Cognitive Assessment (MoCA) scale scoring at three months follow-up. ELISA was used to assess serum Hb and APN levels and receiver operating characteristic (ROC) curves were created to evaluate correlation. Results: Serum APN and Hb levels were lower in the vascular cognitive impairment group compared to non-impaired counterparts. Pearson correlation analysis showed that both APN and Hb levels were positively correlated with MoCA scores. Area under curve analysis indicated predictive value for serum APN and Hb for predicting cognitive impairment in ischemic stroke patients. Conclusion: Serum APN and Hb levels in ischemic stroke patients have value for predicting vascular cognitive impairment and may be suitable for helping dictate treatment planning. doi: https://doi.org/10.12669/pjms.38.3.5204 How to cite this:Li Z, Zhu M, Meng C, Lin H, Huang L. Predictive value of serum adiponectin and hemoglobin levels for vascular cognitive impairment in ischemic stroke patients. Pak J Med Sci. 2022;38(3):705-710. doi: https://doi.org/10.12669/pjms.38.3.5204 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…Age is one of the most significant risk factors for pathological decline associated with dementia, in adults over 65 years old. Both brain and subtle neuropsychological changes may occur several years prior to the clinical manifestation of dementia (Sperling et al, 2011 ; Tondelli et al, 2012 ; Seetlani et al, 2016 ). Changes in brain structure, such as volume reductions, could occur prior to the onset of cognitive symptoms.…”

Section: Introductionmentioning

confidence: 99%

Regional Brain Volume, Brain Reserve and MMSE Performance in Healthy Aging From the NEUROAGE Cohort: Contributions of Sex, Education, and Depression Symptoms

Pettemeridou

Kallousia

Constantinidou

2021

Front. Aging Neurosci.

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Objective: The aim of this study was twofold. First, to investigate the relationship between age, gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) volumes, brain reserve (BR), and specific regions of interest (ROIs) with global cognitive function in healthy older adults participating in a longitudinal study on aging in the island country of Cyprus. Second, to assess the contribution of important demographic and psychosocial factors on brain volume. Specifically, the effects of sex and years of education and the association between depression symptoms on brain volume were also explored in this Mediterranean cohort.Methods: Eighty-seven healthy older adults (males = 37, females = 50) scoring ≥24 on the Mini-Mental State Examination (MMSE) were included, with a mean age of 72.75 years and a mean educational level of 10.48 years. The Geriatric Depression Scale was used to assess depression. T1-weighted magnetic resonance images were used to calculate global and regional volumes.Results: Age was negatively correlated with GM, WM, BR, MMSE scores, and ROIs, including the hippocampus, amygdala, entorhinal cortex, prefrontal cortex, anterior cingulate gyrus, and positively with CSF. Higher MMSE scores positively correlated with GM volume. Women exhibited greater levels of depression than men. Depression was also negatively correlated with GM volume and MMSE scores. Men had greater ventricular size than women and participants with higher education had greater ventricular expansion than those with fewer years in education.Conclusions: The reported structural changes provide evidence on the overlap between age-related brain changes and healthy cognitive aging and suggest that these age changes affect certain regions. Furthermore, sex, depressive symptomatology, and education are significant predictors of the aging brain. Brain reserve and higher education accommodate these changes and works against the development of clinical symptoms.

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Alzheimer and vascular dementia in the elderly patients

Cited by 14 publications

References 21 publications

Association of Multidimensional Poverty With Dementia in Adults Aged 50 Years or Older in South Africa

Association of Multidimensional Poverty With Dementia in Adults Aged 50 Years or Older in South Africa

Predictive value of serum adiponectin and hemoglobin levels for vascular cognitive impairment in ischemic stroke patients

Regional Brain Volume, Brain Reserve and MMSE Performance in Healthy Aging From the NEUROAGE Cohort: Contributions of Sex, Education, and Depression Symptoms

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