Alveolar soft part sarcoma of the endometrium with expression of CD10 and hormone receptors

Kasashima, Satomi; Minato, Hiroshi; Kobayashi, Masako; Ueda, Yoshimichi; Oda, Yoshio; Hashimoto, Shigeru; Inoue, Masakí

doi:10.1111/j.1600-0463.2007.apm_635.x

Cited by 22 publications

(5 citation statements)

References 13 publications

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“…While RCCs are usually immunopositive for CD10, EMA, vimentin, and variably for pan‐cytokeratin, ASPS typically does not react with these markers. Aberrant CD10 immunopositivity, as in our case, has been observed previously only in a single case of a uterine ASPS, where the authors hypothesized a possible link to endometrial stromal cells . We did not find any other CD10 immunopositive ASPS in our recent archival tissue.…”

Section: Discussionmentioning

confidence: 99%

Metastatic alveolar soft part sarcoma of the lung: Metastatic alveolar soft part sarcoma of the lung‐a morphologic pitfall on cytology and aberrant CD10 expression on histology

Nambirajan

Jain

Malik

et al. 2015

Diagnostic Cytopathology

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Alveolar soft part sarcoma (ASPS) is a rare aggressive soft tissue sarcoma of young adults, typically arising in the deep soft tissue of lower extremities. Although cytomorphology is characteristic enough for an accurate diagnosis in typical clinical scenarios, problems arise when it occurs in older patients, atypical sites, or in primary evaluation at metastatic sites. A 48-year-old smoker presented with breathlessness and headache for 2 months. Imaging showed a heterogeneous enhancing lesion of 6 cm × 6 cm in right middle lobe of lung, smaller miliary nodules in bilateral lungs, multiple bilateral cerebral lesions, and a mass of 3 cm × 3 cm in the left thigh. Primary lung carcinoma with brain and thigh metastases was the clinical diagnosis. Fine-needle aspiration smears of the lung lesion showed cohesive fragments of large cells with a prominent traversing branching capillary network and discohesion at periphery resulting in a pseudo-papillary appearance. Tumor cells had fine granular to vacuolated cytoplasm, frayed borders, and prominent nucleoli. Trucut biopsy from the same showed a tumor arranged in nests composed of large polygonal cells, immunopositive for CD10. Possibility of metastatic renal cell carcinoma (RCC) was offered. Abdominal imaging was, however, normal. Core biopsy from thigh showed a similar tumor, immunonegative for epithelial markers, with cytoplasmic periodic-acid-schiff positive rhomboid crystals, clinching the final diagnosis of ASPS with lung and brain metastases. There is considerable morphological and immunohistochemical overlap between ASPS and RCC. Bare nuclei on air dried smears, binucleation, metachromatic basement membrane material are subtle pointers toward ASPS.

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Section: Discussionmentioning

confidence: 99%

Metastatic alveolar soft part sarcoma of the lung: Metastatic alveolar soft part sarcoma of the lung‐a morphologic pitfall on cytology and aberrant CD10 expression on histology

Nambirajan

Jain

Malik

et al. 2015

Diagnostic Cytopathology

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“…Despite the name, clear cell sarcoma more commonly has eosinophilic cytoplasm. 176,177 CD10 expression has been reported in alveolar soft part sarcoma, 178 but other renal lineage markers have not been well studied. Immunohistochemically, clear cell sarcoma has a melanocytic phenotype with expression of S-100 protein, HMB-45, melanA, and other markers.…”

Section: Metastatic Clear Cell Renal Cell Carcinoma Versus Soft Tissumentioning

confidence: 99%

The Use of Immunohistochemistry in the Diagnosis of Metastatic Clear Cell Renal Cell Carcinoma

Sangoi

Karamchandani

Kim

et al. 2010

Advances in Anatomic Pathology

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The diagnosis of metastatic clear cell renal cell carcinoma may be difficult in some cases, particularly in the small image-guided biopsies that are becoming more common. As targeted therapies for renal cell carcinoma are now standard treatment, the recognition and diagnosis of renal cell carcinoma has become even more critical. Many adjunctive immunohistochemical markers of renal epithelial lineage such as CD10 and RCCma have been proposed as aids in the diagnosis of metastatic renal cell carcinoma, but low specificities often limit their utility. More recently described markers (PAX-2, PAX-8, human kidney injury molecule-1, hepatocyte nuclear factor-1-β, and carbonic anhydrase-IX) offer the potential for greater sensitivity and specificity in this diagnostic setting; however, knowledge of their expected staining in other neoplasms and tissues is critical for appropriate use. In this review, we discuss the most widely used immunohistochemical markers of renal lineage with an emphasis on their sensitivity and specificity for metastatic clear cell renal cell carcinoma. Subsequently, we present a variety of organ-specific differential diagnostic scenarios in which metastatic clear cell renal cell carcinoma might be considered and we propose immunopanels for use in each situation.

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“…This was described in a 57-yr-old female as multiple nodules in the vagina 5. Since then, several cases have been described in the literature, mostly as case reports and small series 6–10. A recent study described the largest series of these tumors involving the female genital tract.…”

Section: Discussionmentioning

confidence: 99%

Alveolar Soft Part Sarcoma of Uterine Corpus in a Young Female: A Case Report With Review of Literature

Vishwajeet

Elhence²,

Singh³

et al. 2020

International Journal of Gynecological Pathology

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Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma, often occurs in adolescents and young adults with a particular predilection for the deep soft tissue of extremities. Occurrence of ASPS in the female genital tract is very uncommon and poses a significant diagnostic challenge. A case of ASPS of the uterine corpus is described in a young unmarried female, who presented to the out-patient clinic of our Institute with complaints of abnormal uterine bleeding for the past 9 mo. She was being treated with oral contraceptive pills, progesterone and tranexamic acid. Following radiological imaging and hysteroscopy, a therapeutic curettage of the lesion was done. The histopathologic features raised a differential diagnosis of a myriad of morphologic mimickers. The diagnosis was clinched by exclusion of mimickers by relevant immunohistochemical markers and strong nuclear expression of TFE3 on immunohistochemistry. The patient is on regular follow-up with oral contraceptives and antifibrinolytic medication. Despite being infrequent at this location, ASPS should be kept in differential diagnosis in young females presenting with abnormal uterine bleeding.

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Alveolar soft part sarcoma of the endometrium with expression of CD10 and hormone receptors

Cited by 22 publications

References 13 publications

Metastatic alveolar soft part sarcoma of the lung: Metastatic alveolar soft part sarcoma of the lung‐a morphologic pitfall on cytology and aberrant CD10 expression on histology

Metastatic alveolar soft part sarcoma of the lung: Metastatic alveolar soft part sarcoma of the lung‐a morphologic pitfall on cytology and aberrant CD10 expression on histology

The Use of Immunohistochemistry in the Diagnosis of Metastatic Clear Cell Renal Cell Carcinoma

Alveolar Soft Part Sarcoma of Uterine Corpus in a Young Female: A Case Report With Review of Literature

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